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Cryselle-28

Cryselle-28 is a combination oral contraceptive pill containing ethinyl estradiol (an estrogen) and norgestrel (a progestin). It is used to prevent pregnancy by inhibiting ovulation, thickening cervical mucus, and altering the uterine lining to make it more difficult for sperm to reach the egg and for a fertilized egg to attach. In addition to preventing pregnancy, Cryselle-28 may also be prescribed to regulate menstrual cycles, reduce the risk of ovarian cysts, and treat acne.

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Frequently Asked Questions

What should I do if I miss a pill?
Open FAQClose FAQ

If you miss one active pill, take it as soon as you remember, and take the next pill at your usual time. If you miss two or more active pills, follow the instructions on the package insert or consult your doctor.

Can Cryselle-28 protect against sexually transmitted infections (STIs)?
Open FAQClose FAQ

No, Cryselle-28 does not provide protection against STIs. Use condoms or another barrier method to prevent infections.

What happens if I take Cryselle-28 late or skip a dose?
Open FAQClose FAQ

If you take a pill late or skip a dose, the effectiveness of the birth control may decrease. Use an additional form of contraception (such as condoms) if you miss two or more pills in a row.

Can I take Cryselle-28 if I’m breastfeeding?
Open FAQClose FAQ

Cryselle-28 is generally not recommended for breastfeeding women, as it may reduce milk production. Consult your doctor for other contraceptive options.

When should I stop taking Cryselle-28?
Open FAQClose FAQ

You can stop taking Cryselle-28 if you wish to become pregnant or if directed by your healthcare provider. If you are switching to another form of contraception, consult your doctor for instructions on how to transition safely.

Comprehensive Drug Guide

How Does Cryselle-28 Work?

Cryselle-28 prevents pregnancy primarily by inhibiting ovulation through the combined effects of ethinyl estradiol and norgestrel. These hormones also thicken the cervical mucus to prevent sperm from entering the uterus and alter the uterine lining to prevent implantation of a fertilized egg.

What is Cryselle-28 Used For?

  • Prevention of pregnancy
  • Regulation of menstrual cycles
  • Treatment of moderate acne in women who also desire contraception

Common Dosages

Cryselle-28 is available by prescription as a 28-day oral contraceptive pack. It is not classified as a controlled substance.

  • Active pills: 21 white tablets containing 0.3 mg of norgestrel and 0.03 mg of ethinyl estradiol.
  • Inactive pills: 7 green placebo tablets taken during the last week of the cycle.


Typical Dosing

FDA Approved Indications

Take one active tablet daily for 21 days, followed by one inactive tablet daily for the next 7 days. This regimen is repeated each month. To maximize effectiveness, take the pill at the same time every day.


Who Shouldn't Take Cryselle-28?

Cryselle-28 should not be used in individuals with:

  • A history of blood clots, stroke, or heart attack
  • Uncontrolled hypertension
  • Known or suspected breast cancer
  • Liver disease or liver tumors
  • Known hypersensitivity to ethinyl estradiol, norgestrel, or any other component of the formulation


Advice From The Pharmacist

  • Take the pill at the same time every day to maintain consistent hormone levels and maximize pregnancy prevention.
  • If you miss a dose, follow the instructions on the package insert or consult your healthcare provider for guidance on how to proceed.
  • Use an additional form of contraception, such as condoms, if you miss two or more active pills in a row.
  • Store Cryselle-28 at room temperature and away from moisture and heat.
  • Cryselle-28 does not protect against sexually transmitted infections (STIs). Use a barrier method (e.g., condoms) for STI prevention.

Side Effects of Cryselle-28

Common Side Effects

  • Nausea
  • Breast tenderness
  • Headache
  • Weight gain
  • Mood changes


Uncommon/Severe Side Effects

  • Blood clots
  • Stroke
  • Heart attack
  • Liver problems (e.g., jaundice)


Risks and Warnings of Cryselle-28

Blood Clots: Cryselle-28 may increase the risk of developing blood clots, particularly in women who smoke or are over the age of 35. Women with a history of blood clots should not use this medication.

Cardiovascular Risks: Women with pre-existing heart conditions, hypertension, or a history of stroke should use this medication cautiously and under close medical supervision.

Breast Cancer: Hormonal contraceptives may increase the risk of breast cancer, especially in women with a family history or personal history of the disease.

Interactions with Cryselle-28

Common Drug Interactions

  • Antibiotics: Certain antibiotics, such as rifampin, may reduce the effectiveness of Cryselle-28.
  • Anticonvulsants: Medications like phenytoin and carbamazepine may decrease the contraceptive efficacy.
  • St. John’s Wort: This herbal supplement may lower the effectiveness of birth control pills.

Alternatives to Cryselle-28

  • Loestrin Fe: A combination oral contraceptive with a different hormonal composition.
  • Ortho Tri-Cyclen: Another oral contraceptive that is commonly prescribed to prevent pregnancy and treat acne.
  • Depo-Provera: A long-acting injectable contraceptive for women seeking alternatives to daily pills.