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Clindamycin Phos-Benzoyl Perox
Clindamycin Phosphate-Benzoyl Peroxide is a combination topical treatment used to manage acne vulgaris. This medication combines clindamycin phosphate, an antibiotic, with benzoyl peroxide, a powerful antimicrobial and keratolytic agent. Clindamycin reduces the amount of acne-causing bacteria, while benzoyl peroxide helps to unclog pores and reduce inflammation. The combination of these two active ingredients makes it highly effective for treating mild to moderate acne, particularly in patients with inflammatory acne lesions like papules and pustules.
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Frequently Asked Questions
How long does it take for Clindamycin Phosphate-Benzoyl Peroxide to work?
It may take several weeks (4-8 weeks) to see noticeable improvement in acne. It’s important to continue using the medication as prescribed, even if you don’t see immediate results.
Can I use Clindamycin Phosphate-Benzoyl Peroxide with other acne medications?
Consult your healthcare provider before combining this medication with other acne treatments, as using multiple products can increase the risk of skin irritation.
What should I do if I miss a dose?
If you miss a dose, apply it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and continue your regular schedule. Do not double the dose.
Is Clindamycin Phosphate-Benzoyl Peroxide safe during pregnancy?
Consult your healthcare provider if you are pregnant or planning to become pregnant before using this medication.
Can I wear makeup while using Clindamycin Phosphate-Benzoyl Peroxide?
Yes, you can use makeup while using this medication. Be sure to choose non-comedogenic products to avoid clogging your pores.
Comprehensive Drug Guide
How Does Clindamycin Phos-Benzoyl Perox Work?
Clindamycin Phosphate inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit of Propionibacterium acnes, the bacteria responsible for acne. Benzoyl Peroxide works by releasing oxygen into the skin’s pores, which kills acne-causing bacteria and reduces oil production. Additionally, benzoyl peroxide has keratolytic properties, helping to break down the outer layer of skin and prevent clogged pores.
Common Dosages
- Gel or Lotion: 1.2% clindamycin phosphate / 2.5%, 5%, or 3% benzoyl peroxide
Typical Dosing
- For acne: Apply a thin layer to the affected area once or twice daily, as directed by your healthcare provider. Clean the skin with a mild cleanser before application and allow it to dry completely.
Typical Dosing
FDA Approved Indications
- Acne vulgaris (mild to moderate acne)
Who Shouldn't Take Clindamycin Phos-Benzoyl Perox?
- Known hypersensitivity to clindamycin, benzoyl peroxide, or any component of the formulation
- History of regional enteritis, ulcerative colitis, or antibiotic-associated colitis
Advice From The Pharmacist
- Apply a thin layer to clean, dry skin, and avoid contact with the eyes, mouth, and other mucous membranes.
- Benzoyl peroxide may bleach hair, clothing, and bedding, so use caution during application.
- Clindamycin Phosphate-Benzoyl Peroxide may cause skin dryness or irritation, especially during the first few weeks of use. Use a non-comedogenic moisturizer to alleviate dryness.
- It may take several weeks to see noticeable improvements in acne. Continue using the medication as prescribed, even if your symptoms begin to improve.
- Avoid excessive sun exposure while using this product, and apply sunscreen regularly to protect your skin.
Side Effects of Clindamycin Phos-Benzoyl Perox
Common Side Effects
- Dryness or peeling of the skin
- Redness or irritation at the application site
- Itching or stinging sensation
- Skin sensitivity to sunlight
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, swelling, difficulty breathing)
- Diarrhea or colitis (due to systemic absorption of clindamycin)
Risks and Warnings of Clindamycin Phos-Benzoyl Perox
- Photosensitivity: Benzoyl peroxide can increase your skin's sensitivity to sunlight, making it easier to get sunburned. Use sunscreen and wear protective clothing when exposed to sunlight.
- Diarrhea and Colitis: While rare, topical clindamycin can be absorbed systemically, causing diarrhea or colitis. If you experience severe abdominal pain or bloody stools, discontinue use and consult your healthcare provider.
- Skin Irritation: Some users may experience irritation or redness at the application site. If irritation becomes severe, stop using the product and contact your healthcare provider.
Interactions with Clindamycin Phos-Benzoyl Perox
Common Drug Interactions
- Topical Retinoids: Using clindamycin phosphate-benzoyl peroxide with other acne treatments, such as retinoids, may increase skin irritation. Consult your healthcare provider before combining treatments.
- Oral Clindamycin: Avoid combining topical clindamycin with oral clindamycin, as this may increase the risk of systemic side effects, including diarrhea and colitis.
Alternatives to Clindamycin Phos-Benzoyl Perox
- Adapalene-Benzoyl Peroxide (Epiduo): A combination of a retinoid and benzoyl peroxide used to treat acne.
- Benzoyl Peroxide Monotherapy: A standalone treatment for acne that works to kill bacteria and clear pores.
- Topical Retinoids (Tretinoin): Used to treat acne by promoting skin cell turnover and preventing clogged pores.
- Oral Antibiotics (Doxycycline): Used for moderate to severe acne when topical treatments are not sufficient.
