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Brisdelle
Brisdelle (paroxetine) is a low-dose selective serotonin reuptake inhibitor (SSRI) used to treat hot flashes associated with menopause. Unlike other SSRIs, Brisdelle is not used for depression but is specifically formulated to alleviate moderate to severe hot flashes in women during menopause.
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Frequently Asked Questions
How long does it take for Brisdelle to start working?
It may take 4 to 8 weeks for Brisdelle to start reducing the frequency and severity of hot flashes.
Can Brisdelle be used with other SSRIs?
No, it is not recommended to use Brisdelle with other SSRIs, as this can increase the risk of serotonin syndrome.
Can Brisdelle be used during pregnancy?
Brisdelle should not be used during pregnancy, as paroxetine has been associated with harm to the fetus.
What should I do if I miss a dose of Brisdelle?
If you miss a dose, take it as soon as you remember. If it is close to your next scheduled dose, skip the missed dose and continue with your regular schedule.
Is Brisdelle safe for long-term use?
Brisdelle is generally safe for long-term use under the supervision of a healthcare provider, though regular monitoring is recommended.
Comprehensive Drug Guide
How Does Brisdelle Work?
Brisdelle works by increasing serotonin levels in the brain, which helps regulate body temperature and reduce the frequency and severity of hot flashes. The exact mechanism by which SSRIs alleviate hot flashes is not fully understood, but it is thought that they affect the brain's temperature regulation centers.
Common Dosages
- Oral capsules: 7.5 mg paroxetine
Typical Dosing
- For hot flashes: The usual dose is one 7.5 mg capsule taken orally at bedtime.
Typical Dosing
FDA Approved Indications
- Moderate to severe vasomotor symptoms (hot flashes) associated with menopause.
Who Shouldn't Take Brisdelle?
- Known hypersensitivity to paroxetine or any component of the formulation.
- Concurrent use of monoamine oxidase inhibitors (MAOIs) or thioridazine.
- Pregnancy, as paroxetine has been associated with fetal harm.
Advice From The Pharmacist
- Take Brisdelle at the same time each day, preferably at bedtime, to help reduce the risk of nausea or drowsiness during the day.
- Do not stop taking Brisdelle abruptly, as this can lead to withdrawal symptoms. Taper off the medication under the guidance of your healthcare provider.
- Brisdelle may take several weeks to start showing full effects, so continue taking the medication as prescribed even if you don’t see immediate results.
Side Effects of Brisdelle
Common Side Effects
- Nausea
- Drowsiness
- Headache
- Dizziness
- Fatigue
Uncommon/Severe Side Effects
- Increased risk of suicidal thoughts or behavior (especially in younger patients)
- Serotonin syndrome (high levels of serotonin that can lead to agitation, confusion, or rapid heart rate)
Risks and Warnings of Brisdelle
- Suicidal Thoughts: Although Brisdelle is a low-dose SSRI, it carries a risk of increasing suicidal thoughts and behavior, particularly in younger patients. Monitor for any changes in mood or behavior.
- Serotonin Syndrome: Brisdelle can increase the risk of serotonin syndrome, especially when used with other serotonergic drugs. Symptoms include agitation, hallucinations, and rapid heartbeat.
Interactions with Brisdelle
Common Drug Interactions
- MAO Inhibitors: Do not use Brisdelle with monoamine oxidase inhibitors (MAOIs) as this can cause dangerous drug interactions.
- NSAIDs and Aspirin: Concurrent use of Brisdelle with NSAIDs or aspirin may increase the risk of bleeding.
- Other SSRIs or SNRIs: Using multiple serotonin-increasing drugs may increase the risk of serotonin syndrome.
Alternatives to Brisdelle
- Gabapentin: A non-hormonal medication used off-label to treat hot flashes.
- Clonidine: A blood pressure medication also used off-label for hot flashes.
- Hormone replacement therapy (HRT): Estrogen and progesterone therapies are commonly used to treat hot flashes, though they are not recommended for all women due to health risks.
