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Dutoprol
Dutoprol is a combination medication containing metoprolol succinate (a beta-blocker) and hydrochlorothiazide (a thiazide diuretic) used to treat high blood pressure (hypertension). Metoprolol helps lower blood pressure by slowing the heart rate and reducing the workload on the heart, while hydrochlorothiazide works by helping the body get rid of excess salt and water, which reduces blood pressure. This combination is effective in managing blood pressure to reduce the risk of heart attack, stroke, and kidney problems.
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Frequently Asked Questions
Can I stop taking Dutoprol once my blood pressure is controlled?
No, Dutoprol is meant for long-term management of blood pressure. Stopping it suddenly can lead to serious complications, such as rebound hypertension or heart issues.
How long does it take for Dutoprol to start working?
Blood pressure may start to decrease within a few days, but it can take up to 2 weeks to see the full effect.
Can Dutoprol cause low potassium levels?
Yes, hydrochlorothiazide in Dutoprol can cause low potassium levels, which may require monitoring or potassium supplements.
Should I avoid certain foods or drinks while taking Dutoprol?
It's best to avoid excessive salt intake, as this can counteract the effects of Dutoprol. Also, limit alcohol consumption, as it may increase dizziness or lower blood pressure.
What should I do if I miss a dose of Dutoprol?
If you miss a dose, take it as soon as you remember unless it’s close to the time for your next dose. Do not double up on doses to make up for the missed one.
Comprehensive Drug Guide
How Does Dutoprol Work?
- Metoprolol blocks beta-1 adrenergic receptors in the heart, reducing heart rate, cardiac output, and blood pressure.
- Hydrochlorothiazide helps reduce blood pressure by increasing the excretion of salt and water from the kidneys, reducing fluid volume and pressure in the blood vessels.
Common Dosages
- 25 mg metoprolol succinate / 12.5 mg hydrochlorothiazide
- 50 mg metoprolol succinate / 12.5 mg hydrochlorothiazide
- 100 mg metoprolol succinate / 12.5 mg hydrochlorothiazide
Typical Dosing
- The typical starting dose of Dutoprol is one tablet daily, usually in the morning, with the dose adjusted based on blood pressure control. The maximum dose is 200 mg metoprolol / 25 mg hydrochlorothiazide per day.
Typical Dosing
FDA Approved Indications
- Hypertension (high blood pressure)
Who Shouldn't Take Dutoprol?
- Severe bradycardia (slow heart rate)
- Heart block greater than first degree
- Cardiogenic shock
- Known hypersensitivity to metoprolol, hydrochlorothiazide, or sulfonamide-derived drugs
- Severe liver or kidney impairment
Advice From The Pharmacist
- Take Dutoprol once daily with or without food, preferably in the morning.
- Do not stop taking Dutoprol suddenly, as this can lead to serious heart problems such as rebound hypertension or angina.
- Inform your healthcare provider if you experience dizziness, lightheadedness, or fainting, as these could be signs of low blood pressure.
- If you are taking other blood pressure medications or have any kidney or liver issues, consult your doctor before using Dutoprol.
Side Effects of Dutoprol
Common Side Effects
- Dizziness
- Fatigue
- Headache
- Increased urination (due to hydrochlorothiazide)
Uncommon/Severe Side Effects
- Bradycardia (slow heart rate)
- Electrolyte imbalances (low potassium or sodium)
- Severe hypotension
- Worsening of asthma or bronchospasm (for those with lung conditions)
Risks and Warnings of Dutoprol
- Heart Failure: While Dutoprol is used to treat heart conditions, it may worsen heart failure in some cases. Patients with heart failure should be closely monitored.
- Electrolyte Imbalance: Hydrochlorothiazide can cause imbalances in electrolytes, such as low potassium, which may require supplementation or monitoring.
- Renal Function: Thiazide diuretics may affect kidney function, particularly in individuals with existing kidney disease.
Interactions with Dutoprol
Common Drug Interactions
- Other antihypertensives: May enhance the blood pressure-lowering effect of Dutoprol, leading to low blood pressure.
- NSAIDs: These medications can reduce the effectiveness of Dutoprol and increase the risk of kidney damage.
- Insulin or oral antidiabetics: Metoprolol may mask signs of low blood sugar (hypoglycemia), requiring close monitoring in diabetic patients.
Alternatives to Dutoprol
- Lopressor HCT: A combination of metoprolol tartrate and hydrochlorothiazide used to treat high blood pressure.
- Atenolol-Chlorthalidone: A combination of atenolol (a beta-blocker) and chlorthalidone (a thiazide diuretic) for blood pressure control.
- Benicar HCT: A combination of olmesartan (an angiotensin receptor blocker) and hydrochlorothiazide.
