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Duobrii
Duobrii is a topical lotion containing halobetasol propionate (a corticosteroid) and tazarotene (a retinoid) used to treat plaque psoriasis in adults. Halobetasol reduces inflammation, redness, and itching, while tazarotene helps normalize skin cell growth and reduces the scaling and thickness of plaques. This combination is effective for treating moderate to severe psoriasis by addressing both inflammation and excessive skin cell production.
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Frequently Asked Questions
How long does it take for Duobrii to work?
Improvement in psoriasis symptoms may be seen within 2 weeks, but it may take up to 8 weeks to achieve the full effect.
Can I use Duobrii on my face?
No, Duobrii should not be applied to the face, groin, or underarms, as these areas are more prone to irritation and thinning of the skin.
Can I stop using Duobrii once my psoriasis clears?
Yes, you should stop using Duobrii once your psoriasis plaques have cleared or after 8 weeks of use, whichever comes first.
Can Duobrii be used during pregnancy?
No, Duobrii should not be used during pregnancy, as it contains tazarotene, which can cause birth defects. Women of childbearing potential should use effective contraception while using this medication.
Can I use Duobrii with other psoriasis treatments?
It is best to consult your healthcare provider before combining Duobrii with other topical treatments, as this may increase the risk of side effects like skin irritation and photosensitivity.
Comprehensive Drug Guide
How Does Duobrii Work?
Duobrii combines two active ingredients: halobetasol, a potent corticosteroid that reduces inflammation, itching, and redness, and tazarotene, a retinoid that regulates skin cell production and helps reduce the abnormal thickening and scaling seen in plaque psoriasis.
Common Dosages
- Lotion: 0.01% halobetasol propionate and 0.045% tazarotene
Typical Dosing
- The typical dosing for Duobrii is to apply a thin layer of the lotion to the affected areas of the skin once daily. Treatment duration should be limited to 8 weeks, and use should be discontinued when psoriasis plaques clear.
Typical Dosing
FDA Approved Indications
- Plaque psoriasis in adults
Who Shouldn't Take Duobrii?
- Known hypersensitivity to halobetasol, tazarotene, or any other ingredients in the formulation
- Pregnancy, due to the risk of birth defects associated with tazarotene
Advice From The Pharmacist
- Apply a thin layer of Duobrii to the affected areas, but avoid using it on the face, groin, or underarms, as these areas are more prone to irritation.
- Wash your hands thoroughly after applying Duobrii.
- Avoid excessive exposure to sunlight or UV lamps while using Duobrii, as it can increase your skin’s sensitivity to the sun.
- If you are of childbearing potential, use effective contraception during treatment due to the potential risks associated with tazarotene.
Side Effects of Duobrii
Common Side Effects
- Skin irritation at the application site
- Dry skin
- Redness
- Itching
Uncommon/Severe Side Effects
- Skin thinning (atrophy) with prolonged use of corticosteroids
- Photosensitivity
- Severe irritation or rash
Risks and Warnings of Duobrii
- Skin Atrophy: Long-term use of halobetasol, a potent corticosteroid, can cause skin thinning, stretch marks, and easy bruising. Limit use to the prescribed duration.
- Photosensitivity: Duobrii can make your skin more sensitive to sunlight, increasing the risk of sunburn. Use sunscreen and protective clothing while using this medication.
- Pregnancy Risk: Tazarotene is a teratogenic drug, meaning it can cause birth defects if used during pregnancy. Women should avoid pregnancy while using Duobrii.
Interactions with Duobrii
Common Drug Interactions
- Other topical products: Using additional corticosteroids or retinoids on the same area can increase the risk of side effects such as skin irritation and thinning.
- Photosensitizing agents: Combining Duobrii with other medications that make your skin more sensitive to sunlight, such as tetracyclines, can increase the risk of sunburn.
Alternatives to Duobrii
- Taclonex: A combination of calcipotriene and betamethasone dipropionate for the treatment of plaque psoriasis.
- Enstilar: A foam formulation containing calcipotriene and betamethasone used for psoriasis.
- Clobetasol: A high-potency corticosteroid commonly used for psoriasis, available in various forms (cream, ointment, lotion).
