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Desogestrel-Ethinyl Estradiol
Desogestrel-Ethinyl Estradiol is a combination oral contraceptive containing desogestrel (a progestin) and ethinyl estradiol (an estrogen). It is primarily used to prevent pregnancy by inhibiting ovulation, thickening cervical mucus, and altering the uterine lining, making it difficult for sperm to reach an egg and for a fertilized egg to implant. Desogestrel-Ethinyl Estradiol may also help regulate menstrual cycles, reduce the risk of ovarian cysts, and treat moderate acne in women who also desire contraception.
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Frequently Asked Questions
What should I do if I miss a pill?
If you miss one active pill, take it as soon as you remember. If you miss two or more active pills, follow the instructions in the package insert and use backup contraception for the next 7 days.
Can Desogestrel-Ethinyl Estradiol protect against sexually transmitted infections (STIs)?
No, Desogestrel-Ethinyl Estradiol does not protect against STIs. You should use condoms or other barrier methods to reduce the risk of STIs.
How long does it take for Desogestrel-Ethinyl Estradiol to become effective?
It is effective immediately if you start taking Desogestrel-Ethinyl Estradiol within the first five days of your menstrual cycle. If you start at another time, use backup contraception for the first seven days.
Can Desogestrel-Ethinyl Estradiol cause weight gain?
Weight gain is a possible side effect, though not all women will experience it. Maintaining a balanced diet and regular exercise may help manage weight changes.
Is Desogestrel-Ethinyl Estradiol safe for long-term use?
Desogestrel-Ethinyl Estradiol is safe for long-term use under medical supervision. Regular check-ups are recommended to monitor for side effects and assess overall health.
Comprehensive Drug Guide
How Does Desogestrel-Ethinyl Estradiol Work?
Desogestrel-Ethinyl Estradiol works by preventing ovulation through the combined effects of ethinyl estradiol and desogestrel. These hormones inhibit the release of gonadotropins (FSH and LH) from the pituitary gland, which prevents the release of an egg. Additionally, the medication thickens cervical mucus and changes the uterine lining to prevent sperm from reaching the egg and implantation.
What is Desogestrel-Ethinyl Estradiol Used For?
- Prevention of pregnancy
- Regulation of menstrual cycles
- Treatment of moderate acne in women seeking contraception
Common Dosages
Desogestrel-Ethinyl Estradiol is available in 28-day packs:
- 21 active tablets: Each contains 0.15 mg desogestrel and 30 mcg ethinyl estradiol.
- 7 inactive tablets (placebo): Taken during the last week of the cycle.
Typical Dosing
FDA Approved Indications
- Take one active tablet daily for 21 days, followed by one inactive tablet daily for 7 days. For maximum effectiveness, take the pill at the same time every day.
Who Shouldn't Take Desogestrel-Ethinyl Estradiol?
Desogestrel-Ethinyl Estradiol should not be used in individuals with:
- A history of blood clots, stroke, or heart attack
- Uncontrolled hypertension
- Known or suspected breast cancer
- Liver disease or liver tumors
- Undiagnosed abnormal vaginal bleeding
- Known hypersensitivity to desogestrel, ethinyl estradiol, or any component of the formulation
Advice From The Pharmacist
- Take Desogestrel-Ethinyl Estradiol at the same time each day to maintain consistent hormone levels and maximize its effectiveness in preventing pregnancy.
- If you miss a pill, refer to the instructions in the package insert or consult your healthcare provider. If you miss two or more active pills, use backup contraception, such as condoms, for the next 7 days.
- This medication does not protect against sexually transmitted infections (STIs). Use condoms or other barrier methods for STI protection.
Side Effects of Desogestrel-Ethinyl Estradiol
Common Side Effects
- Nausea
- Breast tenderness
- Headache
- Weight gain
- Mood changes
Uncommon/Severe Side Effects
- Blood clots (deep vein thrombosis, pulmonary embolism)
- Stroke
- Heart attack
- Liver problems (e.g., jaundice)
Risks and Warnings of Desogestrel-Ethinyl Estradiol
Blood Clots: Desogestrel-Ethinyl Estradiol increases the risk of blood clots, especially in women who smoke and are over 35 years old. Smoking cessation is strongly recommended while using this contraceptive.
Cardiovascular Risks: Women with heart disease or high blood pressure should use this medication cautiously, as it may increase the risk of heart attack or stroke.
Breast Cancer Risk: Hormonal contraceptives may slightly increase the risk of breast cancer, particularly in women with a family history of the disease. Regular breast exams and screenings are recommended.
Interactions with Desogestrel-Ethinyl Estradiol
Common Drug Interactions
- Antibiotics (e.g., rifampin) may reduce the effectiveness of Desogestrel-Ethinyl Estradiol. Use backup contraception while taking antibiotics.
- Anticonvulsants: Certain anticonvulsant medications may decrease the efficacy of hormonal contraceptives.
- St. John’s Wort: This herbal supplement may reduce the effectiveness of Desogestrel-Ethinyl Estradiol.
Alternatives to Desogestrel-Ethinyl Estradiol
- Ortho-Cept: Another combination oral contraceptive with the same active ingredients.
- NuvaRing: A vaginal ring that provides a combination of estrogen and progestin for contraception.
- Depo-Provera: A long-acting injectable contraceptive administered every 12 weeks.
- IUDs: Long-term contraceptive options such as Mirena (hormonal) or ParaGard (copper), which do not require daily dosing.
