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Cortisporin-TC

Cortisporin-TC is a combination antibiotic and corticosteroid ear drop used to treat bacterial infections and inflammation in the ear. It contains neomycin, colistin, thonzonium, and hydrocortisone. Neomycin and colistin are antibiotics that kill bacteria, while hydrocortisone helps reduce inflammation. Thonzonium assists in breaking down earwax and improving the penetration of the active ingredients. This combination is commonly used to treat conditions such as otitis externa (swimmer’s ear) and other outer ear infections.

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Frequently Asked Questions

How long does it take for Cortisporin-TC to work?
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Most patients experience relief from symptoms within a few days, but the full course of treatment may last up to 7 to 10 days.

Can I use Cortisporin-TC if I have a perforated eardrum?
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No, Cortisporin-TC should not be used if you have a perforated eardrum. Contact your healthcare provider for alternative treatments.

What should I do if I miss a dose?
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If you miss a dose, apply it as soon as you remember. If it’s close to your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.

Can I use Cortisporin-TC during pregnancy?
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There is limited information about the use of Cortisporin-TC during pregnancy. Consult your healthcare provider if you are pregnant or planning to become pregnant while using this medication.

What should I do if my symptoms don’t improve after using Cortisporin-TC?
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If your symptoms do not improve after several days of using Cortisporin-TC, or if they worsen, contact your healthcare provider. You may need a different treatment or further evaluation.

Comprehensive Drug Guide

How Does Cortisporin-TC Work?

Cortisporin-TC works through a combination of its components:

  • Neomycin and Colistin: These antibiotics target and eliminate bacteria responsible for ear infections.
  • Hydrocortisone: A corticosteroid that reduces inflammation, swelling, and itching.
  • Thonzonium: A surface-active agent that helps break down earwax and improve the penetration of the medication into the ear canal.

What is Cortisporin-TC Used For?

Otitis externa (swimmer’s ear)

Bacterial ear infections involving the outer ear

Common Dosages

Cortisporin-TC is available by prescription as an otic solution (ear drops). It is not classified as a controlled substance.

Typical Dosing

FDA Approved Indications

For otitis externa or other outer ear infections: Apply the prescribed number of drops (usually 4 drops) into the affected ear 3 to 4 times daily, for up to 10 days, or as directed by your healthcare provider.

Who Shouldn't Take Cortisporin-TC?

Cortisporin-TC should not be used in individuals with:

  • A perforated eardrum
  • Viral or fungal ear infections
  • Hypersensitivity to neomycin, colistin, hydrocortisone, thonzonium, or any other ingredients in the formulation


Advice From The Pharmacist

  • Warm the bottle in your hands for a few minutes before applying the drops to reduce discomfort.
  • Lie down or tilt your head to the side when applying the drops, and keep the ear facing upward for a few minutes after administration.
  • Avoid touching the dropper to any surfaces, including your ear, to prevent contamination.
  • Complete the full course of treatment, even if symptoms improve, to prevent the recurrence of infection.


Side Effects of Cortisporin-TC

Common Side Effects

  • Mild burning or stinging sensation when the drops are applied
  • Temporary ear discomfort
  • Redness or itching at the application site


Uncommon/Severe Side Effects

  • Allergic reactions (rash, itching, swelling, dizziness)
  • Hearing loss or ringing in the ears (rare but serious)


Risks and Warnings of Cortisporin-TC

Perforated Eardrum: Cortisporin-TC should not be used if you have a perforated eardrum, as it could lead to more serious complications or damage to the ear.

Allergic Reactions: Neomycin can cause allergic reactions in some patients. Discontinue use if signs of an allergic reaction occur, such as rash, swelling, or difficulty breathing.

Hearing Loss: Rarely, prolonged use of neomycin-containing ear drops can result in hearing loss. Inform your healthcare provider if you experience any changes in hearing while using this medication.


Interactions with Cortisporin-TC

Common Drug Interactions

Due to its localized application, systemic interactions are rare. However, patients should inform their healthcare provider of all other medications and supplements they are using to avoid potential interactions.



Alternatives to Cortisporin-TC

  • Ciprodex (ciprofloxacin and dexamethasone): A combination antibiotic and corticosteroid used for similar ear infections.
  • Cortisporin Otic (neomycin, polymyxin B, and hydrocortisone): Another option for treating bacterial ear infections and inflammation.
  • Ofloxacin Otic: An antibiotic ear drop used to treat bacterial infections, particularly for those allergic to neomycin.