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Depakote Sprinkles
Depakote Sprinkles (divalproex sodium delayed-release capsules) is an anticonvulsant and mood stabilizer used to treat seizure disorders, bipolar disorder, and to prevent migraine headaches. This formulation allows the capsules to be opened and sprinkled onto soft foods, making it easier to administer, especially for patients who have difficulty swallowing. Depakote Sprinkles work by increasing certain chemicals in the brain that help prevent seizures and stabilize mood.
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Frequently Asked Questions
How long does it take for Depakote Sprinkles to start working?
For seizure control or mood stabilization, it may take several days to weeks to see the full benefits. For migraine prevention, it may take a few weeks to notice a reduction in headaches.
Can I stop taking Depakote Sprinkles if I feel better?
Do not stop taking Depakote Sprinkles suddenly, as this can lead to withdrawal symptoms or a return of seizures. Always consult your healthcare provider before making any changes to your treatment plan.
Are Depakote Sprinkles safe to use during pregnancy?
No, Depakote is associated with a high risk of birth defects and developmental issues if taken during pregnancy. Women of childbearing potential should use effective contraception and discuss pregnancy risks with their doctor.
What should I do if I miss a dose of Depakote Sprinkles?
If you miss a dose, take it as soon as you remember. If it is close to your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take two doses at once.
Can Depakote Sprinkles cause weight gain?
Yes, weight gain is a common side effect of Depakote. Maintaining a balanced diet and regular physical activity may help manage this effect.
Comprehensive Drug Guide
How Does Depakote Sprinkles Work?
Depakote Sprinkles work by increasing levels of gamma-aminobutyric acid (GABA), a neurotransmitter that helps calm nerve activity in the brain. This helps control seizures and stabilize mood in patients with bipolar disorder. Additionally, it helps prevent migraines by stabilizing electrical activity in the brain.
What is Depakote Sprinkles Used For?
- Seizure disorders (partial, generalized, and absence seizures)
- Bipolar disorder (manic episodes)
- Migraine prevention
Common Dosages
Depakote Sprinkles are available by prescription as delayed-release capsules. They are not classified as a controlled substance.
- 125 mg delayed-release capsules
Typical Dosing
FDA Approved Indications
- For seizure disorders, the starting dose is typically 10 to 15 mg/kg per day, which may be gradually increased based on clinical response.
- For bipolar disorder, the recommended dose is 750 mg daily, which may be adjusted based on individual response.
- For migraine prevention, the initial dose is 250 mg twice daily, with possible adjustments depending on effectiveness and tolerance.
Who Shouldn't Take Depakote Sprinkles?
Depakote Sprinkles should not be used in individuals with:
- Liver disease
- Mitochondrial disorders
- Known hypersensitivity to divalproex sodium
- Urea cycle disorders
Advice From The Pharmacist
- Depakote Sprinkles can be swallowed whole or sprinkled onto soft food like applesauce. Do not chew the capsules or the sprinkled contents.
- Regular blood tests may be necessary to monitor liver function and drug levels while taking Depakote Sprinkles.
- Avoid alcohol while taking Depakote, as it can increase the risk of liver damage and affect the medication’s effectiveness.
Side Effects of Depakote Sprinkles
Common Side Effects
- Nausea
- Drowsiness
- Dizziness
- Tremors
- Weight gain
Uncommon/Severe Side Effects
- Liver toxicity
- Pancreatitis
- Thrombocytopenia (low platelet count)
- Severe allergic reactions (e.g., rash, swelling, difficulty breathing)
Risks and Warnings of Depakote Sprinkles
Liver Toxicity: Depakote Sprinkles can cause severe liver damage, especially in children under 2 years of age and patients with pre-existing liver conditions. Regular monitoring of liver function is necessary.
Pancreatitis: This medication can cause life-threatening pancreatitis. Report any sudden abdominal pain, nausea, or vomiting to your healthcare provider immediately.
Teratogenicity: Depakote carries a high risk of birth defects if taken during pregnancy. Women of childbearing age should use effective contraception and discuss pregnancy risks with their healthcare provider.
Interactions with Depakote Sprinkles
Common Drug Interactions
- Blood thinners (e.g., warfarin): Depakote can increase the risk of bleeding.
- Other anticonvulsants: Using Depakote with other seizure medications may alter drug levels, requiring dosage adjustments.
- Antidepressants: Certain antidepressants may interact with Depakote, increasing the risk of side effects or affecting its efficacy.
Alternatives to Depakote Sprinkles
- Lamotrigine: An anticonvulsant used for seizure disorders and bipolar disorder.
- Topiramate: Used for seizure control and migraine prevention.
- Lithium: A mood stabilizer commonly used for bipolar disorder.
- Carbamazepine: Another anticonvulsant and mood stabilizer used for similar conditions.
