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Catapres-TTS-2
Catapres-TTS-2 is a transdermal patch that delivers clonidine, an alpha-2 adrenergic agonist used to manage high blood pressure (hypertension). Clonidine works by stimulating receptors in the brain that reduce heart rate and relax blood vessels, thereby lowering blood pressure. The patch releases a controlled amount of clonidine over a 7-day period, providing a convenient option for patients who require continuous blood pressure control.
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Frequently Asked Questions
How long does it take for Catapres-TTS-2 to start working?
The patch typically starts lowering blood pressure within a few hours of application. Full effects may take a few days, and blood pressure will continue to be controlled throughout the 7 days the patch is worn.
Can I shower or swim while wearing the patch?
Yes, the Catapres-TTS-2 patch is designed to stay in place during bathing, showering, or swimming. However, it’s important to regularly check to ensure the patch remains securely attached.
What should I do if the patch falls off?
If the patch falls off, apply a new one to a different area of skin and continue with your normal 7-day schedule.
Can I stop using Catapres-TTS-2 suddenly?
No, stopping Catapres-TTS-2 suddenly can cause a dangerous spike in blood pressure (rebound hypertension). If discontinuation is necessary, your healthcare provider will advise you on how to taper the dose gradually.
Does Catapres-TTS-2 cause drowsiness?
Yes, drowsiness is a common side effect, especially when first starting treatment. Patients should avoid driving or operating heavy machinery until they know how the medication affects them.
Can Catapres-TTS-2 be used during pregnancy?
Clonidine should only be used during pregnancy if clearly needed and prescribed by a healthcare provider. Discuss the risks and benefits with your doctor before using the medication during pregnancy.
How should I store Catapres-TTS-2?
Store Catapres-TTS-2 patches at room temperature, away from heat and moisture. Keep them out of reach of children and dispose of used patches safely.
Comprehensive Drug Guide
How Does Catapres-TTS-2 Work?
Catapres-TTS-2 works by activating alpha-2 adrenergic receptors in the brain, reducing the release of certain neurotransmitters involved in regulating blood pressure. This lowers the sympathetic nervous system activity, leading to:
- Vasodilation: Relaxation of blood vessels, which reduces resistance and lowers blood pressure.
- Decreased Heart Rate: Reduces the heart rate by decreasing sympathetic stimulation.
What is Catapres-TTS-2 Used For?
Hypertension (High Blood Pressure): Used to lower blood pressure, either as monotherapy or in combination with other antihypertensive medications.
Common Dosages
Catapres-TTS-2 is available by prescription only and is not classified as a controlled substance. It comes in a transdermal patch that delivers 0.2 mg of clonidine per day for 7 days.
Administration: The patch should be applied to a clean, dry, and hairless area of the skin, such as the upper arm or chest. It should be worn continuously for 7 days. Rotate the application site each time you apply a new patch to prevent skin irritation.
Frequency: The patch is replaced every 7 days.
Duration of Use: Catapres-TTS-2 is used long-term for managing hypertension, and regular blood pressure monitoring is necessary to assess effectiveness.
Typical Dosing
FDA Approved Indications
The typical dosage for Catapres-TTS-2 is:
- Catapres-TTS-2 patch delivers 0.2 mg of clonidine per day. The patch is applied once every 7 days.
Off-Label Uses
It's also been used to manage withdrawal symptoms from opioids, as part of a smoking cessation plan, and hot sweats
- The dose is decided by the healthcare provider based on individual conditions.
Who Shouldn't Take Catapres-TTS-2?
Catapres-TTS-2 is contraindicated in patients with:
- Hypersensitivity to clonidine or any components of the patch.
- Severe bradycardia (slow heart rate) or conditions where a further reduction in heart rate could be dangerous.
Advice From The Pharmacist
Patients using Catapres-TTS-2 should be advised to:
- Ensure proper application of the patch, rotating the application site weekly to prevent skin irritation.
- Replace the patch every 7 days at the same time and check that the patch remains securely in place.
- Avoid abruptly discontinuing the patch, as this can lead to a rapid increase in blood pressure (rebound hypertension). If the patch needs to be stopped, it should be tapered off under medical supervision.
- Be cautious about side effects like dizziness or drowsiness, especially when starting therapy, as clonidine can cause sedation and hypotension.
- Avoid using alcohol or sedative medications, as these may enhance the drowsiness caused by clonidine.
Side Effects of Catapres-TTS-2
Common Side Effects
- Drowsiness or fatigue
- Dry mouth
- Dizziness or lightheadedness (particularly when standing)
- Skin irritation or redness at the patch site
Uncommon/Severe Side Effects
- Severe Bradycardia (Slow Heart Rate): Symptoms include fainting, dizziness, or extreme fatigue.
- Rebound Hypertension: If the patch is discontinued abruptly, blood pressure may rise significantly.
- Severe Skin Reactions: Such as rash, itching, or infection at the site of application.
Risks and Warnings of Catapres-TTS-2
Rebound Hypertension: Abrupt discontinuation of clonidine can cause a dangerous spike in blood pressure. If the patch needs to be stopped, it should be done gradually under medical supervision.
Sedation and Drowsiness: Clonidine can cause drowsiness, especially when starting treatment or increasing the dose. Patients should avoid activities requiring full alertness, such as driving, until they know how the medication affects them.
Hypotension and Bradycardia: Clonidine can cause a significant reduction in blood pressure and heart rate. Patients should be monitored for signs of hypotension and bradycardia, especially during the initial phase of treatment.
Interactions with Catapres-TTS-2
Common Drug Interactions
Catapres-TTS-2 may interact with other medications, including:
- Antihypertensive Medications: Combining clonidine with other blood pressure-lowering drugs (e.g., beta-blockers or diuretics) can increase the risk of low blood pressure and slow heart rate.
- Sedatives and Alcohol: These can increase the sedative effects of clonidine, leading to excessive drowsiness.
- Tricyclic Antidepressants: These may reduce the effectiveness of clonidine in controlling blood pressure.
Patients should inform their healthcare provider of all medications and supplements they are taking to avoid potential interactions.
Alternatives to Catapres-TTS-2
Alternative treatments for hypertension include:
- Other Alpha-2 Adrenergic Agonists: Such as guanfacine, which works similarly to clonidine.
- Beta-Blockers: Such as atenolol or metoprolol, which lower blood pressure by reducing heart rate.
- ACE Inhibitors: Such as lisinopril or enalapril, used to lower blood pressure by relaxing blood vessels.
- ARBs (Angiotensin II Receptor Blockers): Such as losartan or valsartan, used for hypertension management.
- Calcium Channel Blockers: Such as amlodipine, which help relax blood vessels to lower blood pressure.
