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Dapsone
Dapsone is a widely versatile and powerful medication that's primarily used to treat leprosy, cystic acne, and several acute inflammatory diseases. While it may cause some side effects like nausea, dizziness, or an increase in sensitivity to sunlight, your doctor will balance these aspects to ensure maximum benefit.
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Frequently Asked Questions
Can I just stop taking Dapsone once my symptoms are gone?
No, it's always essential to complete the full course of the medication, even if your symptoms have disappeared. Stopping Dapsone suddenly could lead to a relapse or resistance in the bacteria.
Can I take Dapsone if I have G6PD deficiency?
In general, no. People with G6PD deficiency may experience hemolysis (the destruction of red blood cells), which can cause serious health effects. Always consult your doctor for advice.
Does Dapsone make me more sensitive to sunlight?
Yes, it does. Avoid excessive sun exposure and always protect your skin with a broadspectrum sunscreen.
I missed a dose of Dapsone; what should I do?
If it's close to the time for your next dose, skip the missed dose. However, if there's still a lot of time for the next dose, take it as soon as you remember.
Comprehensive Drug Guide
How Does Dapsone Work?
Dapsone is a sulfone antibiotic that inhibits the synthesis of dihydrofolic acid, impeding bacterial growth.
What is Dapsone Used For?
FDA indications: Dapsone is used to treat leprosy and dermatitis herpetiformis. It may also be used to treat severe acne.
Offlabel uses: It has been used in the offlabel treatment of certain types of vasculitis and rheumatoid arthritis.
Common Dosages
Tablets: 25mg, 50mg, 100mg
Typical Dosing
FDA Approved Indications
- For FDAapproved indications:
- Leprosy: 50100mg per day.
- Dermatitis herpetiformis: 50200mg per day (used together with a glutenfree diet).
- Severe acne: Apply a thin layer of topical Dapsone to the affected area once daily.
Off-Label Uses
- Vasculitis: Dosage is based on the severity of the condition and doctor's recommendations.
- Rheumatoid arthritis: 50200mg per day.
Who Shouldn't Take Dapsone?
- Those with known hypersensitivity to Dapsone or any of its constituents.
- Individuals who have Glucose6phosphate dehydrogenase (G6PD) deficiency.
- Patients with marked liver damage.
- Those with severe anemia.
Advice From The Pharmacist
- Dapsone might make you more sensitive to the sun. Limit your sun exposure and wear sunscreen.
- Always take Dapsone consistently, preferably at the same time each day.
- Contact your doctor if your condition does not improve or if it worsens.
- Dapsone can cause methemoglobinemia, a condition that reduces the amount of oxygen carried by your blood. Consult your doctor if you notice symptoms such as blue/gray lips or nails, shortness of breath, or fatigue.
- Avoid alcoholthey can increase the risk of liver damage.
- Ensure to keep your doctor's appointments and get regular blood tests.
- Pregnant women should discuss the risks and benefits of Dapsone with their healthcare
Side Effects of Dapsone
Common Side Effects
- Common side effects:
- You might feel nauseous, dizzy, or vomited.
- You may notice a mild rash.
- Slight sensitivity to sunlight.
- Rare side effects:
- Dark urine
- Severe abdominal or stomach pain
- Severe skin rash.
- Yellow eyes or skin
- Severe side effects:
- Signs of blood disorders such as unusual tiredness, pale skin, or dark urine.
- Signs of severe allergic reactions such as itching, rashes, or difficulty breathing.
Risks and Warnings of Dapsone
- Dapsone should be avoided by individuals with known hypersensitivity to the medication or its constituents.
- Caution is advised if you have G6PD deficiency, severe anemia, or debilitating diseases.
- Regular blood tests are recommended during treatment to monitor your hemoglobin levels.
- Avoid exposure to direct sunlight due to a risk of photosensitivity. Always wear protective clothing and use a broadspectrum sunscreen when outdoors.
- Stop taking Dapsone and consult your doctor immediately if you experience signs of blood disorders or severe allergic reactions.
Interactions with Dapsone
Common Drug Interactions
- Trimethoprim
- Primaquine
- Pyrimethamine
- Clofazimine
- Rifampin
Alternatives to Dapsone
- Clofazimine
- Rifampin
- Tofacitinib
- Secukinumab
- Ixekizumab
