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Eliquis DVT/PE Starter Pack
Eliquis (apixaban) is an anticoagulant (blood thinner) used to treat and prevent deep vein thrombosis (DVT) and pulmonary embolism (PE). DVT is a condition where blood clots form in deep veins, often in the legs, while PE occurs when a clot travels to the lungs, potentially causing life-threatening complications. Eliquis works by inhibiting Factor Xa, a key protein in the blood clotting process, reducing the likelihood of clots forming or growing larger. The Eliquis DVT/PE Starter Pack is designed to provide an initial dosing regimen for patients starting treatment for DVT and PE.
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Frequently Asked Questions
How long will I need to take Eliquis for DVT/PE treatment?
Typically, Eliquis is taken for at least 3 to 6 months after a DVT or PE event, but the duration may vary depending on your risk factors and healthcare provider’s recommendation.
What should I do if I miss a dose of Eliquis?
If you miss a dose, take it as soon as you remember. If it’s close to the time of your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take two doses at once.
Can I drink alcohol while taking Eliquis?
Moderate alcohol consumption is generally considered safe, but alcohol can increase the risk of bleeding. It’s best to discuss alcohol intake with your healthcare provider.
Will I need regular blood tests while taking Eliquis?
Unlike warfarin, Eliquis does not require routine blood monitoring. However, you may still need regular check-ups with your healthcare provider to monitor for any potential side effects.
Can I stop taking Eliquis if my symptoms improve?
You should not stop taking Eliquis without consulting your healthcare provider, even if your symptoms improve. Stopping the medication prematurely may increase the risk of a blood clot.
Comprehensive Drug Guide
How Does Eliquis DVT/PE Starter Pack Work?
Apixaban, the active ingredient in Eliquis, works by selectively inhibiting Factor Xa, an essential enzyme in the coagulation cascade that leads to blood clot formation. By blocking Factor Xa, Eliquis reduces the formation of fibrin, which is necessary for clot formation, preventing the development or growth of dangerous clots in the veins or lungs.
Common Dosages
The Eliquis DVT/PE Starter Pack contains:
- 10 mg tablets: Take twice daily for the first 7 days.
- 5 mg tablets: Take twice daily for maintenance treatment starting on Day 8.
Typical Dosing
- For the treatment of DVT/PE, the initial dose is 10 mg twice daily for the first 7 days.
- After the initial 7 days, the dose is reduced to 5 mg twice daily for maintenance.
- In some cases, after 6 months of treatment, your doctor may recommend a further dose reduction to 2.5 mg twice daily to reduce the risk of recurrent DVT/PE.
Typical Dosing
FDA Approved Indications
- Treatment of deep vein thrombosis (DVT)
- Treatment of pulmonary embolism (PE)
- Reduction in the risk of recurrent DVT and PE following initial therapy
Who Shouldn't Take Eliquis DVT/PE Starter Pack?
- Active bleeding
- Severe liver disease
- Known hypersensitivity to apixaban or any component of the formulation
- Those with conditions associated with a high risk of bleeding
Advice From The Pharmacist
- Take Eliquis exactly as prescribed. It can be taken with or without food.
- Do not stop taking Eliquis without consulting your healthcare provider, as stopping abruptly may increase the risk of a blood clot or stroke.
- If you miss a dose, take it as soon as you remember. Do not double up on the next dose.
- Inform all healthcare providers, including dentists, that you are taking Eliquis before undergoing any procedures, as special precautions may be needed to reduce bleeding risks.
- Avoid activities that may increase your risk of injury or bleeding, as Eliquis increases the likelihood of bleeding even from minor cuts or injuries.
Side Effects of Eliquis DVT/PE Starter Pack
Common Side Effects
- Easy bruising
- Minor bleeding (nosebleeds, bleeding gums)
- Nausea
- Anemia (low red blood cell count)
Uncommon/Severe Side Effects
- Severe bleeding (unusual bleeding from gums, nose, or rectum)
- Hemorrhage (bleeding in the brain, gastrointestinal tract, or other areas)
- Allergic reactions (rash, itching, swelling, difficulty breathing)
- Spinal/epidural hematoma (may occur if receiving spinal anesthesia or puncture)
Risks and Warnings of Eliquis DVT/PE Starter Pack
- Bleeding Risk: As an anticoagulant, Eliquis increases the risk of bleeding, which can be serious or life-threatening. Patients should be monitored for signs of bleeding, such as unusual bruising, prolonged bleeding, or blood in the urine or stool.
- Spinal/Epidural Hematomas: Patients receiving spinal anesthesia or undergoing spinal puncture while on Eliquis are at risk for developing a hematoma, which can lead to paralysis. Careful monitoring is required in these cases.
- Discontinuation: Stopping Eliquis suddenly increases the risk of blood clots. Always consult your healthcare provider before stopping the medication.
Interactions with Eliquis DVT/PE Starter Pack
Common Drug Interactions
- Other Anticoagulants or Antiplatelet Drugs: Combining Eliquis with other blood thinners (e.g., warfarin, aspirin, clopidogrel) increases the risk of bleeding.
- CYP3A4 and P-gp Inhibitors: Drugs like ketoconazole, itraconazole, and clarithromycin can increase apixaban levels, increasing the risk of side effects.
- CYP3A4 Inducers: Drugs like rifampin, carbamazepine, and St. John’s Wort can reduce the effectiveness of Eliquis by lowering its levels in the blood.
Alternatives to Eliquis DVT/PE Starter Pack
- Xarelto (rivaroxaban): Another Factor Xa inhibitor used for the treatment and prevention of DVT and PE.
- Pradaxa (dabigatran): A direct thrombin inhibitor used for similar indications, such as prevention of stroke in patients with atrial fibrillation and treatment of DVT/PE.
- Warfarin (Coumadin): A traditional blood thinner used for DVT and PE prevention, though it requires regular blood monitoring and has more dietary restrictions.
- Enoxaparin (Lovenox): A low molecular weight heparin used for DVT prevention and treatment, often administered as an injection.
