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Blanche
Blanche (generic name: brompheniramine and phenylephrine) is a combination medication used to relieve symptoms associated with allergic rhinitis, hay fever, and the common cold. It combines an antihistamine (brompheniramine) to alleviate sneezing, runny nose, and itching, with a decongestant (phenylephrine) to reduce nasal congestion and sinus pressure.
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Frequently Asked Questions
How long does it take for Blanche to work?
Patients may start to notice relief within 30 minutes to 1 hour after taking Blanche, with effects lasting several hours.
Can Blanche be taken during pregnancy?
Blanche should be used during pregnancy only if the benefits outweigh the risks. Consult your healthcare provider for personalized advice.
What should I do if I miss a dose of Blanche?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Are there any dietary restrictions while taking Blanche?
There are no specific dietary restrictions while taking Blanche.
Is Blanche safe for long-term use?
Blanche is typically recommended for short-term use; prolonged use should be monitored by a healthcare provider to avoid tolerance and dependence.
Comprehensive Drug Guide
How Does Blanche Work?
- Blocking H1 histamine receptors: Brompheniramine inhibits the action of histamine, reducing symptoms such as sneezing, itching, and runny nose.
- Vasoconstriction: Phenylephrine acts on the alpha-adrenergic receptors in blood vessels, leading to vasoconstriction, which helps reduce nasal swelling and congestion.
Common Dosages
- Tablets: Usually available in strengths of 4 mg brompheniramine and 10 mg phenylephrine.
- Liquid formulations: Commonly available with similar active ingredient concentrations.
Typical Dosing
- For allergy relief: The usual adult dosage is 1 tablet taken every 4 to 6 hours, not exceeding 6 tablets in 24 hours. Liquid formulations should be taken as directed on the packaging.
Typical Dosing
FDA Approved Indications
- Relief of symptoms due to hay fever or other upper respiratory allergies.
- Temporary relief of nasal congestion associated with the common cold.
Who Shouldn't Take Blanche?
- Known hypersensitivity to brompheniramine, phenylephrine, or any components of the formulation.
- Severe hypertension or heart disease due to the effects of phenylephrine on blood pressure.
Advice From The Pharmacist
- Take Blanche exactly as directed on the package or by your healthcare provider, and do not exceed the recommended dosage.
- Be cautious when driving or operating machinery, as brompheniramine may cause drowsiness.
- Monitor for any signs of high blood pressure, such as headaches or palpitations, and consult your healthcare provider if these occur.
Side Effects of Blanche
Common Side Effects
- Drowsiness
- Dizziness
- Dry mouth
- Nausea
- Increased blood pressure
Uncommon/Severe Side Effects
- Severe allergic reactions (such as rash, itching, swelling, or difficulty breathing)
- Cardiovascular complications in sensitive individuals.
Risks and Warnings of Blanche
- Cognitive Effects: Use caution in elderly patients or those with preexisting conditions that may exacerbate side effects, as antihistamines can increase the risk of confusion and falls.
- Blood Pressure Monitoring: Patients with hypertension or cardiovascular conditions should monitor their blood pressure closely while using this medication.
Interactions with Blanche
Common Drug Interactions
- Other CNS depressants: Caution should be exercised when using Blanche with other medications that can cause sedation, such as alcohol or certain prescription medications.
- MAO inhibitors: Concurrent use with monoamine oxidase inhibitors should be avoided due to the risk of hypertensive crisis.
Alternatives to Blanche
- Other antihistamines: Such as loratadine or cetirizine, which may provide similar relief without the sedative effects of brompheniramine.
- Nasal corticosteroids: Such as fluticasone for more severe allergy symptoms.
