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Erythrocin Stearate
Erythrocin Stearate is a formulation of erythromycin, a macrolide antibiotic used to treat a wide variety of bacterial infections. It is commonly prescribed for conditions like respiratory infections, skin infections, ear infections, and certain sexually transmitted infections (STIs). Erythrocin Stearate works by inhibiting bacterial growth and is often prescribed as an alternative to penicillin for individuals allergic to beta-lactam antibiotics.
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Frequently Asked Questions
Can I take Erythrocin Stearate with food?
It is best taken on an empty stomach, but if it causes stomach upset, you can take it with food.
How long does it take for Erythrocin Stearate to work?
You should start feeling better within a few days of starting Erythrocin Stearate. However, complete the full course of treatment to ensure the infection is fully resolved.
What should I do if I miss a dose?
Take the missed dose as soon as you remember. If it’s close to the time of the next dose, skip the missed dose and continue your regular schedule. Do not double the dose to catch up.
Can I take Erythrocin Stearate if I am pregnant?
Erythromycin is generally considered safe during pregnancy, but you should consult your healthcare provider to discuss the potential risks and benefits.
Is Erythrocin Stearate safe for children?
Yes, Erythrocin Stearate is commonly used to treat bacterial infections in children. The dosage is based on the child's weight and the type of infection being treated. Always follow your healthcare provider’s dosing instructions.
Comprehensive Drug Guide
How Does Erythrocin Stearate Work?
Erythromycin works by binding to the 50S ribosomal subunit of bacterial cells, inhibiting protein synthesis. This action prevents bacterial replication and allows the body to eliminate the infection. Erythrocin Stearate is considered bacteriostatic, meaning it inhibits the growth of bacteria rather than killing them directly.
What is Erythrocin Stearate Used For?
Common Dosages
Dosage depends on the type and severity of the infection:
- Adults: 250 mg every 6 hours or 500 mg every 12 hours for mild to moderate infections. For severe infections, the dose may be increased.
- Children: Dosage is typically based on body weight, with 30-50 mg/kg per day divided into multiple doses.
Typical Dosing
- Adults: The usual dose is 250 mg every 6 hours, or 500 mg every 12 hours, depending on the severity of the infection.
- Children: 30-50 mg/kg/day divided into 4 doses.
Typical Dosing
FDA Approved Indications
- Respiratory tract infections (e.g., bronchitis, pneumonia)
- Skin and soft tissue infections
- Ear infections (e.g., otitis media)
- Strep throat
- Pertussis (whooping cough)
- Sexually transmitted infections (e.g., chlamydia)
- Diphtheria
Who Shouldn't Take Erythrocin Stearate?
- Known hypersensitivity to erythromycin or other macrolide antibiotics.
- Severe liver disease or a history of liver problems caused by erythromycin.
- Myasthenia gravis (may exacerbate muscle weakness).
Advice From The Pharmacist
- Erythrocin Stearate should be taken on an empty stomach—either 30 minutes before or 2 hours after meals—for better absorption. If stomach upset occurs, it can be taken with food.
- Swallow the tablets whole; do not crush or chew them.
- Complete the full course of antibiotics even if you feel better, as stopping the medication early may cause the infection to return.
- Store tablets at room temperature and away from moisture and light.
Side Effects of Erythrocin Stearate
Common Side Effects
- Nausea
- Diarrhea
- Stomach pain or cramps
- Vomiting
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, hives, difficulty breathing)
- Liver damage (jaundice, dark urine, upper abdominal pain)
- Hearing loss (with high doses or prolonged use)
- QT prolongation (irregular heart rhythm)
Risks and Warnings of Erythrocin Stearate
- QT Prolongation: Erythromycin can prolong the QT interval, potentially leading to an irregular heartbeat or life-threatening arrhythmias, especially in patients with pre-existing heart conditions.
- Liver Toxicity: Erythromycin has been associated with liver damage, particularly in patients with pre-existing liver disease. Discontinue the drug and seek medical attention if signs of liver dysfunction, such as jaundice or dark urine, appear.
- Clostridium difficile-associated diarrhea: Prolonged use of antibiotics like erythromycin may lead to severe diarrhea caused by C. difficile overgrowth.
Interactions with Erythrocin Stearate
Common Drug Interactions
- Warfarin: Erythromycin may increase the anticoagulant effects of warfarin, raising the risk of bleeding.
- Statins: When taken with certain statins (like atorvastatin or simvastatin), erythromycin may increase the risk of rhabdomyolysis (muscle breakdown).
- Theophylline: Erythromycin can increase the levels of theophylline, leading to an increased risk of nausea, vomiting, and other side effects.
- QT-prolonging drugs: Combining erythromycin with medications that prolong the QT interval (e.g., amiodarone or quinidine) may increase the risk of serious heart arrhythmias.
Alternatives to Erythrocin Stearate
- Azithromycin: Another macrolide antibiotic that can be taken less frequently due to its longer half-life.
- Clindamycin: An alternative antibiotic for those who cannot tolerate macrolides, used to treat similar bacterial infections.
- Amoxicillin: A penicillin-class antibiotic used for respiratory and skin infections in patients who are not allergic to penicillin.
