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Briviact
Briviact, with the generic name Brivaracetam, is an anticonvulsant medication used to treat partial-onset seizures in individuals with epilepsy. It is typically used as an adjunctive therapy in patients aged 4 years and older. Briviact is a newer generation anticonvulsant that works by binding to a protein called synaptic vesicle protein 2A (SV2A) in the brain, which is thought to play a role in stabilizing neuronal activity and preventing seizures.
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Frequently Asked Questions
How long does it take for Briviact to start working?
Briviact typically begins to work within a few hours of administration, with the full effect on seizure control observed over several weeks as the dose is adjusted to the optimal level.
Can I stop taking Briviact if my seizures are controlled?
No, you should not stop taking Briviact without consulting your healthcare provider. Abrupt discontinuation can lead to withdrawal seizures and other complications. Any changes to the medication should be done gradually under medical supervision.
Is Briviact safe to use during pregnancy?
The safety of Briviact during pregnancy has not been fully established. Pregnant women or those planning to become pregnant should consult their healthcare provider to discuss the potential risks and benefits before using this medication. It is important to balance the need for seizure control with the potential risks to the fetus.
What should I do if I miss a dose of Briviact?
If you miss a dose, take it as soon as you remember. If it is close to the time of your next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses at once.
Can Briviact cause mood changes?
Yes, mood changes, including irritability, aggression, and depression, are possible side effects of Briviact. Patients should be monitored for any changes in mood or behavior, and any concerning symptoms should be reported to their healthcare provider.
Comprehensive Drug Guide
How Does Briviact Work?
Brivaracetam, the active ingredient in Briviact, works by selectively binding to the SV2A protein in the brain. SV2A is involved in the regulation of neurotransmitter release. By binding to this protein, Brivaracetam helps modulate synaptic transmission and stabilize neuronal activity, which reduces the likelihood of seizures.
What is Briviact Used For?
Treatment of Partial-Onset Seizures: As adjunctive therapy in patients aged 4 years and older with epilepsy.
Common Dosages
Briviact is available by prescription only and is classified as a Schedule V controlled substance in the United States due to its potential for abuse, although this potential is considered low. It is available in several formulations, including oral tablets, oral solution, and an intravenous (IV) injection.
Oral Administration: Briviact can be taken with or without food. The oral tablets should be swallowed whole with water. The oral solution can be measured using a calibrated device to ensure the correct dose.
Intravenous Administration: For patients who cannot take oral medication, Briviact can be administered intravenously. The dosing is the same as for oral administration, and the IV infusion should be given over 2 to 15 minutes.
Typical Dosing
FDA Approved Indications
The typical dosage of Briviact depends on the patient's age, weight, and clinical response:
Adults and Adolescents (16 years and older):
- Starting Dose: 50 mg to 100 mg taken orally twice daily.
- Maintenance Dose: The dose may be adjusted based on efficacy and tolerability, with a usual range of 50 mg to 200 mg twice daily.
Children (4 to 15 years old):
- The dosage is based on body weight and typically starts at 1 mg/kg to 2.5 mg/kg taken twice daily.
Who Shouldn't Take Briviact?
Briviact is contraindicated in patients with:
- Known hypersensitivity to Brivaracetam or any component of the formulation.
Advice From The Pharmacist
Patients using Briviact should be advised to:
- Take the medication exactly as prescribed, and do not skip doses, as doing so can lead to an increased risk of seizures.
- Avoid abrupt discontinuation of Briviact, as it can cause withdrawal seizures. Any discontinuation should be done gradually under medical supervision.
- Inform their healthcare provider of all medications they are taking, including over-the-counter drugs and supplements, to avoid potential interactions.
- Be aware of the potential for side effects such as dizziness, drowsiness, or changes in mood or behavior. Patients should report any unusual symptoms to their healthcare provider.
- Avoid alcohol consumption while taking Briviact, as it may increase the risk of central nervous system side effects, such as dizziness and drowsiness.
- Drowsiness or fatigue
- Dizziness
- Nausea and vomiting
- Irritability or mood changes
- Headache
Side Effects of Briviact
Common Side Effects
- Drowsiness or fatigue
- Dizziness
- Nausea and vomiting
- Irritability or mood changes
- Headache
Uncommon/Severe Side Effects
- Behavioral Changes: Such as aggression, agitation, or depression.
- Suicidal Thoughts and Behaviors: As with other antiepileptic drugs, there is a risk of suicidal thoughts and behaviors. Patients should be monitored for changes in mood or behavior.
- Hypersensitivity Reactions: Such as rash, itching, swelling, or difficulty breathing.
Patients should seek immediate medical attention if they experience severe or persistent side effects.
Risks and Warnings of Briviact
Suicidal Thoughts and Behaviors: Antiepileptic drugs, including Briviact, may increase the risk of suicidal thoughts or behaviors in a small number of patients. Patients and caregivers should be aware of this risk and report any signs of depression, mood changes, or suicidal thoughts to their healthcare provider immediately.
CNS Effects: Briviact can cause central nervous system side effects, including dizziness, drowsiness, and fatigue. Patients should be cautious when driving or operating heavy machinery until they know how the medication affects them.
Drug Interactions: Briviact may interact with other medications, including other antiepileptic drugs, which could affect its efficacy or increase the risk of side effects.
Interactions with Briviact
Common Drug Interactions
Briviact may interact with other medications, including:
- Rifampin: A strong inducer of CYP2C19, which can decrease the levels of Briviact in the blood, potentially reducing its effectiveness.
- Other Antiepileptic Drugs: Such as phenytoin or carbamazepine, which may affect Briviact levels and require dosage adjustments.
- Alcohol: May increase the risk of central nervous system side effects, such as dizziness and drowsiness.
Patients should inform their healthcare provider of all medications and supplements they are taking to avoid potential interactions.
Alternatives to Briviact
Alternative treatments for partial-onset seizures include:
- Other Antiepileptic Drugs (AEDs): Such as levetiracetam, lamotrigine, or oxcarbazepine, which may be used alone or in combination with other medications.
- Combination Therapy: With other AEDs for patients who do not achieve adequate seizure control with monotherapy.
- Surgical Interventions: In some cases, patients with drug-resistant epilepsy may be candidates for surgical procedures to control seizures.
The choice of treatment depends on the specific condition, the patient's response to previous treatments, and any underlying medical conditions.
