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EryPed 400
EryPed 400 is a formulation of erythromycin ethylsuccinate, a macrolide antibiotic used to treat a variety of bacterial infections. It is effective against a wide range of gram-positive and gram-negative bacteria. EryPed 400 is commonly prescribed for respiratory infections, skin infections, ear infections, and certain sexually transmitted infections (STIs). It is often used as an alternative for patients allergic to penicillin.
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Frequently Asked Questions
Can I take EryPed 400 with food?
While EryPed 400 is better absorbed on an empty stomach, it can be taken with food if it causes stomach upset.
How long does it take for EryPed 400 to work?
You should start feeling better within a few days of starting EryPed 400. However, continue taking the medication for the full prescribed duration to avoid a return of the infection.
What should I do if I miss a dose of EryPed 400?
If you miss a dose, take it as soon as you remember. If it is close to the time of your next dose, skip the missed dose and continue with your regular schedule. Do not double up doses.
Can I take EryPed 400 if I am pregnant?
Erythromycin is generally considered safe during pregnancy. However, consult your healthcare provider to discuss the risks and benefits in your specific case.
Is EryPed 400 safe for children?
Yes, EryPed 400 is commonly used in children to treat bacterial infections. The dosage will be adjusted based on the child's weight and the infection type. Always follow the pediatrician’s dosing instructions.
Comprehensive Drug Guide
How Does EryPed 400 Work?
Erythromycin ethylsuccinate works by binding to the 50S ribosomal subunit of bacterial cells, inhibiting bacterial protein synthesis. This action prevents the bacteria from growing and replicating, allowing the body’s immune system to clear the infection.
Common Dosages
- For children: The usual dose is 30 to 50 mg/kg per day, divided into 4 doses. The specific dose is based on the child’s weight and the severity of the infection.
- For adults: The usual dose is 400 mg every 6 hours, depending on the severity of the infection.
Typical Dosing
- Children: Typically 30-50 mg/kg/day, divided into 4 doses daily. The healthcare provider will determine the exact dose based on the child’s weight.
- Adults: Usually 400 mg every 6 hours for mild to moderate infections.
Typical Dosing
FDA Approved Indications
- Respiratory tract infections (e.g., bronchitis, pneumonia)
- Skin and soft tissue infections
- Ear infections (e.g., otitis media)
- Strep throat
- Pertussis (whooping cough)
- Sexually transmitted infections (e.g., chlamydia)
Who Shouldn't Take EryPed 400?
- Known hypersensitivity to erythromycin or any macrolide antibiotics.
- Liver dysfunction or a history of liver problems caused by erythromycin.
- Myasthenia gravis (can worsen muscle weakness).
Advice From The Pharmacist
- Shake the oral suspension well before each dose to ensure proper mixing.
- EryPed 400 should be taken on an empty stomach, either 30 minutes before or 2 hours after meals, to enhance absorption. If stomach upset occurs, it can be taken with food.
- Complete the full course of antibiotics as prescribed, even if symptoms improve before finishing the medication.
- Store the suspension in the refrigerator, and discard any unused portion after 10 days.
Side Effects of EryPed 400
Common Side Effects
- Nausea
- Diarrhea
- Stomach pain or cramping
- Vomiting
Uncommon/Severe Side Effects
- Severe allergic reactions (hives, difficulty breathing, swelling)
- Liver dysfunction (jaundice, dark urine, abdominal pain)
- QT prolongation (irregular heart rhythm)
- Clostridium difficile-associated diarrhea (persistent diarrhea)
Risks and Warnings of EryPed 400
- QT Prolongation: Erythromycin can prolong the QT interval, which may lead to an irregular heartbeat or even life-threatening arrhythmias, especially in patients with heart conditions or taking other QT-prolonging medications.
- Liver Toxicity: Erythromycin has been associated with liver dysfunction, particularly in patients with pre-existing liver disease. Discontinue use if signs of liver problems, such as jaundice or dark urine, appear.
- Clostridium difficile infection: Antibiotic use can disrupt the normal bacterial flora of the gut, potentially leading to an overgrowth of C. difficile, causing severe diarrhea.
Interactions with EryPed 400
Common Drug Interactions
- Warfarin: Erythromycin may increase the anticoagulant effects of warfarin, increasing the risk of bleeding.
- Statins: When taken with certain statins (like atorvastatin), erythromycin can increase the risk of rhabdomyolysis (muscle damage).
- Theophylline: Erythromycin can increase the levels of theophylline, leading to an increased risk of side effects such as nausea, vomiting, and restlessness.
- QT-prolonging drugs: Erythromycin should not be used with medications that prolong the QT interval, such as amiodarone or quinidine, due to the increased risk of cardiac arrhythmias.
Alternatives to EryPed 400
- Azithromycin: A macrolide antibiotic with a longer half-life and less frequent dosing compared to erythromycin.
- Clindamycin: Another antibiotic used for treating similar infections, especially in patients who cannot tolerate macrolides.
- Amoxicillin: A broad-spectrum antibiotic often used for respiratory and skin infections in patients who are not allergic to penicillin.
