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Menactra
Menactra is a meningococcal conjugate vaccine used to help prevent infection caused by the bacteria Neisseria meningitidis. This vaccine protects against serogroups A, C, Y, and W-135 of the meningococcal bacteria, which can cause serious illnesses like meningitis (inflammation of the protective membranes around the brain and spinal cord) and septicemia (blood poisoning). Menactra is recommended for children, adolescents, and adults who are at higher risk of meningococcal infections, such as college students, military recruits, or travelers to areas where meningococcal disease is common.
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Frequently Asked Questions
How long does protection from Menactra last?
The protection from Menactra lasts several years, but a booster dose is recommended at age 16 for adolescents who received their first dose at 11-12 years old. People at continued high risk may require additional booster doses every 5 years.
Can Menactra be given with other vaccines?
Yes, Menactra can be administered at the same time as other vaccines, such as the HPV vaccine, but it should be given at a different injection site.
Is Menactra safe for pregnant women?
Menactra should only be given to pregnant women if clearly needed. There is limited data on the use of this vaccine during pregnancy, so it is important to discuss the potential risks and benefits with a healthcare provider.
What should I do if I miss a scheduled booster dose of Menactra?
If you or your child misses a booster dose, contact your healthcare provider to reschedule it as soon as possible. Staying up-to-date with booster doses is important to maintain protection against meningococcal disease.
Can Menactra cause meningitis?
No, Menactra cannot cause meningitis. It contains inactivated bacterial components that stimulate the immune system to protect against meningitis, but it does not contain live bacteria.
Comprehensive Drug Guide
How Does Menactra Work?
Menactra works by stimulating the body’s immune system to recognize and fight Neisseria meningitidis bacteria. The vaccine contains pieces of the bacteria’s polysaccharides (sugar molecules) attached to a protein, which helps the immune system identify and attack the bacteria if it enters the body in the future. By producing antibodies against the meningococcal bacteria, Menactra provides protection against the invasive diseases caused by the serogroups included in the vaccine.
Common Dosages
- For adolescents (11-18 years): One dose at age 11-12, with a booster at age 16.
- For adults (up to age 55) at high risk: One dose, with revaccination based on risk level and exposure.
Typical Dosing
- For children aged 9-23 months: Two doses, with the second dose given 3 months after the first.
- For individuals aged 2-55 years: A single dose, with boosters recommended for those at continued risk (e.g., travelers or individuals with certain medical conditions).
Typical Dosing
FDA Approved Indications
- Adolescents aged 11-12 years, with a booster dose at age 16.
- College students, military recruits, and travelers to high-risk areas.
- Individuals with certain medical conditions that increase their risk of meningococcal disease (e.g., asplenia or complement deficiencies).
Who Shouldn't Take Menactra?
- A known allergy or hypersensitivity to diphtheria toxoid or any component of the vaccine.
- A history of a severe allergic reaction (such as anaphylaxis) to a previous dose of meningococcal vaccine.
Advice From The Pharmacist
- Menactra is typically administered in the upper arm (deltoid muscle), and you may experience some soreness or redness at the injection site.
- The vaccine is recommended even for people who are traveling to countries where meningococcal disease is prevalent, such as parts of sub-Saharan Africa.
- If your child or adolescent receives the vaccine, ensure they receive their booster shot at the appropriate time (typically at age 16).
- Inform your healthcare provider of any allergies or history of vaccine reactions before getting Menactra.
- Common side effects include mild discomfort, and these typically resolve within a few days. Over-the-counter pain relievers like ibuprofen or acetaminophen can help ease soreness.
Side Effects of Menactra
Common Side Effects
- Pain, redness, or swelling at the injection site
- Mild fever
- Fatigue
- Headache
- Muscle or joint pain
Uncommon/Severe Side Effects
- Severe allergic reactions (such as anaphylaxis)
- Guillain-Barré Syndrome (a rare neurological disorder that causes muscle weakness)
Risks and Warnings of Menactra
- Allergic Reactions: While rare, some individuals may experience serious allergic reactions to Menactra. Symptoms of an allergic reaction include rash, difficulty breathing, swelling of the face or throat, and dizziness.
- Guillain-Barré Syndrome (GBS): Although there is a possible association between meningococcal vaccines and GBS, the risk is extremely low. Consult your doctor if you have a history of GBS before receiving Menactra.
- Fever and Irritability in Children: Young children who receive Menactra may develop mild fever and irritability, but these side effects are typically temporary.
Interactions with Menactra
Common Drug Interactions
- Other vaccines: Menactra can be given at the same time as other vaccines (e.g., HPV vaccine, tetanus vaccine), but it should be administered at a different injection site.
- Immunosuppressive medications: Individuals taking medications that suppress the immune system (such as corticosteroids or chemotherapy) may have a reduced response to Menactra.
Alternatives to Menactra
- Menveo: Another meningococcal conjugate vaccine that also protects against serogroups A, C, Y, and W-135.
- Bexsero: A meningococcal vaccine that protects against serogroup B (a different strain of Neisseria meningitidis).
- Trumenba: Another vaccine that provides protection against meningococcal serogroup B.
