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Catapres-TTS-3
Catapres-TTS-3 is a transdermal patch containing clonidine, an alpha-2 adrenergic agonist used to treat high blood pressure (hypertension). Clonidine works by decreasing sympathetic nervous system activity, which results in the relaxation of blood vessels and lowering of heart rate, effectively reducing blood pressure. The patch provides a consistent release of clonidine over 7 days, making it an effective option for continuous blood pressure management.
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Frequently Asked Questions
How long does it take for Catapres-TTS-3 to start working?
Catapres-TTS-3 typically begins to lower blood pressure within a few hours after applying the patch. However, full effects may take a few days, and blood pressure will be controlled continuously for 7 days.
Can I shower or swim while wearing the patch?
Yes, Catapres-TTS-3 is designed to remain in place during bathing, showering, or swimming. However, it’s important to check that the patch stays securely attached.
What should I do if the patch falls off?
If the patch falls off, apply a new one to a different area of skin and continue with your regular 7-day schedule.
Can I stop using Catapres-TTS-3 suddenly?
No, stopping Catapres-TTS-3 abruptly can lead to a dangerous increase in blood pressure (rebound hypertension). It is essential to taper the dose gradually under medical supervision if discontinuation is necessary.
Does Catapres-TTS-3 cause drowsiness?
Yes, drowsiness is a common side effect. Patients should avoid driving or operating heavy machinery until they know how the medication affects them.
Can Catapres-TTS-3 be used during pregnancy?
Clonidine should only be used during pregnancy if clearly needed and prescribed by a healthcare provider. Discuss the risks and benefits with your doctor before using the medication during pregnancy.
How should I store Catapres-TTS-3?
Store Catapres-TTS-3 patches at room temperature, away from heat and moisture. Keep them out of reach of children, and dispose of used patches safely.
Comprehensive Drug Guide
How Does Catapres-TTS-3 Work?
Catapres-TTS-3 works by stimulating alpha-2 adrenergic receptors in the brain. This decreases the release of certain neurotransmitters that control heart rate and blood vessel tension, leading to:
- Vasodilation: Relaxation of blood vessels, which lowers blood pressure.
- Decreased Heart Rate: Reduction in heart rate as a result of lower sympathetic stimulation.
What is Catapres-TTS-3 Used For?
Hypertension (High Blood Pressure): Used to lower blood pressure either as a standalone treatment or in combination with other antihypertensive medications.
Common Dosages
Catapres-TTS-3 is available by prescription only and is not classified as a controlled substance. It delivers 0.3 mg of clonidine per day over a 7-day period.
Other available strengths include:
- Catapres-TTS-1: Delivers 0.1 mg of clonidine per day.
- Catapres-TTS-2: Delivers 0.2 mg of clonidine per day.
Administration: The patch is applied to a clean, dry, and hairless area of the skin, typically on the upper arm or chest. The patch is worn for 7 days, after which it is replaced with a new patch. Rotate the application site each week to avoid skin irritation.
Frequency: Apply one patch every 7 days.
Duration of Use: Catapres-TTS-3 is used for long-term management of hypertension. Regular monitoring of blood pressure is necessary to ensure its effectiveness.
Typical Dosing
FDA Approved Indications
The dosage for Catapres-TTS-3 is:
- 0.3 mg per day (via transdermal patch), applied once every 7 days.
Off-Label Uses
Who Shouldn't Take Catapres-TTS-3?
Catapres-TTS-3 is contraindicated in patients with:
- Hypersensitivity to clonidine or any of the patch's components.
- Severe bradycardia (slow heart rate) or conditions where a further reduction in heart rate could be harmful.
Advice From The Pharmacist
Patients using Catapres-TTS-3 should be advised to:
- Ensure proper application of the patch, rotating the application site each week to prevent skin irritation.
- Replace the patch every 7 days at the same time each week and verify that the patch remains securely attached.
- Avoid abruptly discontinuing the patch, as this may lead to a rapid increase in blood pressure (rebound hypertension). If the patch needs to be discontinued, it should be tapered off gradually under medical supervision.
- Be aware of side effects such as dizziness or drowsiness, particularly when starting treatment, as clonidine can cause sedation and hypotension.
- Avoid using alcohol or sedatives, as these can increase the drowsiness associated with clonidine.
Side Effects of Catapres-TTS-3
Common Side Effects
- Drowsiness or fatigue
- Dry mouth
- Dizziness or lightheadedness, particularly when standing up (orthostatic hypotension)
- Skin irritation or redness at the patch site
Uncommon/Severe Side Effects
- Severe Bradycardia (Slow Heart Rate): Symptoms include dizziness, fainting, or extreme fatigue.
- Rebound Hypertension: If the patch is stopped abruptly, blood pressure may rise sharply.
- Severe Skin Reactions: Such as rash, itching, or infection at the patch site.
Risks and Warnings of Catapres-TTS-3
Rebound Hypertension: Stopping Catapres-TTS-3 suddenly can cause a dangerous spike in blood pressure. If the patch needs to be discontinued, the dose should be tapered off gradually under medical supervision.
Sedation and Drowsiness: Clonidine can cause drowsiness, especially during the initial phase of treatment. Patients should avoid driving or operating machinery until they know how the medication affects them.
Hypotension and Bradycardia: Clonidine can cause a significant drop in blood pressure and slow heart rate. Patients should be monitored for signs of hypotension and bradycardia, particularly when initiating therapy or increasing the dose.
Interactions with Catapres-TTS-3
Common Drug Interactions
Catapres-TTS-3 may interact with other medications, including:
- Antihypertensive Medications: Combining clonidine with other medications that lower blood pressure (e.g., beta-blockers, diuretics) can increase the risk of hypotension and bradycardia.
- Sedatives and Alcohol: These can increase the sedative effects of clonidine, causing excessive drowsiness.
- Tricyclic Antidepressants: May reduce the blood pressure-lowering effects of clonidine.
Patients should inform their healthcare provider of all medications and supplements they are taking to avoid potential interactions.
Alternatives to Catapres-TTS-3
Alternative treatments for hypertension include:
- Other Alpha-2 Adrenergic Agonists: Such as guanfacine, which has similar effects to clonidine.
- Beta-Blockers: Such as metoprolol or atenolol, which lower blood pressure by reducing heart rate.
- ACE Inhibitors: Such as lisinopril or enalapril, which reduce blood pressure by relaxing blood vessels.
- Angiotensin II Receptor Blockers (ARBs): Such as losartan or valsartan, used for blood pressure control.
- Calcium Channel Blockers: Such as amlodipine, which help relax blood vessels to lower blood pressure.
