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Bexsero
Bexsero is a vaccine used to protect against invasive disease caused by Neisseria meningitidis serogroup B, a bacterium that can cause serious infections such as meningitis and septicemia. Bexsero is primarily used in individuals who are at increased risk for meningococcal disease, including those in outbreaks, individuals with certain medical conditions, and during routine immunization in some age groups.
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Frequently Asked Questions
How long does it take for Bexsero to start working?
Protection from Bexsero begins to develop within a few weeks after the first dose, but full protection is not achieved until after the second dose. It is important to complete the full vaccination series.
Can I get Bexsero if I am pregnant or breastfeeding?
The safety of Bexsero during pregnancy and breastfeeding has not been fully established. Women who are pregnant or breastfeeding should discuss the risks and benefits with their healthcare provider before receiving the vaccine.
What should I do if I miss the second dose of Bexsero?
If you miss the second dose, schedule it as soon as possible. While the timing of the second dose is important, it is better to complete the series late than not at all. Consult your healthcare provider for guidance on when to receive the missed dose.
Can Bexsero prevent all types of meningitis?
Bexsero specifically protects against Neisseria meningitidis serogroup B. It does not protect against other serogroups (such as A, C, W, or Y) or other types of meningitis caused by different bacteria or viruses. Additional vaccines may be required for broader protection.
Is Bexsero effective in preventing outbreaks of meningococcal disease?
Yes, Bexsero has been used effectively to help control outbreaks of meningococcal serogroup B disease, particularly in settings such as college campuses where close contact increases the risk of transmission.
Do I need a booster shot after receiving Bexsero?
Booster shots are generally not required for Bexsero; however, your healthcare provider will determine the best vaccination schedule for you.
Comprehensive Drug Guide
How Does Bexsero Work?
Bexsero works by introducing components of the Neisseria meningitidis serogroup B bacterium into the body, which stimulates the immune system to produce specific antibodies. These antibodies help protect against future infections by recognizing and neutralizing the bacteria if the individual is exposed to it. The vaccine targets several proteins found on the surface of the bacteria, providing broad protection against various strains within serogroup B.
What is Bexsero Used For?
Active Immunization Against Invasive Meningococcal Disease: Caused by Neisseria meningitidis serogroup B in individuals aged 10 to 25 years. It may also be used in other age groups depending on the risk of exposure.
Common Dosages
Administration: Bexsero is administered as an intramuscular injection, typically into the deltoid muscle of the upper arm. It is important to complete the full vaccination series to achieve optimal protection.
Timing: The second dose should be given at least one month after the first dose. The timing may vary depending on specific guidelines or the individual’s risk factors.
Typical Dosing
FDA Approved Indications
- Two-Dose Series: Each dose is 0.5 mL, given intramuscularly. The second dose is administered at least one month after the first dose.
- Alternative Schedules: In certain outbreak situations or for individuals at increased risk, a different schedule may be recommended by a healthcare provider.
Who Shouldn't Take Bexsero?
- Known hypersensitivity to any component of the vaccine or a previous dose of Bexsero.
- A history of severe allergic reactions (e.g., anaphylaxis) to vaccines.
Advice From The Pharmacist
- Complete the full vaccination series to ensure optimal protection against meningococcal disease.
- Report any unusual symptoms or side effects to their healthcare provider, especially if they experience severe allergic reactions, such as difficulty breathing, hives, or swelling of the face and throat.
- Be aware that mild side effects, such as pain at the injection site, fever, or fatigue, are common and typically resolve within a few days.
- Keep a record of the vaccination and inform any healthcare providers of their immunization status.
Side Effects of Bexsero
Common Side Effects
- Pain, redness, or swelling at the injection site
- Fever
- Fatigue
- Headache
- Muscle or joint pain
- Nausea
Uncommon/Severe Side Effects
- Severe Allergic Reactions: Such as anaphylaxis, which requires immediate medical attention.
- High Fever: In rare cases, individuals may develop a high fever following vaccination.
Patients should seek immediate medical attention if they experience signs of a severe allergic reaction or any other concerning symptoms.
Risks and Warnings of Bexsero
- Allergic Reactions: Although rare, Bexsero can cause severe allergic reactions. Patients should be monitored for at least 15 minutes after vaccination to ensure they do not have an adverse reaction.
- Febrile Seizures: While uncommon, febrile seizures may occur, particularly in young children who develop a fever after vaccination. Parents should monitor for fever and manage it appropriately with antipyretics if necessary.
Interactions with Bexsero
Common Drug Interactions
Bexsero may be administered concurrently with other vaccines; however, it should be given at a different injection site. There are no significant drug interactions with Bexsero, but patients should inform their healthcare provider of all medications and vaccines they have received.
Alternatives to Bexsero
- Trumenba: Another meningococcal group B vaccine that is administered as a three-dose series.
- Meningococcal Conjugate Vaccines (e.g., Menactra, Menveo): These vaccines protect against serogroups A, C, W, and Y but do not cover serogroup B.
The choice of vaccine depends on the individual’s age, risk factors, and specific circumstances, such as potential exposure to different serogroups.
