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Desvenlafaxine ER
Desvenlafaxine is an antidepressant drug used in the management of major depressive disorder. It works by helping restore the balance of serotonin and norepinephrine, in the brain, helping to improve mood, feelings of well-being, and energy level.
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Frequently Asked Questions
How quickly does desvenlafaxine work?
It's not recommended. Drinking alcohol can increase certain side effects of desvenlafaxine like dizziness and drowsiness.
I missed a dose of desvenlafaxine, what should I do?
Desvenlafaxine often takes several weeks to start working. It's important to continue taking it even if you don't notice improvements right away.
Can I just stop taking desvenlafaxine once I feel better?
Take your dose as soon as you remember, but do not take two doses at once. Just skip the missed dose if it s almost time for your next regularly scheduled dose.
Does desvenlafaxine affect my sexual performance?
No, never stop desvenlafaxine abruptly. The medication is what allows you to feel better and stopping it abruptly will not only put you at risk for withdrawal symptoms but it will cause your depression to return. Your doctor will guide you on how to safely taper off the medication.
Comprehensive Drug Guide
How Does Desvenlafaxine ER Work?
Desvenlafaxine is a Serotonin-Norepinephrine Reuptake Inhibitor (SNRI).It works by not allowing serotonin and norepinephrine to be reabsorbed in the brain. This allows for more of these chemicals to be in the brain at one time. The benefit to this is that with higher amounts of serotonin and norepinephrine in the brain it will feel more balanced and energized.
What is Desvenlafaxine ER Used For?
FDA indications: Desvenlafaxine is primarily used for the treatment of Major Depressive Disorder (MDD).
Off-label uses: In some cases, your healthcare provider might employ Desvenlafaxine to manage symptoms of menopause, or to treat nerve pain.
Common Dosages
Desvenlafaxine is commonly manufactured in tablet formulations of 50mg and 100mg
Typical Dosing
FDA Approved Indications
- Major Depressive Disorder: Typically, the starting dose is 50mg once per day. Depending on your individual situation and tolerance, your doctor may adjust the dose accordingly.
- Max dosage of 400mg/day
Who Shouldn't Take Desvenlafaxine ER?
- Those who are allergic to desvenlafaxine or venlafaxine.
- Individuals who are currently taking monoamine oxidase inhibitors (MAOIs) or have taken them within the past 14 days.
- Those who have untreated narrow-angle glaucoma.
- Those who are in the third trimester of pregnancy, unless instructed by a primary care provider.
- Individuals with a history of bipolar disorder or mania, unless closely monitored by a healthcare provider. These can put the patient at a higher risk of suicidal ideation.
- Individuals who have a history of suicidal ideation or behavior.
Advice From The Pharmacist
- Do not stop taking desvenlafaxine abruptly to avoid withdrawal symptoms. Always follow your prescriber's instructions when it comes to changing doses or stopping medication.
- Desvenlafaxine can be taken with or without food, but it is best to take it at the same time each day to maintain steady levels of the medication in your body.
- Avoid alcohol while taking desvenlafaxine, as it can increase your risk of experiencing side effects.
- Monitor your mood and seek help if you experience any new or worsening depressive symptoms or suicidal thoughts.
- Inform your healthcare provider if you become pregnant or plan to become pregnant while taking Desvenlafaxine. They will discuss the best course of action with you, considering both your health and the health of your baby.
- Try to engage in regular physical activity and implement a healthy balanced diet into your routine to prevent potential weight gain while taking Desvenlafaxine.
Side Effects of Desvenlafaxine ER
Common Side Effects
- You might experience nausea and may even vomit
- You may feel some dizziness or lightheadedness, especially when getting up
- Your mouth may feel dry, leading to a constant thirst
- You may sweat more than usual and might feel hot and flushed.
Uncommon/Severe Side Effects
- Unusual or severe stomach or abdominal pain might indicate a serious problem.
- Yellowing of the eyes or skin could indicate liver issues.
- You might experience eye pain or significant vision changes.
- You might have seizures.
Risks and Warnings of Desvenlafaxine ER
- Desvenlafaxine should be used only after careful consideration in patients with a history of seizures or mania.
- If you have high blood pressure, it?s important to regularly check your blood pressure while taking Desvenlafaxine as it may cause blood pressure to increase.
- This medication should be used with caution if you have a history of glaucoma.
- Desvenlafaxine can cause sexual dysfunction and may exacerbate existing symptoms.
- This medication can cause an increase in cholesterol and triglyceride levels. Regular monitoring of these levels might be required.
- Lastly, the stopping of Desvenlafaxine, especially when abrupt, can cause withdrawal symptoms, so it should always be done under the guidance of your doctor.
Interactions with Desvenlafaxine ER
Common Drug Interactions
- Monoamine oxidase inhibitors (MAOIs)
- Other SNRIs or SSRIs
- St. John's wort
- Triptans
- Certain blood thinners
- Certain pain medication
- Certain heart medications
Alternatives to Desvenlafaxine ER
- Venlafaxine
- Duloxetine
- Fluoxetine
- Sertraline
- Citalopram
