Bromfenac Sodium (Once-Daily)

The typical dosage of Bromfenac Sodium for postoperative inflammation is:

• Ophthalmic Solution (0.09%): One drop in the affected eye(s) once daily, starting 1 day before surgery and continuing for the first 14 days of the postoperative period.

Bromfenac Sodium is contraindicated in patients with:

• Known hypersensitivity to Bromfenac, other NSAIDs, or any component of the formulation.
• History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs, as this could lead to severe bronchospasm.

Patients using Bromfenac Sodium should be advised to:

• Use the medication exactly as prescribed, and do not exceed the recommended dosage.
• Inform their healthcare provider if they experience any severe side effects, such as persistent eye discomfort, vision changes, or signs of an allergic reaction.
• Avoid wearing contact lenses during the treatment period, particularly if the eye is still inflamed or if instructed by their healthcare provider.
• Be cautious about potential interactions with other medications, especially other NSAIDs, as concurrent use can increase the risk of adverse effects.
• Store the eye drops in a cool, dry place, away from light and moisture.

• Eye irritation or discomfort
• Redness of the eye
• Sensitivity to light
• Blurred vision immediately after application
• Headache

• Corneal Problems: Such as corneal thinning, erosion, or perforation, especially with prolonged use.
• Delayed Healing: NSAIDs like Bromfenac can slow or delay healing of the eye following surgery.
• Allergic Reactions: Such as rash, itching, swelling, or difficulty breathing.

Patients should seek immediate medical attention if they experience severe or persistent side effects.

Corneal Adverse Events: Prolonged use of Bromfenac Sodium may lead to corneal thinning, erosion, or perforation, particularly in patients with underlying corneal conditions. It is important to use the medication only as directed and for the prescribed duration.

Delayed Healing: NSAIDs, including Bromfenac, can delay wound healing, which may affect the recovery process after cataract surgery. Patients should be closely monitored during the treatment period.

Potential for Cross-Sensitivity: Patients who have experienced hypersensitivity reactions to other NSAIDs or aspirin may be at increased risk for similar reactions to Bromfenac.

Bromfenac Sodium may interact with other medications, including:

• Other NSAIDs: Concurrent use of additional NSAIDs may increase the risk of adverse effects such as gastrointestinal or renal toxicity.
• Steroids: When used together with corticosteroids, there may be an increased risk of delayed healing or corneal adverse events.
• Anticoagulants: Although topical use is unlikely to have systemic effects, caution is advised in patients taking anticoagulants due to the theoretical risk of increased bleeding.

Patients should inform their healthcare provider of all medications and supplements they are taking to avoid potential interactions.

Alternative treatments for postoperative inflammation and pain include:

• Other NSAID Eye Drops: Such as ketorolac or nepafenac, which also reduce inflammation and pain after eye surgery.
• Corticosteroid Eye Drops: Such as prednisolone or dexamethasone, which are more potent anti-inflammatory agents but have a different side effect profile.
• Combination Eye Drops: That include both an NSAID and a corticosteroid, depending on the specific needs of the patient.

The choice of treatment depends on the specific condition, the patient’s response to previous treatments, and any underlying medical conditions.