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Byooviz
Byooviz (ranibizumab-nuna) is a biosimilar to Lucentis (ranibizumab) used to treat several eye conditions related to abnormal blood vessel growth. It is primarily prescribed for neovascular (wet) age-related macular degeneration (AMD), diabetic macular edema (DME), retinal vein occlusion, and other conditions that lead to vision loss due to abnormal blood vessels in the retina.
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Frequently Asked Questions
How long does it take for Byooviz to work?
Some patients notice improvements in their vision within one month, but the full benefits may take several injections.
How often will I need injections?
Byooviz is usually administered once a month, though the frequency may be adjusted based on how well your eye condition responds to the treatment.
Can I drive after receiving Byooviz?
Since the injection may cause blurred vision temporarily, it’s advisable to have someone drive you home after the procedure.
What should I do if I experience pain or swelling after the injection?
Contact your doctor immediately if you experience eye pain, severe redness, or blurred vision, as these could be signs of a serious side effect.
Is Byooviz safe for long-term use?
Yes, Byooviz has been shown to be safe for long-term use in treating retinal conditions, but regular monitoring by your healthcare provider is essential.
Comprehensive Drug Guide
How Does Byooviz Work?
Byooviz works by inhibiting VEGF-A, a protein responsible for the growth of abnormal blood vessels in the retina. By blocking VEGF-A, it reduces the leakage, swelling, and abnormal blood vessel formation that can lead to vision loss in conditions like wet AMD.
Common Dosages
- Intravitreal injection: 0.5 mg/0.05 mL.
Typical Dosing
- The typical dosing is once monthly via intravitreal injection. Based on the patient's response, the dosing interval may be extended.
Typical Dosing
FDA Approved Indications
- Neovascular (wet) age-related macular degeneration (AMD)
- Diabetic macular edema (DME)
- Macular edema following retinal vein occlusion (RVO)
- Myopic choroidal neovascularization (mCNV)
Who Shouldn't Take Byooviz?
- Ocular or periocular infections
- Active intraocular inflammation
- Known hypersensitivity to ranibizumab or any component of the formulation.
Advice From The Pharmacist
- The injection is administered by an ophthalmologist in a clinical setting.
- Avoid rubbing your eye after the injection, and follow all aftercare instructions provided by your doctor.
- Notify your doctor if you experience pain, redness, or blurred vision after the injection.
Side Effects of Byooviz
Common Side Effects
- Eye pain
- Increased intraocular pressure
- Blurred vision
- Conjunctival hemorrhage
Uncommon/Severe Side Effects
- Endophthalmitis (serious eye infection)
- Retinal detachment
Risks and Warnings of Byooviz
- Serious infections: In rare cases, intravitreal injections may cause infections like endophthalmitis. Seek immediate medical attention if symptoms like severe eye pain or redness occur.
- Increased intraocular pressure: Byooviz can temporarily increase eye pressure after injection, so your ophthalmologist will monitor your eye pressure during follow-up visits.
Interactions with Byooviz
Common Drug Interactions
- There are no known significant drug interactions with Byooviz due to its localized administration in the eye.
Alternatives to Byooviz
- Lucentis (ranibizumab): The reference biologic drug to which Byooviz is a biosimilar.
- Eylea (aflibercept): Another anti-VEGF agent used for similar retinal conditions.
- Avastin (bevacizumab): Often used off-label for wet AMD and other eye conditions.
