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Cresemba
Cresemba (generic name: isavuconazonium sulfate) is an antifungal medication used to treat severe fungal infections such as invasive aspergillosis and invasive mucormycosis, which are life-threatening fungal infections that typically affect people with weakened immune systems. Cresemba works by inhibiting fungal cell growth, effectively controlling and treating the infection.
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Frequently Asked Questions
How long does it take for Cresemba to start working?
Cresemba starts working soon after administration, but it may take several days to weeks to see full improvement, depending on the infection.
Can I take Cresemba with food?
Yes, Cresemba can be taken with or without food.
What should I do if I miss a dose of Cresemba?
Take the missed dose as soon as you remember. If it's almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not double up.
Is Cresemba safe for long-term use?
Cresemba is typically used for the duration of the fungal infection, which may vary in length. Regular monitoring by your healthcare provider is important to ensure its safety.
Can Cresemba cause liver problems?
Yes, Cresemba may cause liver toxicity, so regular blood tests are needed to monitor liver function during treatment.
Comprehensive Drug Guide
How Does Cresemba Work?
Cresemba works by inhibiting the synthesis of ergosterol, a key component of fungal cell membranes. By preventing the formation of ergosterol, Cresemba disrupts the fungal cell membrane's integrity, ultimately killing the fungus and stopping the spread of infection.
Common Dosages
- 186 mg oral capsules
- 372 mg powder for intravenous infusion
Typical Dosing
- For invasive fungal infections: The recommended starting dose is 372 mg administered intravenously every 8 hours for 6 doses (48 hours), followed by 186 mg orally or intravenously once daily.
- The duration of treatment depends on the severity of the infection and response to therapy.
Typical Dosing
FDA Approved Indications
- Invasive aspergillosis
- Invasive mucormycosis
Who Shouldn't Take Cresemba?
- Familial short QT syndrome
- Known hypersensitivity to isavuconazonium sulfate or any other components of the formulation
Advice From The Pharmacist
- Cresemba capsules should be swallowed whole and taken with or without food.
- If you are using Cresemba IV, it will be administered by a healthcare professional in a hospital setting.
- Inform your healthcare provider of any pre-existing heart conditions, as Cresemba can affect heart rhythm.
Side Effects of Cresemba
Common Side Effects
- Headache
- Nausea
- Vomiting
- Diarrhea
Uncommon/Severe Side Effects
- Liver toxicity: Signs include yellowing of the skin or eyes, dark urine, or upper abdominal pain.
- Heart rhythm problems: Cresemba may cause QT shortening, which can lead to abnormal heart rhythms.
Risks and Warnings of Cresemba
- Liver Damage: Cresemba may cause liver damage, so regular monitoring of liver function tests is important.
- Heart Rhythm Problems: Cresemba can cause QT shortening, which is an abnormal heart rhythm. Individuals with familial short QT syndrome should not use this medication.
Interactions with Cresemba
Common Drug Interactions
- Rifampin: This antibiotic can decrease the effectiveness of Cresemba.
- Ketoconazole: Using other antifungal drugs like ketoconazole with Cresemba may increase the risk of side effects.
- Immunosuppressants: Drugs like cyclosporine or tacrolimus may require dose adjustments when used with Cresemba.
Alternatives to Cresemba
- Voriconazole: Another antifungal used for treating invasive aspergillosis.
- Amphotericin B: A powerful antifungal used for invasive fungal infections.
- Posaconazole: An azole antifungal used to treat various severe fungal infections, including mucormycosis.