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Cibinqo
Cibinqo (generic name: abrocitinib) is an oral medication used to treat moderate to severe atopic dermatitis (eczema) in adults and adolescents who are candidates for systemic therapy. Cibinqo belongs to a class of medications known as Janus kinase (JAK) inhibitors, which help reduce inflammation associated with eczema. It works by targeting the JAK1 enzyme, which plays a role in the inflammatory process. This medication is intended for individuals whose atopic dermatitis is not adequately controlled by topical treatments or other therapies.
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Frequently Asked Questions
How long does it take for Cibinqo to start working?
Some patients may notice improvements in their atopic dermatitis symptoms within 2 to 4 weeks, but full effects may take longer.
Can I take Cibinqo with food?
Yes, Cibinqo can be taken with or without food.
Do I need regular blood tests while taking Cibinqo?
Yes, periodic blood tests are recommended to monitor for liver function, blood cell counts, and cholesterol levels while taking Cibinqo.
Can I receive vaccines while taking Cibinqo?
Avoid live vaccines while taking Cibinqo. Non-live vaccines may still be administered, but consult your healthcare provider for guidance.
What should I do if I experience signs of infection while taking Cibinqo?
If you experience symptoms such as fever, chills, persistent cough, or shortness of breath, contact your healthcare provider immediately, as these may be signs of a serious infection.
Can I take Cibinqo if I’m pregnant or breastfeeding?
Cibinqo may not be safe during pregnancy or breastfeeding. Consult your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding.
Is Cibinqo a steroid?
No, Cibinqo is not a steroid. It is a JAK inhibitor that reduces inflammation by targeting the JAK1 enzyme, which plays a role in immune signaling.
Can I take Cibinqo if I have a history of blood clots?
Cibinqo may increase the risk of blood clots. If you have a history of blood clots or other clotting disorders, discuss this with your healthcare provider before starting Cibinqo.
How long will I need to take Cibinqo for atopic dermatitis?
The duration of treatment with Cibinqo depends on your response to the medication. Some patients may require long-term treatment to manage their symptoms.
Can Cibinqo cure eczema?
Cibinqo is not a cure for eczema, but it can help manage and reduce symptoms of moderate to severe atopic dermatitis.
Comprehensive Drug Guide
How Does Cibinqo Work?
Cibinqo works by inhibiting the JAK1 enzyme, which is involved in the inflammatory processes seen in atopic dermatitis. By blocking this enzyme, Cibinqo helps reduce the immune system's overreaction that leads to skin inflammation, redness, and itching associated with eczema.
Common Dosages
- Starting dose: 100 mg once daily.
- Higher dose: For patients who do not respond adequately to the initial dose, the dose can be increased to 200 mg once daily.
For patients with certain health conditions (e.g., liver or kidney impairment), a 50 mg dose may be recommended.
Typical Dosing
- Administration: Cibinqo is taken orally, once daily, with or without food. Swallow the tablet whole with water, and do not crush or split it.
- Frequency: Taken once daily at the same time each day.
- Duration of Use: The treatment duration depends on the patient’s response. Cibinqo is typically used for long-term management of atopic dermatitis, as prescribed by a healthcare provider.
Typical Dosing
FDA Approved Indications
Moderate to severe atopic dermatitis (eczema) in adults and adolescents aged 12 and older who require systemic therapy when topical treatments have not been effective.
Who Shouldn't Take Cibinqo?
- Hypersensitivity to abrocitinib or any of its ingredients.
- Active serious infections, such as tuberculosis, as Cibinqo can suppress the immune system, making infections more likely or severe.
- Severe liver impairment.
- Patients with an increased risk of developing blood clots should consult with their healthcare provider before use.
Advice From The Pharmacist
- Be aware of the potential risk of serious infections, such as pneumonia or tuberculosis. Get tested for latent tuberculosis before starting treatment.
- Monitor for signs of infection, such as fever, chills, and persistent cough, and contact their healthcare provider immediately if any symptoms of infection develop.
- Avoid live vaccines while on Cibinqo, as the medication may suppress the immune system.
- Report any unusual bruising, bleeding, or signs of blood clots, such as swelling or pain in the legs, chest pain, or shortness of breath.
- Inform their healthcare provider if they are pregnant or planning to become pregnant, as Cibinqo may not be safe during pregnancy.
Side Effects of Cibinqo
Common Side Effects
- Nausea
- Headache
- Abdominal pain
- Upper respiratory tract infections
- Acne
Uncommon/Severe Side Effects
- Increased risk of serious infections, including tuberculosis, shingles (herpes zoster), and bacterial infections.
- Blood clots (deep vein thrombosis or pulmonary embolism).
- Low blood cell counts (anemia, neutropenia, or thrombocytopenia).
- Increased cholesterol levels.
- Liver enzyme elevations: Liver function tests should be monitored periodically.
Risks and Warnings of Cibinqo
- Serious Infections: Cibinqo can increase the risk of serious infections, including tuberculosis, bacterial infections, and viral infections. Patients should be screened for tuberculosis and monitored for infections throughout treatment.
- Blood Clots: Cibinqo may increase the risk of developing blood clots (deep vein thrombosis and pulmonary embolism). Patients with a history of blood clots or at high risk for clotting disorders should use this medication with caution.
- Cancer Risk: There is a potential increased risk of cancers, such as skin cancer and lymphoma, with long-term use of JAK inhibitors like Cibinqo. Regular skin checks and monitoring are recommended.
- Liver Function: Liver enzyme levels may rise while taking Cibinqo. Regular monitoring of liver function tests is recommended.
- Low Blood Cell Counts: Cibinqo can lower white blood cell counts, which may increase the risk of infections. Periodic blood tests should be conducted to monitor for abnormalities.
Interactions with Cibinqo
Common Drug Interactions
- Strong CYP3A4 inhibitors: Such as ketoconazole or clarithromycin, which may increase the levels of Cibinqo in the body and increase the risk of side effects.
- Strong CYP3A4 inducers: Such as rifampin, which may decrease the effectiveness of Cibinqo.
- Immunosuppressants: Using other immunosuppressive drugs like methotrexate or cyclosporine alongside Cibinqo can increase the risk of infections.
- Live vaccines: Avoid receiving live vaccines during Cibinqo treatment.
Alternatives to Cibinqo
- Topical corticosteroids: Such as hydrocortisone or betamethasone.
- Topical calcineurin inhibitors: Such as tacrolimus and pimecrolimus.
- Dupilumab (Dupixent): An injectable biologic therapy for atopic dermatitis.
- Other systemic immunosuppressants: Such as cyclosporine or methotrexate, which may be used for severe eczema when topical treatments are not effective.