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Dutasteride
Dutasteride is a 5-alpha-reductase inhibitor used to treat benign prostatic hyperplasia (BPH), a condition in which the prostate gland becomes enlarged, leading to urinary difficulties. By inhibiting the conversion of testosterone to dihydrotestosterone (DHT), Dutasteride helps reduce prostate size, relieve urinary symptoms, and improve overall urinary flow in men. It is often used in combination with other medications like alpha-blockers for enhanced treatment efficacy.
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Frequently Asked Questions
How long does it take for Dutasteride to work?
It may take 3 to 6 months of regular use to notice significant improvements in BPH symptoms such as urine flow and frequency.
Can Dutasteride be used to treat hair loss?
Dutasteride is sometimes used off-label to treat male pattern baldness, but it is not FDA-approved for this purpose. Consult your doctor for more information on its use for hair loss.
Is it safe for women to take Dutasteride?
No, Dutasteride is not approved for use in women, particularly those who are pregnant or may become pregnant, due to the risk of birth defects.
Can I take Dutasteride with other BPH medications?
Yes, Dutasteride is often prescribed alongside alpha-blockers like tamsulosin for enhanced symptom relief. Always follow your doctor’s instructions when combining medications.
What should I do if I miss a dose of Dutasteride?
If you miss a dose, take it as soon as you remember. If it’s close to the time of your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses.
Comprehensive Drug Guide
How Does Dutasteride Work?
Dutasteride works by inhibiting the enzyme 5-alpha-reductase, which is responsible for converting testosterone into dihydrotestosterone (DHT). DHT is a hormone that contributes to the enlargement of the prostate. By reducing DHT levels, Dutasteride shrinks the prostate and relieves urinary symptoms associated with BPH.
Common Dosages
- Capsules: 0.5 mg
Typical Dosing
- For BPH: The typical dose is 0.5 mg taken once daily. Treatment is often long-term, and it may take several months to notice significant symptom improvement.
Typical Dosing
FDA Approved Indications
- Benign prostatic hyperplasia (BPH) in men with an enlarged prostate
Who Shouldn't Take Dutasteride?
- Known hypersensitivity to Dutasteride or other 5-alpha-reductase inhibitors
- Women and children (as Dutasteride is not approved for use in these populations)
- Severe liver disease
Advice From The Pharmacist
- Take Dutasteride exactly as prescribed, usually once daily, and do not crush or chew the capsules.
- Women who are pregnant or may become pregnant should avoid handling Dutasteride capsules, as the medication can be absorbed through the skin and cause birth defects.
- It may take 3-6 months for Dutasteride to show significant improvement in BPH symptoms, so it’s important to continue taking the medication regularly.
- Regular prostate-specific antigen (PSA) tests are recommended to monitor prostate health, as Dutasteride can affect PSA levels.
Side Effects of Dutasteride
Common Side Effects
- Decreased libido
- Erectile dysfunction
- Ejaculation disorders
- Breast tenderness or enlargement
Uncommon/Severe Side Effects
- Allergic reactions (rash, swelling, difficulty breathing)
- High-grade prostate cancer (rare but possible)
Risks and Warnings of Dutasteride
- Prostate Cancer Risk: Dutasteride has been associated with an increased risk of developing high-grade prostate cancer. Regular monitoring through PSA testing is important while on this medication.
- Sexual Dysfunction: Dutasteride can cause sexual side effects such as reduced libido, erectile dysfunction, and ejaculation problems. These effects may persist after discontinuing the medication in some cases.
- Handling Precautions: Women of childbearing age should not handle broken or crushed Dutasteride capsules due to the risk of absorption and potential harm to a developing fetus.
Interactions with Dutasteride
Common Drug Interactions
- CYP3A4 inhibitors: Medications like ketoconazole and ritonavir may increase the blood levels of Dutasteride, potentially leading to an increased risk of side effects.
- Blood thinners: Dutasteride may interact with blood thinners like warfarin, requiring close monitoring of blood clotting times.
Alternatives to Dutasteride
- Finasteride (Proscar): Another 5-alpha-reductase inhibitor used to treat BPH with a similar mechanism of action.
- Tamsulosin (Flomax): An alpha-blocker that relaxes the muscles of the bladder and prostate, improving urine flow.
- Surgery: In severe cases of BPH, surgical options like transurethral resection of the prostate (TURP) may be considered.
