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Darifenacin Hydrobromide ER

Darifenacin Hydrobromide ER is a muscarinic receptor antagonist (anticholinergic) used to treat overactive bladder (OAB) symptoms, such as frequent urination, urge incontinence, and urgency. It works by relaxing the muscles of the bladder, reducing the urge to urinate and increasing bladder capacity. The extended-release (ER) formulation allows for once-daily dosing, offering sustained relief from OAB symptoms.

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Frequently Asked Questions

How long does it take for Darifenacin to start working?
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Most patients start to notice improvement in bladder symptoms within two weeks, but full effects may take up to eight weeks.

Can I stop taking Darifenacin if my symptoms improve?
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Do not stop taking Darifenacin without consulting your doctor, as your symptoms may return. Follow your doctor’s instructions on managing your condition.

What should I do if I miss a dose of Darifenacin?
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If you miss a dose, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up doses

Is Darifenacin safe for long-term use?
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Darifenacin can be used long-term under the supervision of your healthcare provider. Regular check-ups are recommended to monitor for any potential side effects or complications.

Can Darifenacin cause weight gain?
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Weight gain is not a common side effect of Darifenacin, but some patients may experience changes in appetite or activity levels due to the relief of bladder symptoms. Consult your doctor if you notice significant weight changes.

Comprehensive Drug Guide

How Does Darifenacin Hydrobromide ER Work?

Darifenacin works by selectively blocking M3 muscarinic receptors, which are involved in bladder muscle contractions. By inhibiting these receptors, Darifenacin reduces involuntary bladder contractions, thereby decreasing urinary frequency, urgency, and urge incontinence.

What is Darifenacin Hydrobromide ER Used For?

Treatment of overactive bladder with symptoms of urge incontinence, urgency, and urinary frequency.

Common Dosages

Darifenacin Hydrobromide ER is available by prescription in the form of extended-release tablets. It is not classified as a controlled substance.

  • 7.5 mg extended-release tablets
  • 15 mg extended-release tablets

Typical Dosing

FDA Approved Indications

The usual starting dose is 7.5 mg once daily, with the dose possibly increased to 15 mg once daily based on patient response and tolerance. Tablets should be swallowed whole and not crushed or chewed.

Who Shouldn't Take Darifenacin Hydrobromide ER?

Darifenacin should not be used in individuals with:

  • Urinary retention
  • Gastric retention or severe gastrointestinal conditions
  • Uncontrolled narrow-angle glaucoma
  • Known hypersensitivity to darifenacin or any of its components


Advice From The Pharmacist

  • Take Darifenacin Hydrobromide ER at the same time each day, with or without food.
  • Avoid alcohol, as it can exacerbate side effects such as drowsiness or dizziness.
  • Drink plenty of fluids to stay hydrated, especially if experiencing dry mouth or constipation, which are common side effects of anticholinergics.
  • Do not crush or chew the tablets, as this may alter the extended-release mechanism and increase the risk of side effects.


Side Effects of Darifenacin Hydrobromide ER

Common Side Effects

  • Dry mouth
  • Constipation
  • Blurred vision
  • Dizziness
  • Dry eyes


Uncommon/Severe Side Effects

  • Severe constipation or difficulty urinating
  • Severe allergic reactions (e.g., rash, swelling, difficulty breathing)
  • Confusion or hallucinations (rare but possible in older adults)


Risks and Warnings of Darifenacin Hydrobromide ER

Cognitive Impairment: Darifenacin may cause confusion, memory issues, or hallucinations, particularly in elderly patients. Use with caution in this population.

Heat Prostration: Anticholinergics can reduce sweating, leading to heat prostration during hot weather or strenuous exercise. Stay hydrated and avoid excessive heat exposure.

Constipation: Prolonged use of Darifenacin may worsen or cause severe constipation. If you experience difficulty passing stool, contact your healthcare provider.

Interactions with Darifenacin Hydrobromide ER

Common Drug Interactions

  • Other anticholinergics: Concurrent use with other anticholinergic drugs (e.g., oxybutynin) can increase the risk of side effects such as dry mouth, blurred vision, and urinary retention.
  • CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): These medications may increase the levels of Darifenacin in the body, leading to a higher risk of side effects.
  • CYP2D6 substrates: Darifenacin may interact with drugs metabolized by CYP2D6, such as metoprolol and antidepressants.

Alternatives to Darifenacin Hydrobromide ER

  • Oxybutynin: Another anticholinergic used to treat overactive bladder symptoms.
  • Tolterodine: A muscarinic antagonist that works similarly to Darifenacin.
  • Mirabegron: A beta-3 agonist used to treat overactive bladder without the typical anticholinergic side effects like dry mouth.