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Brovana
Brovana (arformoterol tartrate) is a long-acting beta-2 agonist (LABA) used to treat chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. It works by relaxing the muscles in the airways to improve breathing. Brovana is inhaled through a nebulizer and is prescribed to reduce symptoms such as shortness of breath, wheezing, and chronic cough associated with COPD. It is not used for the treatment of acute bronchospasm or asthma.
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Frequently Asked Questions
How long does it take for Brovana to start working?
Brovana starts working within 5 to 10 minutes after administration, but its full effects are usually noticeable within a few doses. It provides 12 hours of symptom relief.
Can I use Brovana for asthma?
No, Brovana is not approved for asthma treatment unless combined with an asthma control medication. Using it alone in asthma patients can increase the risk of asthma-related death
Can Brovana be used with a rescue inhaler?
Yes, Brovana is typically used alongside a rescue inhaler like albuterol for acute breathing problems. Brovana is for maintenance therapy, while the rescue inhaler is used for sudden breathing difficulties.
How should I store Brovana?
Store Brovana vials in the refrigerator. They can be stored at room temperature for up to 6 weeks. Always protect the vials from light and use them immediately after opening.
Can I stop using Brovana if my symptoms improve?
No, continue using Brovana as prescribed, even if your symptoms improve. Stopping the medication abruptly may cause a worsening of symptoms. Always consult your healthcare provider before making changes to your treatment plan.
Comprehensive Drug Guide
How Does Brovana Work?
Brovana works by activating beta-2 adrenergic receptors in the smooth muscle of the airways, causing relaxation and widening of the airways (bronchodilation). This helps to improve airflow and reduce symptoms such as shortness of breath, making it easier to breathe in patients with chronic obstructive pulmonary disease.
Common Dosages
- Nebulizer solution: 15 mcg/2 mL in single-use vials
Typical Dosing
- The usual dose is 15 mcg twice daily, administered using a nebulizer in the morning and evening (about 12 hours apart). Each dose should be inhaled over 5 to 10 minutes.
Typical Dosing
FDA Approved Indications
- Maintenance treatment of COPD, including chronic bronchitis and emphysema.
Who Shouldn't Take Brovana?
- Hypersensitivity to arformoterol, formoterol, or any components of the formulation
- Patients with asthma who are not using a long-term asthma control medication (such as an inhaled corticosteroid), as LABAs can increase the risk of asthma-related death when used alone.
Advice From The Pharmacist
- Use Brovana only with a nebulizer. It is not intended for use with other types of inhalers.
- Do not use Brovana to treat acute bronchospasm (sudden breathing difficulties). Use a rescue inhaler (such as albuterol) for sudden breathing problems.
- Store Brovana vials in the refrigerator, but they can be kept at room temperature for up to 6 weeks if necessary.
- If you miss a dose, skip the missed dose and take the next one at your regular time. Do not double up on doses.
Side Effects of Brovana
Common Side Effects
- Cough
- Throat irritation
- Chest pain
- Leg cramps
Uncommon/Severe Side Effects
- Paradoxical bronchospasm (worsening of breathing immediately after using the medication)
- Increased heart rate or palpitations
- Nervousness or tremors
- Low potassium levels (hypokalemia)
Risks and Warnings of Brovana
- Asthma-related death: LABAs, like Brovana, increase the risk of asthma-related death when used as monotherapy in asthma patients. Brovana is not approved for asthma treatment unless combined with another asthma control medication.
- Cardiovascular effects: Brovana may increase heart rate and blood pressure, which could be problematic in patients with cardiovascular conditions. Monitor your heart health closely while on Brovana.
- Paradoxical bronchospasm: In rare cases, Brovana may cause bronchospasm immediately after use. If this occurs, discontinue use and seek medical attention.
Interactions with Brovana
Common Drug Interactions
- Beta-blockers: These medications may reduce the effectiveness of Brovana and could worsen breathing problems.
- Diuretics: The combination of Brovana and diuretics may increase the risk of low potassium levels (hypokalemia), which can lead to muscle cramps or heart rhythm issues.
- MAO inhibitors and tricyclic antidepressants: These medications may enhance the cardiovascular effects of Brovana, increasing the risk of heart palpitations and arrhythmias.
Alternatives to Brovana
- Perforomist (formoterol): Another long-acting beta-2 agonist used for the maintenance treatment of COPD.
- Serevent (salmeterol): A LABA used for the maintenance treatment of asthma and COPD, often used with inhaled corticosteroids.
- Spiriva (tiotropium): A long-acting muscarinic antagonist (LAMA) used as a maintenance treatment for COPD.
