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Bonjesta

Bonjesta is a combination of doxylamine succinate and pyridoxine hydrochloride (Vitamin B6) used to treat nausea and vomiting during pregnancy (commonly referred to as morning sickness).



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Frequently Asked Questions

Can I take Bonjesta throughout my entire pregnancy?
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Bonjesta is safe to use throughout pregnancy, but it’s typically used in the first trimester for morning sickness.

Can I stop taking Bonjesta abruptly?
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Consult your healthcare provider before stopping. Gradual reduction may be recommended to avoid a return of symptoms.

Does Bonjesta make you sleepy?
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Yes, drowsiness is a common side effect due to the antihistamine component.

Is Bonjesta safe for my baby?
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Yes, Bonjesta is classified as safe for treating nausea in pregnancy.

How soon will Bonjesta relieve my nausea?
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Relief typically begins within a few hours after the first dose.

Comprehensive Drug Guide

How Does Bonjesta Work?

Doxylamine blocks histamine receptors, reducing nausea, while pyridoxine (Vitamin B6) plays a role in reducing symptoms of nausea during pregnancy.



Common Dosages

  • Bonjesta comes as 20 mg doxylamine and 20 mg pyridoxine extended-release tablets.

Typical Dosing

  • The typical dose is one tablet at bedtime. If nausea persists, a second tablet can be taken in the morning as directed by a healthcare provider.



Typical Dosing

FDA Approved Indications

  • Nausea and vomiting during pregnancy.


Who Shouldn't Take Bonjesta?

  • MAO inhibitors
  • Known hypersensitivity to doxylamine or pyridoxine.


Advice From The Pharmacist

  • Bonjesta may cause drowsiness, so avoid driving or operating machinery until you know how it affects you.
  • Avoid alcohol while using this medication.


Side Effects of Bonjesta

Common Side Effects

  • Drowsiness
  • Dry mouth
  • Dizziness


Uncommon/Severe Side Effects


Risks and Warnings of Bonjesta

  • Sedation: Bonjesta can cause significant drowsiness, so use caution when engaging in activities that require alertness.


Interactions with Bonjesta

Common Drug Interactions

  • CNS depressants (like alcohol) can increase drowsiness.
  • Anticholinergic drugs can enhance Bonjesta's side effects.


Alternatives to Bonjesta

  • Diclegis: Another doxylamine-pyridoxine combination for morning sickness.