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Enpresse-28
Enpresse-28 is a combination oral contraceptive pill (birth control) containing the hormones levonorgestrel (a progestin) and ethinyl estradiol (an estrogen). It is used to prevent pregnancy by inhibiting ovulation (the release of an egg from an ovary), thickening cervical mucus to prevent sperm from reaching the egg, and thinning the uterine lining to make it less suitable for a fertilized egg to implant. Enpresse-28 follows a triphasic dosing schedule, where hormone levels change throughout the 28-day cycle to mimic the body’s natural menstrual cycle.
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Frequently Asked Questions
What should I do if I miss a pill?
If you miss one pill, take it as soon as you remember, even if it means taking two pills in one day. If you miss two or more pills, take the most recent missed pill and use backup contraception (like condoms) for the next 7 days.
Can I skip my period while on Enpresse-28?
While it is not specifically designed for skipping periods, you can skip your period by skipping the placebo pills and starting a new pack of active pills immediately. Consult your healthcare provider before doing so.
How effective is Enpresse-28 at preventing pregnancy?
When taken correctly, Enpresse-28 is over 99% effective at preventing pregnancy. However, with typical use (missed pills, etc.), the effectiveness is around 91%.
Can I take Enpresse-28 if I’m breastfeeding?
Enpresse-28 is not recommended for breastfeeding women as it may reduce milk supply. Progestin-only pills (also called the "mini-pill") are a safer option for breastfeeding mothers.
When will I be protected from pregnancy after starting Enpresse-28?
If you start taking Enpresse-28 on the first day of your period, you are protected from pregnancy immediately. If you start on any other day, use backup contraception (like condoms) for the first 7 days of taking the pill.
Comprehensive Drug Guide
How Does Enpresse-28 Work?
Enpresse-28 works primarily by preventing ovulation (the release of an egg from the ovary). It also thickens the cervical mucus, making it difficult for sperm to enter the uterus, and alters the uterine lining, making it less likely for a fertilized egg to implant. These combined effects effectively prevent pregnancy.
Common Dosages
- Levonorgestrel (progestin) and Ethinyl estradiol (estrogen) in a triphasic dose:
- Days 1-6: 0.05 mg levonorgestrel / 0.03 mg ethinyl estradiol
- Days 7-11: 0.075 mg levonorgestrel / 0.04 mg ethinyl estradiol
- Days 12-21: 0.125 mg levonorgestrel / 0.03 mg ethinyl estradiol
- Placebo (inactive) pills: Days 22-28
Typical Dosing
- One tablet should be taken once daily at the same time each day. Start with the first active pill (Day 1) and continue through Day 21. During Days 22-28, take the placebo pills to maintain the habit of daily dosing. A new pack should be started immediately after finishing the 28-day pack, with no gap between packs.
Typical Dosing
Who Shouldn't Take Enpresse-28?
- History of thrombotic disorders (e.g., deep vein thrombosis, pulmonary embolism)
- History of stroke or heart attack
- Uncontrolled high blood pressure
- Severe liver disease
- Breast cancer or estrogen-dependent cancers
- Known hypersensitivity to levonorgestrel, ethinyl estradiol, or any components of the formulation
- Pregnancy
Advice From The Pharmacist
- Take Enpresse-28 at the same time every day to maintain consistent hormone levels and ensure maximum effectiveness.
- If you miss a dose, take it as soon as you remember. If you miss two or more doses, follow the instructions provided in the patient information leaflet, as backup contraception (like condoms) may be needed.
- If you experience nausea, taking the pill with food or at bedtime may help.
- Remember that Enpresse-28 does not protect against sexually transmitted infections (STIs). Consider using condoms for protection against STIs.
- Inform your doctor if you experience any unusual symptoms, such as severe headaches, vision changes, or leg pain, as these may be signs of serious side effects.
Side Effects of Enpresse-28
Common Side Effects
- Nausea
- Breast tenderness
- Headache
- Weight changes
- Mood swings or depression
- Spotting or breakthrough bleeding, especially in the first few months
Uncommon/Severe Side Effects
- Blood clots (e.g., deep vein thrombosis, pulmonary embolism)
- Stroke or heart attack
- High blood pressure
- Liver problems (e.g., liver tumors)
- Severe allergic reactions (swelling, difficulty breathing)
Risks and Warnings of Enpresse-28
- Blood Clots: Combination oral contraceptives, including Enpresse-28, increase the risk of blood clots, especially in women who smoke, are over 35, or have other risk factors for cardiovascular disease.
- Smoking: Women who smoke while using Enpresse-28 have a significantly increased risk of serious cardiovascular side effects like stroke, heart attack, and blood clots.
- Breast Cancer Risk: Enpresse-28 may slightly increase the risk of breast cancer, especially in women with a family history of the disease.
- Liver Problems: Rarely, combination oral contraceptives can cause liver damage or benign liver tumors.
Interactions with Enpresse-28
Common Drug Interactions
- Antibiotics (e.g., rifampin): Can reduce the effectiveness of Enpresse-28 by lowering hormone levels.
- Anticonvulsants (e.g., carbamazepine, phenytoin): May decrease the effectiveness of oral contraceptives.
- St. John’s Wort: May decrease the effectiveness of Enpresse-28 and increase the risk of breakthrough bleeding.
- HIV medications: Certain drugs used to treat HIV may reduce the effectiveness of Enpresse-28.
Alternatives to Enpresse-28
- Ortho Tri-Cyclen: Another triphasic oral contraceptive with different dosing and hormone levels.
- Seasonale: An extended-cycle birth control pill that allows for fewer periods (once every three months).
- NuvaRing: A vaginal ring that delivers a combination of hormones and is inserted once a month.
- Nexplanon: A long-acting, reversible contraceptive implant that provides protection for up to 3 years.
