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Duragesic-12

Duragesic-12 is the brand name for fentanyl transdermal system, a prescription opioid medication used to manage severe chronic pain in patients who require continuous, around-the-clock pain relief. It is commonly used when other pain treatments are not effective or tolerated. Fentanyl is a potent opioid analgesic, and the transdermal system (patch) allows for gradual absorption of the drug through the skin over a prolonged period. The "12" refers to the dosage, which delivers 12 mcg/hour of fentanyl.



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Frequently Asked Questions

How long does it take for Duragesic to start working?
Open FAQClose FAQ

It may take up to 24 hours for the full effect of the fentanyl patch to be felt, as the medication is slowly absorbed through the skin.

Can I shower or swim while wearing the Duragesic patch?
Open FAQClose FAQ

Yes, the patch is water-resistant and can stay on while showering or swimming. However, avoid prolonged exposure to water, as it may loosen the patch.

What should I do if my patch falls off early?
Open FAQClose FAQ

If the patch falls off before 72 hours, apply a new one to a different area of the skin and inform your healthcare provider, as this may indicate improper application or a need for a different patch size.

Is Duragesic-12 safe for long-term use?
Open FAQClose FAQ

Duragesic-12 is designed for long-term use in patients with chronic pain, but it requires regular monitoring by a healthcare provider to manage side effects and prevent addiction or misuse.

Can I use heating pads or hot showers while wearing the patch?
Open FAQClose FAQ

No, avoid exposing the patch to external heat sources such as heating pads, hot water bottles, or saunas, as this can increase the rate of fentanyl absorption and raise the risk of overdose.

Comprehensive Drug Guide

How Does Duragesic-12 Work?

Duragesic is available in the following strengths:

  • 12 mcg/hour patch (Duragesic-12)
  • 25 mcg/hour
  • 50 mcg/hour
  • 75 mcg/hour
  • 100 mcg/hour


Typical Dosing

FDA Approved Indications

  • Chronic pain in opioid-tolerant patients who require continuous, long-term pain management
  • Pain that cannot be adequately managed by alternative treatments like non-opioid medications or immediate-release opioids


Who Shouldn't Take Duragesic-12?

  • Patients who are opioid-naïve or do not have chronic pain requiring long-term opioid treatment
  • Acute pain, including post-operative or short-term pain
  • Severe respiratory conditions such as asthma or chronic obstructive pulmonary disease (COPD)
  • Known hypersensitivity to fentanyl or other ingredients in the patch


Advice From The Pharmacist

  • Always apply the patch to clean, dry skin on the upper arm, chest, or back. Avoid placing the patch on irritated or broken skin.
  • Do not cut or alter the patch, as this may cause the release of too much fentanyl too quickly.
  • Be cautious about exposure to heat (hot baths, heating pads), as this can increase the absorption of fentanyl and potentially lead to an overdose.
  • Safely dispose of used patches by folding them in half with the sticky sides together and flushing them down the toilet, as fentanyl patches can be dangerous if misused.


Side Effects of Duragesic-12

Common Side Effects

  • Nausea and vomiting
  • Drowsiness or sedation
  • Constipation
  • Sweating
  • Dizziness


Uncommon/Severe Side Effects

  • Respiratory depression (slow or shallow breathing)
  • Severe allergic reactions
  • Overdose, especially if patches are not used as directed
  • Dependence and addiction with long-term use

Risks and Warnings of Duragesic-12

  • Respiratory Depression: Fentanyl can slow or stop breathing, particularly in opioid-naïve patients or if used improperly. Monitoring for signs of overdose is crucial.
  • Addiction and Abuse: Duragesic is a highly potent opioid, and there is a significant risk of dependence and abuse. Use the patch exactly as prescribed and do not share it with others.
  • Accidental Exposure: Improper storage or disposal of the patch can lead to accidental exposure, especially in children, leading to life-threatening overdose.
  • Heat Exposure: Exposure to external heat sources, such as heating pads or hot tubs, can increase fentanyl absorption and cause an overdose.

Interactions with Duragesic-12

Common Drug Interactions

  • Other CNS depressants: Using Duragesic-12 with benzodiazepines, alcohol, or other central nervous system (CNS) depressants increases the risk of severe respiratory depression, sedation, and coma.
  • MAO inhibitors: These medications can intensify the effects of opioids and lead to dangerous interactions.
  • Anticholinergic drugs: These may increase the risk of urinary retention or severe constipation when used with opioids.

Alternatives to Duragesic-12

  • Morphine ER (extended-release): Another long-acting opioid used for managing chronic pain.
  • OxyContin (oxycodone ER): Extended-release oxycodone used for moderate to severe chronic pain.
  • Butrans (buprenorphine patch): A lower-strength opioid patch used for chronic pain in patients needing continuous relief.
  • Non-opioid alternatives: In some cases, medications like gabapentin, NSAIDs, or duloxetine may be considered for pain management.