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Duaklir Pressair
Duaklir Pressair is a combination medication containing aclidinium bromide (a long-acting muscarinic antagonist or LAMA) and formoterol fumarate (a long-acting beta-agonist or LABA). It is used for the maintenance treatment of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. Duaklir Pressair helps to open the airways and make breathing easier by relaxing the muscles around the airways.
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Frequently Asked Questions
How long does it take for Duaklir Pressair to start working?
You may notice improvement in your breathing within a few hours after taking Duaklir Pressair, but the full effects are usually seen after a few weeks of regular use.
Can I use Duaklir Pressair for asthma?
No, Duaklir Pressair is not approved for the treatment of asthma and may increase the risk of asthma-related death. It is specifically for COPD maintenance treatment.
What should I do if I miss a dose of Duaklir Pressair?
If you miss a dose, take it as soon as you remember. If it is close to your next scheduled dose, skip the missed dose and take the next one at your regular time. Do not double up on doses.
Is Duaklir Pressair a rescue inhaler?
No, Duaklir Pressair is not a rescue inhaler and should not be used to relieve sudden breathing difficulties. Always carry a rescue inhaler, such as albuterol, for emergencies.
Can I stop using Duaklir Pressair if I feel better?
No, Duaklir Pressair is meant for long-term use in COPD management. Stopping the medication may lead to a worsening of symptoms. Always follow your healthcare provider's instructions.
Comprehensive Drug Guide
How Does Duaklir Pressair Work?
- Aclidinium bromide blocks muscarinic receptors in the airway smooth muscle, preventing bronchoconstriction (narrowing of the airways).
- Formoterol fumarate stimulates beta-2 adrenergic receptors, leading to relaxation of airway muscles and improved airflow.
Common Dosages
- Inhaler: Each actuation delivers 400 mcg of aclidinium bromide and 12 mcg of formoterol fumarate. It is typically used twice daily (one inhalation in the morning and one in the evening).
Typical Dosing
- For COPD maintenance: The typical dose is one inhalation twice daily, in the morning and evening, approximately 12 hours apart.
Typical Dosing
FDA Approved Indications
Duaklir Pressair is FDA-approved for the maintenance treatment of COPD, including chronic bronchitis and emphysema. It is not indicated for the relief of acute bronchospasm or asthma.
Who Shouldn't Take Duaklir Pressair?
- Known hypersensitivity to aclidinium, formoterol, or any of the other ingredients in the inhaler.
- Asthma (it is not indicated for asthma treatment and may increase the risk of asthma-related death).
Advice From The Pharmacist
- Use Duaklir Pressair exactly as prescribed, usually one inhalation twice daily.
- To use the inhaler, breathe in deeply and forcefully to ensure proper delivery of the medication to the lungs.
- Duaklir Pressair is for maintenance treatment and is not a rescue inhaler for sudden breathing problems. Always carry a rescue inhaler (such as albuterol) for emergency use.
- Rinse your mouth after using Duaklir Pressair to reduce the risk of oral infections, such as thrush.
- Store the inhaler at room temperature and keep it dry.
Side Effects of Duaklir Pressair
Common Side Effects
- Headache
- Cough
- Diarrhea
- Nasopharyngitis (inflammation of the nose and throat)
Uncommon/Severe Side Effects
- Paradoxical bronchospasm (worsening of breathing difficulties)
- Cardiovascular effects (increased heart rate, palpitations, high blood pressure)
- Hypersensitivity reactions (rash, itching, swelling)
Risks and Warnings of Duaklir Pressair
- Asthma-Related Death: LABAs, such as formoterol, have been associated with an increased risk of asthma-related death. Duaklir Pressair is not approved for the treatment of asthma.
- Paradoxical Bronchospasm: Some patients may experience worsening of breathing immediately after using Duaklir Pressair. Discontinue use and seek immediate medical attention if this occurs.
- Cardiovascular Risks: Use with caution in patients with cardiovascular conditions such as hypertension or arrhythmias, as formoterol can increase heart rate and blood pressure.
Interactions with Duaklir Pressair
Common Drug Interactions
- Beta-blockers: Medications such as propranolol may reduce the effectiveness of formoterol.
- Other anticholinergics: Combining Duaklir Pressair with other anticholinergic drugs can increase the risk of side effects like dry mouth or urinary retention.
- Diuretics: Use with diuretics (such as furosemide) may increase the risk of low potassium levels, leading to potential heart rhythm disturbances.
Alternatives to Duaklir Pressair
- Anoro Ellipta: A combination of umeclidinium and vilanterol, another LAMA/LABA combination used for the maintenance treatment of COPD.
- Stiolto Respimat: A combination of tiotropium and olodaterol, used for long-term maintenance of COPD.
- Symbicort (budesonide/formoterol): A combination of a steroid and LABA, used for COPD and asthma.
