Breztri Aerosphere

The typical dosage of Breztri Aerosphere is:

• Dosage: Two inhalations twice daily (morning and evening), totaling four inhalations per day.

Each inhalation delivers a fixed dose of the three active ingredients.

Breztri Aerosphere is contraindicated in patients with:

• Hypersensitivity to budesonide, glycopyrrolate, formoterol, or any other component of the product.
• Acute episodes of bronchospasm or asthma, as it is not intended for use as a rescue inhaler.

Patients using Breztri Aerosphere should be advised to:

• Use the inhaler exactly as prescribed and not to use it as a rescue inhaler for sudden breathing problems. A separate rescue inhaler (e.g., albuterol) should be used for acute symptoms.
• Rinse their mouth with water and spit it out after each use to reduce the risk of oral thrush (a fungal infection in the mouth).
• Be aware of potential side effects, such as increased heart rate, headache, or dry mouth, and report any severe or persistent side effects to their healthcare provider.
• Store the inhaler at room temperature and protect it from light and moisture. Keep the inhaler clean and dry, and replace it according to the manufacturer's instructions.

• Dry mouth
• Cough
• Sore throat
• Hoarseness
• Headache
• Increased heart rate
• Tremor

• Pneumonia: Increased risk of pneumonia in patients with COPD.
• Paradoxical Bronchospasm: Worsening of breathing immediately after using the inhaler, which requires immediate medical attention.
• Hypokalemia: Low potassium levels, which can cause muscle weakness, cramps, or irregular heartbeats.
• Hyperglycemia: Increased blood sugar levels, particularly in patients with diabetes.

Patients should seek immediate medical attention if they experience signs of serious side effects, such as difficulty breathing, chest pain, or swelling of the face, lips, or tongue.

Increased Risk of Pneumonia: Patients with COPD using inhaled corticosteroids like budesonide may be at an increased risk of developing pneumonia. Patients should be monitored for signs and symptoms of pneumonia, such as fever, chills, and increased sputum production.

Paradoxical Bronchospasm: In rare cases, inhalers can cause paradoxical bronchospasm, where breathing worsens immediately after use. This is a medical emergency and requires immediate discontinuation of the inhaler and treatment with a rescue inhaler.

Cardiovascular Effects: The LABA component (formoterol) can increase heart rate and blood pressure, which may be problematic for patients with cardiovascular conditions. Patients should be monitored for signs of cardiovascular effects.

Breztri Aerosphere may interact with other medications, including:

• Beta-Blockers: Can reduce the effectiveness of formoterol and may worsen breathing problems.
• Diuretics: May increase the risk of low potassium levels (hypokalemia) when used with formoterol.
• MAO Inhibitors or Tricyclic Antidepressants: May increase the risk of cardiovascular side effects when used with formoterol.
• Other Inhaled Medications: Using multiple inhaled medications can increase the risk of side effects and interactions. Patients should inform their healthcare provider of all medications they are taking.

Alternative treatments for COPD include:

• Other Combination Inhalers: Such as Trelegy Ellipta (fluticasone, umeclidinium, and vilanterol) or Anoro Ellipta (umeclidinium and vilanterol), which combine different bronchodilators and corticosteroids.
• Single-Ingredient Inhalers: Such as Spiriva (tiotropium) or Symbicort (budesonide/formoterol), which may be used alone or in combination with other therapies.
• Nebulized Treatments: Such as albuterol or ipratropium, for patients who have difficulty using inhalers.
• Oxygen Therapy: For patients with severe COPD and low oxygen levels.

The choice of treatment depends on the severity of COPD, the patient's response to previous treatments, and overall health status.