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Duragesic-75
Duragesic-75 is a brand name for fentanyl transdermal patches, a powerful opioid pain medication used to manage severe chronic pain in individuals who require continuous, long-term opioid treatment and have developed a tolerance to other opioids. Fentanyl is a synthetic opioid that is significantly more potent than morphine. Duragesic-75 delivers 75 mcg of fentanyl per hour and is commonly prescribed for patients who need ongoing pain relief that cannot be managed by other pain medications.
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Frequently Asked Questions
How long does the Duragesic-75 patch last?
Each patch is designed to last for 72 hours (3 days), after which it should be replaced with a new one.
Can I cut the patch to adjust the dose?
No, the patch should never be cut, as this can cause an unsafe release of fentanyl, leading to overdose or death.
What should I do if the patch falls off early?
If the patch falls off before the 72-hour period is over, apply a new patch to a different skin area and continue with the normal schedule.
Can I use Duragesic-75 if I’m pregnant?
Fentanyl patches should be used with caution during pregnancy. Discuss with your doctor, as prolonged use can lead to neonatal opioid withdrawal syndrome.
What are the signs of fentanyl overdose?
Signs of overdose include extreme drowsiness, slow or shallow breathing, blue lips or fingernails, confusion, or loss of consciousness. Seek emergency medical help immediately if any of these symptoms occur.
Comprehensive Drug Guide
How Does Duragesic-75 Work?
Fentanyl in Duragesic-75 binds to mu-opioid receptors in the brain and spinal cord, altering the perception of pain and producing analgesia. By activating these receptors, it inhibits the transmission of pain signals in the nervous system, providing long-lasting pain relief. It also depresses the central nervous system, which accounts for its sedative effects.
Common Dosages
- 25 mcg/hour
- 50 mcg/hour
- 75 mcg/hour
- 100 mcg/hour The patches are designed for 72-hour wear and should be replaced every three days.
Typical Dosing
FDA Approved Indications
- Severe chronic pain requiring continuous opioid analgesia
- Pain that is unresponsive to other opioid treatments
- Pain in patients who are opioid-tolerant (i.e., those who have been using opioids for an extended period and require higher doses)
Who Shouldn't Take Duragesic-75?
- Patients who are not opioid-tolerant
- Individuals with severe respiratory depression
- Acute or severe asthma in an unmonitored setting
- Known hypersensitivity to fentanyl or any of the components in the patch
Advice From The Pharmacist
- Apply the patch to clean, dry, hairless skin on the chest, back, or upper arm. Do not apply the patch to broken, irritated, or damaged skin.
- Avoid exposing the patch to direct heat sources such as heating pads or hot baths, as this can increase fentanyl absorption and lead to overdose.
- Fold used patches in half, sticky sides together, and dispose of them safely according to local guidelines to avoid accidental exposure, especially to children or pets.
- Do not cut the patch, and do not use it for longer than 72 hours without replacing it.
Side Effects of Duragesic-75
Common Side Effects
- Constipation
- Nausea
- Drowsiness
- Dizziness
- Dry mouth
Uncommon/Severe Side Effects
- Severe hypotension
- Fainting
- Seizures
- Addiction and dependence
Risks and Warnings of Duragesic-75
- Addiction and Abuse: Fentanyl has a high potential for addiction, abuse, and misuse, which can lead to overdose and death.
- Respiratory Depression: Duragesic-75 can cause life-threatening respiratory depression, especially in patients who are not opioid-tolerant or in those who take other CNS depressants.
- Heat Exposure: Exposure to external heat sources can increase the release of fentanyl from the patch, leading to potentially fatal overdose.
- Accidental Exposure: Accidental exposure to fentanyl, especially in children or individuals without a prescription, can result in fatal overdose.
Interactions with Duragesic-75
Common Drug Interactions
- CNS Depressants: Concurrent use of alcohol, benzodiazepines, or other central nervous system depressants can increase the risk of sedation, respiratory depression, and death.
- Cytochrome P450 Inhibitors: Drugs that inhibit CYP3A4 (e.g., certain antibiotics or antifungal medications) can increase fentanyl levels in the blood, increasing the risk of serious side effects.
- Serotonergic Drugs: Using fentanyl with serotonergic medications (e.g., antidepressants) may increase the risk of serotonin syndrome.
Alternatives to Duragesic-75
- Morphine ER (extended-release): Another long-acting opioid used for managing severe pain in opioid-tolerant patients.
- OxyContin (oxycodone ER): A long-acting opioid used for continuous pain relief.
- Butrans (buprenorphine transdermal system): A transdermal opioid patch for moderate to severe chronic pain.
- Methadone: A synthetic opioid used for long-term pain management, particularly in patients with opioid dependence.
