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Durlaza
Durlaza (aspirin extended-release capsules) is a nonsteroidal anti-inflammatory drug (NSAID) specifically formulated to reduce the risk of heart attack, stroke, and other cardiovascular events in patients with a history of cardiovascular disease. It works by inhibiting platelet aggregation, which helps prevent blood clots from forming. The extended-release formulation of Durlaza allows for a once-daily dosing regimen, providing consistent protection throughout the day and night.
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Frequently Asked Questions
How long does it take for Durlaza to start working?
Durlaza provides continuous platelet inhibition and protection from clot formation starting within hours of the first dose, with sustained effects due to its extended-release formulation.
Can I take Durlaza with food?
Yes, Durlaza can be taken with or without food. Taking it with food may help reduce gastrointestinal discomfort.
What should I do if I miss a dose of Durlaza?
If you miss a dose, take it as soon as you remember. If it is close to your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Can I take Durlaza with other NSAIDs like ibuprofen?
It is not recommended to take Durlaza with other NSAIDs, as this can increase the risk of gastrointestinal bleeding. Always consult your healthcare provider before taking any additional medications.
Is Durlaza safe for long-term use?
Yes, Durlaza is designed for long-term use to help prevent cardiovascular events in individuals at risk. Regular monitoring by your healthcare provider is important to ensure it remains safe and effective.
Comprehensive Drug Guide
How Does Durlaza Work?
Durlaza works by irreversibly inhibiting cyclooxygenase-1 (COX-1), an enzyme responsible for the production of thromboxane A2, a chemical that promotes platelet aggregation. By reducing thromboxane A2 levels, Durlaza decreases the ability of platelets to stick together, thus reducing the formation of blood clots and lowering the risk of heart attack and stroke.
Common Dosages
- Extended-release capsules: 162.5 mg
Typical Dosing
- For cardiovascular protection: The typical dose is 162.5 mg once daily, taken with or without food. The capsule should be swallowed whole, not crushed or chewed.
Typical Dosing
FDA Approved Indications
- Reducing the risk of myocardial infarction (heart attack) in patients with a history of cardiovascular disease.
- Reducing the risk of ischemic stroke and transient ischemic attacks (TIA) in patients with a history of stroke or TIA.
- Managing patients with peripheral arterial disease (PAD).
Who Shouldn't Take Durlaza?
- Aspirin allergy or NSAID sensitivity (e.g., history of asthma, rhinitis, or nasal polyps triggered by NSAIDs)
- Active gastrointestinal bleeding or peptic ulcer disease
- Severe kidney or liver disease
Advice From The Pharmacist
- Take Durlaza exactly as prescribed, once daily, and do not crush or chew the capsules to maintain the extended-release effect.
- Avoid taking Durlaza with other NSAIDs unless directed by your healthcare provider, as this can increase the risk of gastrointestinal bleeding.
- Report any signs of bleeding, such as black or tarry stools, or unusual bruising, to your healthcare provider.
- Durlaza may interact with other blood thinners like warfarin, so monitoring is necessary to ensure safety.
Side Effects of Durlaza
Common Side Effects
- Heartburn or indigestion
- Nausea
- Mild gastrointestinal discomfort
Uncommon/Severe Side Effects
- Gastrointestinal bleeding (black stools, vomiting blood)
- Allergic reactions (rash, swelling, difficulty breathing)
- Kidney dysfunction (reduced urine output, swelling in the legs or ankles)
Risks and Warnings of Durlaza
- Gastrointestinal Bleeding: Durlaza may increase the risk of bleeding, especially in the gastrointestinal tract. Patients with a history of ulcers or those taking blood thinners should be monitored closely.
- Reye’s Syndrome: Aspirin, including Durlaza, should not be given to children or teenagers with viral infections due to the risk of Reye’s syndrome, a rare but serious condition.
- Allergic Reactions: Individuals allergic to aspirin or other NSAIDs may experience serious allergic reactions. Discontinue use immediately and seek medical attention if symptoms of an allergic reaction occur.
Interactions with Durlaza
Common Drug Interactions
- Anticoagulants: Combining Durlaza with anticoagulants like warfarin or heparin increases the risk of bleeding.
- Nonsteroidal anti-inflammatory drugs (NSAIDs): Taking other NSAIDs with Durlaza may increase the risk of gastrointestinal bleeding.
- Corticosteroids: These medications may increase the risk of stomach ulcers or bleeding when taken with Durlaza.
Alternatives to Durlaza
- Aspirin (standard formulation): Low-dose aspirin (81 mg or 325 mg) is used for similar cardiovascular protection but requires more frequent dosing.
- Clopidogrel (Plavix): An antiplatelet agent used to prevent blood clots in individuals with a history of cardiovascular disease or stroke.
- Ticagrelor (Brilinta): Another antiplatelet medication used to reduce the risk of heart attack and stroke in patients with acute coronary syndrome.
