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Cambia
Cambia is a prescription nonsteroidal anti-inflammatory drug (NSAID) that contains diclofenac potassium. It is specifically formulated as an oral solution to treat acute migraine attacks in adults. Cambia works by reducing substances in the body that cause pain and inflammation, making it particularly useful for the treatment of moderate to severe migraines. It is not intended for the prevention of migraines or for treating other types of pain.
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Frequently Asked Questions
Can Candesartan cause weight gain?
Weight gain is not a common side effect of Candesartan. However, in rare cases, it may cause fluid retention, particularly in people with heart failure. If you experience significant or unexplained weight gain, especially if it's accompanied by swelling in the legs or abdomen, contact your healthcare provider.
Can I drink alcohol while taking Candesartan?
While moderate alcohol consumption is generally safe, alcohol can lower blood pressure and increase the risk of dizziness or fainting, especially when combined with Candesartan. It's best to limit alcohol intake and consult your healthcare provider for specific advice.
Can I take Candesartan if I have kidney disease?
Candesartan may be used in patients with kidney disease, but it requires careful monitoring of kidney function and potassium levels. In some cases, dosage adjustments may be necessary, and the medication may need to be discontinued if kidney function worsens.
Can I take Candesartan if I have kidney disease?
Candesartan may be used in patients with kidney disease, but it requires careful monitoring of kidney function and potassium levels. In some cases, dosage adjustments may be necessary, and the medication may need to be discontinued if kidney function worsens.
Is Candesartan the same as an ACE inhibitor?
No, Candesartan is an angiotensin II receptor blocker (ARB), while ACE inhibitors work by blocking the enzyme that converts angiotensin I to angiotensin II. Both ARBs and ACE inhibitors lower blood pressure and treat heart failure, but they act through different mechanisms. Candesartan is often used in patients who cannot tolerate ACE inhibitors due to side effects like coughing.
Can I take other blood pressure medications with Candesartan?
Yes, Candesartan is often combined with other blood pressure medications, such as diuretics, beta-blockers, or calcium channel blockers, to achieve better blood pressure control. However, these combinations should be managed by a healthcare provider to avoid adverse effects like low blood pressure or high potassium levels.
Comprehensive Drug Guide
How Does Cambia Work?
Diclofenac works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins—substances in the body that cause inflammation, pain, and fever. By blocking COX-1 and COX-2 enzymes, Cambia reduces the production of prostaglandins, thereby alleviating migraine symptoms such as headache, nausea, and sensitivity to light and sound.
What is Cambia Used For?
Acute Treatment of Migraine Attacks: In adults with or without aura.
Common Dosages
Cambia is available by prescription only and is provided as a powder that is dissolved in water and taken orally.
Administration: Cambia is taken as a single dose at the onset of a migraine. Dissolve the contents of one packet in a small amount of water and drink immediately. Do not mix it with any other liquids or foods, and do not chew or swallow the powder without mixing it with water.
Duration of Use: Cambia is intended for occasional use during migraine attacks. It should not be used for chronic daily headaches or as a preventive medication for migraines.
Typical Dosing
FDA Approved Indications
The typical dosage of Cambia is:
- 50 mg packet: One packet dissolved in 1 to 2 ounces (30 to 60 mL) of water and taken orally at the onset of a migraine attack. It should be taken immediately after mixing, and no more than one packet should be used per migraine episode.
Who Shouldn't Take Cambia?
Cambia is contraindicated in patients with:
- A history of asthma, urticaria, or other allergic-type reactions after taking NSAIDs or aspirin.
- Active or history of gastrointestinal bleeding or ulcers.
- Severe liver or kidney impairment.
- Coronary artery bypass graft (CABG) surgery.
- Known hypersensitivity to diclofenac or any other NSAIDs.
Advice From The Pharmacist
Patients using Cambia should be advised to:
- Take the medication at the first sign of a migraine to maximize its effectiveness. Delaying treatment may reduce its efficacy.
- Avoid using other NSAIDs or aspirin while taking Cambia, as this can increase the risk of side effects such as gastrointestinal bleeding or kidney damage.
- Be aware that Cambia does not prevent migraines or reduce their frequency; it is for the acute treatment of an active migraine.
- Contact their healthcare provider if they experience symptoms such as stomach pain, black or tarry stools, or vomiting blood, as these could indicate gastrointestinal bleeding.
- Avoid taking Cambia on an empty stomach to reduce the risk of stomach upset.
- Drink plenty of water to stay hydrated, as dehydration can worsen migraine symptoms.
Side Effects of Cambia
Common Side Effects
- Nausea
- Indigestion or stomach pain
- Diarrhea
- Dizziness or headache (other than migraine)
- Drowsiness
Uncommon/Severe Side Effects
- Gastrointestinal Bleeding: Symptoms include black, tarry stools, vomiting blood, or severe stomach pain.
- Heart Attack or Stroke: Particularly with long-term use or in patients with cardiovascular risk factors.
- Liver Toxicity: Symptoms include yellowing of the skin or eyes (jaundice), dark urine, and severe fatigue.
- Kidney Damage: Decreased urine output, swelling, or shortness of breath.
- Severe Allergic Reactions: Such as rash, itching, swelling, or difficulty breathing.
Risks and Warnings of Cambia
Cardiovascular Risk: Cambia may increase the risk of serious cardiovascular thrombotic events, including heart attack and stroke. This risk may be higher in patients with pre-existing heart conditions or with prolonged use.
Gastrointestinal Risk: NSAIDs like Cambia can cause serious gastrointestinal adverse events, including bleeding, ulcers, and perforation of the stomach or intestines. These events can occur at any time during use
