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Ergoloid Mesylates
Ergoloid Mesylates is a combination of dihydroergocornine, dihydroergocristine, and dihydroergocryptine, which are alkaloids derived from ergot. This medication is used primarily for treating cognitive decline and symptoms associated with age-related mental disorders, including confusion, mood changes, and reduced motivation. While its exact mechanism in improving mental function is not fully understood, it is believed to increase blood flow to the brain and improve oxygen use in brain tissues.
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Frequently Asked Questions
How long does it take for Ergoloid Mesylates to show effects?
It may take several weeks before you notice significant improvements in cognitive function or mood. Be patient and continue taking the medication as prescribed.
Can Ergoloid Mesylates prevent dementia?
No, Ergoloid Mesylates is not a cure or preventive treatment for dementia. It is used to treat symptoms of cognitive decline associated with aging, but it is not effective for progressive neurodegenerative diseases like Alzheimer’s.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it’s close to the time of your next dose, skip the missed dose and continue your regular schedule. Do not double up doses.
Is it safe to take Ergoloid Mesylates if I have high blood pressure?
Caution is advised if you have hypertension. Ergoloid mesylates can increase blood pressure, so you should discuss this with your healthcare provider before starting the medication.
Can Ergoloid Mesylates be used long-term?
Yes, this medication can be used long-term, but its effectiveness should be periodically evaluated by your healthcare provider. If there are no improvements in cognitive function after several months, the treatment plan may need to be adjusted.
Comprehensive Drug Guide
How Does Ergoloid Mesylates Work?
Although the exact mechanism is unclear, ergoloid mesylates are believed to work by increasing cerebral blood flow and enhancing metabolic efficiency in brain tissue, leading to improved cognitive function. The drug is thought to influence various neurotransmitter systems, including dopamine and serotonin, which may explain its effect on mood and cognition.
Common Dosages
The typical dosage for ergoloid mesylates is:
- 1 mg sublingual tablet, taken three times daily.
- 1 mg oral tablet, taken two to three times daily depending on the severity of symptoms.
Typical Dosing
- Adults: The usual dose is 1 mg sublingually or orally two or three times per day. The dosage may be adjusted depending on the patient’s response to the medication and the severity of symptoms.
Typical Dosing
FDA Approved Indications
Symptomatic treatment of cognitive decline related to aging, particularly in patients with chronic cerebrovascular insufficiency or other forms of cognitive impairment not caused by progressive degenerative diseases such as Alzheimer’s.
Who Shouldn't Take Ergoloid Mesylates?
- Known hypersensitivity to ergot derivatives
- Severe peripheral vascular disease
- Hypertension (uncontrolled)
- Pregnancy (due to the risk of uterine contractions)
Advice From The Pharmacist
- Ergoloid mesylates can be taken with or without food, but if taken sublingually, allow the tablet to dissolve completely under the tongue for faster absorption.
- Do not crush or chew the tablet. If taking the sublingual form, avoid swallowing until the tablet is fully dissolved.
- It may take several weeks before you notice significant improvements in cognitive function or mood.
- This medication is often prescribed as part of a comprehensive treatment plan, including lifestyle modifications and cognitive therapies.
Side Effects of Ergoloid Mesylates
Common Side Effects
- Nausea
- Dizziness
- Mild headache
- Stomach upset
Uncommon/Severe Side Effects
- Peripheral vasoconstriction (narrowing of blood vessels)
- Bradycardia (slow heart rate)
- Hypertension (high blood pressure)
Risks and Warnings of Ergoloid Mesylates
- Peripheral Vascular Disease: Because ergoloid mesylates are derived from ergot, they may cause vasoconstriction and worsen symptoms in patients with pre-existing peripheral vascular disease.
- Hypertension: This medication can cause an increase in blood pressure, particularly in individuals with uncontrolled hypertension.
- Drug Interactions: Caution should be taken if you are taking other vasoconstrictors, such as beta-blockers or triptans, due to the risk of severe hypertension or circulatory issues.
Interactions with Ergoloid Mesylates
Common Drug Interactions
- Beta-blockers: May enhance the vasoconstrictive effects of ergoloid mesylates, leading to an increased risk of hypertension and bradycardia.
- Triptans: Used for migraines, they can increase the risk of vasoconstriction and circulatory complications.
- Anticoagulants: May increase the risk of bleeding when combined with ergoloid mesylates due to its possible effects on blood flow.
- Serotonergic drugs: Combining with drugs that influence serotonin (such as SSRIs) may lead to an increased risk of side effects related to serotonin activity.
Alternatives to Ergoloid Mesylates
- Donepezil (Aricept): Used for cognitive decline related to Alzheimer’s and other forms of dementia.
- Memantine (Namenda): A cognitive enhancer used for moderate to severe Alzheimer’s disease.
- Ginkgo biloba: An herbal supplement that may improve cognitive function and memory, although its efficacy is not proven to be as significant as prescription medications.
- Piracetam: A nootropic drug used in some countries to improve cognitive function and memory, though its use is controversial and not FDA-approved in the United States.
