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Dsuvia
Dsuvia (generic name: sufentanil sublingual tablet) is an opioid analgesic used to treat acute pain that is severe enough to require opioid treatment in a medically supervised setting. It is a highly potent opioid that provides rapid pain relief and is typically used in settings like emergency departments, post-surgical recovery, and battlefield environments. Dsuvia is classified as a Schedule II controlled substance due to its high potential for abuse and addiction.
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Frequently Asked Questions
How quickly does Dsuvia work?
Dsuvia provides pain relief within 15-30 minutes after administration, due to its rapid absorption under the tongue.
Can Dsuvia be used at home?
No, Dsuvia is intended for use only in certified healthcare settings due to the need for close monitoring and its high risk of respiratory depression and misuse.
How long can I be treated with Dsuvia?
Dsuvia is intended for short-term use in acute pain settings. Long-term use increases the risks of dependence, addiction, and respiratory complications.
Is Dsuvia stronger than fentanyl?
Yes, sufentanil (the active ingredient in Dsuvia) is more potent than fentanyl and should be used with extreme caution under strict medical supervision.
What should I do if I experience breathing problems after receiving Dsuvia?
Seek immediate medical attention if you experience difficulty breathing, slow or shallow breaths, or extreme drowsiness after receiving Dsuvia.
Comprehensive Drug Guide
How Does Dsuvia Work?
Dsuvia works by binding to the mu-opioid receptors in the brain and spinal cord, altering the perception of pain. As an opioid, it affects how the brain and nervous system respond to pain, providing significant relief in acute pain situations. Sufentanil, the active ingredient, is more potent than other opioids like morphine or fentanyl.
Common Dosages
- Sublingual tablets: 30 mcg
Typical Dosing
- The typical dosing for Dsuvia is one sublingual tablet (30 mcg) placed under the tongue as needed for acute pain. The administration is repeated every 1-3 hours as required, with a maximum daily dose determined by healthcare providers based on the patient's condition.
Typical Dosing
FDA Approved Indications
- Acute pain that is severe enough to require opioid analgesics and for which alternative treatments are inadequate.
Who Shouldn't Take Dsuvia?
- Severe respiratory depression
- Acute or severe asthma in an unmonitored setting
- Known hypersensitivity to sufentanil or other opioids
- Gastrointestinal obstruction, including paralytic ileus
Advice From The Pharmacist
- Dsuvia is administered only by healthcare professionals in a controlled setting, such as a hospital or surgery center.
- Inform your healthcare provider about any history of substance abuse, breathing problems, or liver or kidney disease before receiving Dsuvia.
- Dsuvia can cause drowsiness, dizziness, or impaired thinking, so avoid driving or operating machinery after receiving the medication.
- Dsuvia is intended for short-term use and should not be used outside of a monitored healthcare setting.
Side Effects of Dsuvia
Common Side Effects
- Drowsiness
- Nausea
- Headache
- Constipation
Uncommon/Severe Side Effects
- Respiratory depression
- Low blood pressure
- Bradycardia (slow heart rate)
- Severe allergic reactions (rash, swelling, difficulty breathing)
Risks and Warnings of Dsuvia
- Respiratory Depression: Dsuvia can cause serious or life-threatening breathing problems. Monitoring is required, especially in patients with underlying respiratory conditions.
- Addiction and Abuse: Dsuvia has a high potential for abuse and addiction due to its potency. It should only be used under strict medical supervision.
- Serotonin Syndrome: Dsuvia may increase the risk of serotonin syndrome when used with certain medications, such as SSRIs or SNRIs.
Interactions with Dsuvia
Common Drug Interactions
- Benzodiazepines: Combining Dsuvia with benzodiazepines or other CNS depressants may result in profound sedation, respiratory depression, coma, or death.
- SSRIs/SNRIs: Concurrent use can increase the risk of serotonin syndrome.
- CYP3A4 inhibitors: Drugs that inhibit CYP3A4, such as ketoconazole, can increase sufentanil levels and the risk of side effects.
Alternatives to Dsuvia
- Fentanyl: Another potent opioid analgesic used for severe pain, available as IV, transdermal, or lozenge formulations.
- Morphine: A widely used opioid for acute and chronic severe pain, available in multiple formulations.
- Oxycodone: A potent opioid often used for severe pain management in various settings.
