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Ciprofloxacin-Dexamethasone
Ciprofloxacin-Dexamethasone is a combination medication used to treat acute otitis media in patients with ear tubes and acute otitis externa (swimmer’s ear). It combines ciprofloxacin, a fluoroquinolone antibiotic, and dexamethasone, a corticosteroid. Ciprofloxacin works by eliminating the bacterial infection, while dexamethasone reduces inflammation, redness, and discomfort in the ear. This combination is commonly prescribed to treat bacterial infections of the outer and middle ear, helping both to eliminate the infection and alleviate symptoms. It is typically available in otic (ear drops) form.
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Frequently Asked Questions
How long does it take for Ciprofloxacin-Dexamethasone to work?
Most patients begin to notice improvement in symptoms within 2 to 3 days of starting treatment, but it is important to complete the full 7-day course to ensure the infection is completely eradicated.
Can Ciprofloxacin-Dexamethasone be used for viral or fungal ear infections?
No, Ciprofloxacin-Dexamethasone is effective only against bacterial infections. It will not work for viral or fungal infections. Your doctor will prescribe an appropriate treatment if you have a different type of infection.
What should I do if I miss a dose?
If you miss a dose, apply it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and resume your normal dosing schedule. Do not double the dose.
Can I swim while using Ciprofloxacin-Dexamethasone?
It is best to avoid swimming or getting water in the affected ear while using Ciprofloxacin-Dexamethasone to prevent additional irritation or prolonging the infection.
Is Ciprofloxacin-Dexamethasone safe for children?
Yes, Ciprofloxacin-Dexamethasone is safe for children aged 6 months and older, but always follow your healthcare provider’s dosing instructions carefully.
Comprehensive Drug Guide
How Does Ciprofloxacin-Dexamethasone Work?
Ciprofloxacin, the antibiotic component, works by inhibiting bacterial enzymes called DNA gyrase and topoisomerase IV, which are essential for bacterial DNA replication, transcription, and repair. By stopping these processes, Ciprofloxacin kills the bacteria causing the infection. Dexamethasone, a corticosteroid, reduces inflammation by suppressing the immune response, leading to a decrease in swelling, redness, and pain in the ear.
Common Dosages
- Otic Suspension: Each mL contains 0.3% ciprofloxacin and 0.1% dexamethasone.
Typical Dosing
- For acute otitis media: Instill 4 drops into the affected ear twice daily for 7 days.
- For acute otitis externa (swimmer’s ear): Instill 4 drops into the affected ear twice daily for 7 days. Always follow the specific instructions given by your healthcare provider.
Typical Dosing
FDA Approved Indications
- Acute otitis media with ear tubes
- Acute otitis externa (swimmer’s ear) caused by susceptible bacteria
Who Shouldn't Take Ciprofloxacin-Dexamethasone?
- Hypersensitivity to ciprofloxacin, dexamethasone, or other quinolones
- Viral or fungal ear infections
- Perforated eardrum (unless otherwise directed by a healthcare provider)
Advice From The Pharmacist
- Warm the bottle in your hands before administering to avoid dizziness caused by cold drops.
- Lie down or tilt your head with the affected ear facing upward. Remain in this position for a few minutes after administering the drops to ensure they are fully absorbed.
- Avoid getting water into the affected ear while using Ciprofloxacin-Dexamethasone. You may want to use earplugs or other protective measures when showering or swimming.
- Complete the entire course of treatment, even if symptoms improve, to prevent the return of the infection or bacterial resistance.
- If you are using other ear medications, consult your healthcare provider about how to schedule the doses to avoid interference.
Side Effects of Ciprofloxacin-Dexamethasone
Common Side Effects
- Mild discomfort or itching in the ear
- Temporary stinging or burning sensation after application
- Feeling of fullness in the ear
- Ear residue
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, swelling, difficulty breathing)
- Worsening ear pain or hearing changes
- Dizziness or lightheadedness
Risks and Warnings of Ciprofloxacin-Dexamethasone
- Allergic Reactions: Patients allergic to quinolones or corticosteroids should avoid using Ciprofloxacin-Dexamethasone. Discontinue use and seek medical attention if an allergic reaction occurs.
- Superinfection: Prolonged use may lead to secondary infections such as fungal or viral ear infections. Consult your doctor if your symptoms worsen or do not improve after the full course of treatment.
- Perforated Eardrum: Ciprofloxacin-Dexamethasone should not be used if you have a perforated eardrum unless otherwise directed by your healthcare provider.
Interactions with Ciprofloxacin-Dexamethasone
Common Drug Interactions
Since Ciprofloxacin-Dexamethasone is applied topically in the ear, systemic drug interactions are unlikely. However, you should inform your doctor about all medications, supplements, and herbal products you are using to avoid any potential conflicts.
Alternatives to Ciprofloxacin-Dexamethasone
- Ofloxacin (Floxin Otic): A fluoroquinolone antibiotic used to treat bacterial ear infections.
- Ciprofloxacin Otic Solution: An antibiotic-only formulation for treating bacterial ear infections.
- Polymyxin B-neomycin-hydrocortisone (Cortisporin Otic): Another combination antibiotic and corticosteroid formulation for treating ear infections and inflammation.
