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Cuvposa
Cuvposa (glycopyrrolate) is an anticholinergic medication used to treat chronic severe drooling (sialorrhea) in children aged 3 to 16 years with certain neurological conditions, such as cerebral palsy. It works by reducing the production of saliva. Cuvposa is commonly prescribed to manage drooling that interferes with daily activities, speech, and swallowing.
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Frequently Asked Questions
How long does it take for Cuvposa to start working?
Cuvposa may begin reducing drooling within a few days to a week, but it may take several weeks for the full effect to be seen.
Can Cuvposa cause constipation?
Yes, constipation is a common side effect of Cuvposa. Make sure your child stays hydrated and consult your healthcare provider if constipation becomes severe.
What should I do if my child misses a dose of Cuvposa?
If a dose is missed, give it as soon as you remember, unless it is close to the time of the next dose. Do not double up doses.
Can Cuvposa be used in children younger than 3 years old?
Cuvposa is approved for use in children aged 3 to 16 years. Its safety and effectiveness in children younger than 3 have not been established.
Is Cuvposa safe for long-term use?
Yes, Cuvposa is generally safe for long-term use when monitored by a healthcare provider. However, regular follow-up appointments are necessary to assess for side effects and adjust the dose if needed.
Comprehensive Drug Guide
How Does Cuvposa Work?
Cuvposa works by blocking acetylcholine, a neurotransmitter that stimulates the salivary glands to produce saliva. By inhibiting acetylcholine, Cuvposa reduces saliva production, helping to control excessive drooling.
Common Dosages
- Oral solution: 1 mg/5 mL
Typical Dosing
- The typical starting dose of Cuvposa is 0.02 mg/kg, taken three times daily. The dose may be adjusted based on response and tolerability, with a maximum dose of 0.1 mg/kg three times daily.
Typical Dosing
FDA Approved Indications
- Chronic severe drooling (sialorrhea) in children aged 3 to 16 years with neurological conditions such as cerebral palsy.
Who Shouldn't Take Cuvposa?
- Known hypersensitivity to glycopyrrolate or any component of the formulation.
- Glaucoma, particularly angle-closure glaucoma.
- Myasthenia gravis.
- Urinary retention or severe gastrointestinal obstruction.
Advice From The Pharmacist
- Cuvposa should be taken on an empty stomach to improve absorption. Do not give the medication with food.
- If a dose is missed, take it as soon as possible, but skip the missed dose if it is close to the next scheduled dose. Do not double up on doses.
- Regular follow-up visits with the healthcare provider are important to monitor the child’s response and adjust the dose as needed.
Side Effects of Cuvposa
Common Side Effects
- Dry mouth
- Constipation
- Flushing
- Drowsiness
- Urinary retention
Uncommon/Severe Side Effects
- Severe constipation or bowel obstruction
- Blurred vision
- Dehydration
- Difficulty urinating
Risks and Warnings of Cuvposa
- Dehydration Risk: Since Cuvposa reduces saliva production, it can increase the risk of dehydration. Ensure that the child drinks enough fluids throughout the day.
- Constipation: Cuvposa can cause or worsen constipation. If severe constipation occurs, consult a healthcare provider.
- Vision Problems: Blurred vision or difficulty focusing can occur, especially in children with glaucoma or other eye conditions. Monitor for vision changes and report them to the healthcare provider.
Interactions with Cuvposa
Common Drug Interactions
- Anticholinergic drugs: Combining Cuvposa with other anticholinergics (e.g., diphenhydramine, atropine) can increase the risk of side effects like dry mouth, blurred vision, and urinary retention.
- Potassium supplements: Taking oral potassium supplements can increase the risk of gastric irritation when combined with anticholinergic medications like Cuvposa.
- Medications for glaucoma: Since Cuvposa can worsen glaucoma, avoid combining it with glaucoma medications without consulting a healthcare provider.
Alternatives to Cuvposa
- Scopolamine: An anticholinergic medication used to reduce drooling and motion sickness.
- Botulinum toxin (Botox) injections: Used in severe cases to reduce salivary gland activity and control excessive drooling.
- Atropine drops: Used sublingually in some cases to reduce saliva production.
