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Bevespi Aerosphere
Bevespi Aerosphere is a combination inhalation aerosol that contains glycopyrrolate (an anticholinergic) and formoterol fumarate (a long-acting beta-agonist). It is used as a maintenance treatment to help control symptoms of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. Bevespi Aerosphere is not intended for the treatment of acute bronchospasm or asthma.
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Frequently Asked Questions
Can I use Bevespi Aerosphere for asthma?
No, Bevespi Aerosphere is not approved for the treatment of asthma and should not be used for this condition. It is specifically indicated for the maintenance treatment of COPD.
How long does it take for Bevespi Aerosphere to start working?
Bevespi Aerosphere works to provide long-term control of COPD symptoms. It does not provide immediate relief; therefore, it is important to use a rescue inhaler for sudden symptoms. Full benefits are typically seen after regular use.
What should I do if I miss a dose of Bevespi Aerosphere?
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take extra doses to make up for the missed one.
Is it safe to use Bevespi Aerosphere during pregnancy?
The safety of Bevespi Aerosphere during pregnancy has not been fully established. Pregnant women should consult their healthcare provider to discuss the potential risks and benefits before using this medication.
Can I use Bevespi Aerosphere with other inhalers?
Yes, Bevespi Aerosphere can be used in combination with other inhalers, such as short-acting bronchodilators (rescue inhalers). However, always consult your healthcare provider to ensure safe and effective use of multiple inhalers.
Comprehensive Drug Guide
How Does Bevespi Aerosphere Work?
The two active ingredients in Bevespi Aerosphere work together to improve breathing in patients with COPD:
- Glycopyrrolate blocks the action of acetylcholine on muscarinic receptors in the airways, leading to relaxation of the bronchial muscles and reducing bronchoconstriction.
- Formoterol Fumarate is a long-acting beta-2 agonist that stimulates the beta-2 receptors in the lungs, causing the bronchial muscles to relax and the airways to widen, which helps improve airflow and reduce symptoms of breathlessness.
What is Bevespi Aerosphere Used For?
- Maintenance Treatment of Chronic Obstructive Pulmonary Disease (COPD): Including chronic bronchitis and emphysema, to help control and prevent symptoms such as wheezing, shortness of breath, and chest tightness.
Common Dosages
- Two Inhalations Twice Daily: One in the morning and one in the evening, 12 hours apart. This provides a consistent level of medication throughout the day and night.
Typical Dosing
- Administration: Shake the inhaler well before each use. Exhale fully, place the mouthpiece in your mouth, and close your lips around it. As you begin to inhale deeply and slowly through your mouth, press down on the canister to release the medication. Continue to breathe in as deeply as possible, then hold your breath for 10 seconds or as long as comfortable. After the inhalation, remove the inhaler from your mouth and exhale slowly. Repeat for the second inhalation. Rinse your mouth with water and spit it out after using the inhaler to reduce the risk of oral thrush.
- Priming: If the inhaler is new or has not been used for more than 7 days, prime it by releasing 4 sprays into the air, away from your face.
- Cleaning: Clean the inhaler weekly by removing the canister and rinsing the mouthpiece under warm water, allowing it to air dry before reassembling.
Typical Dosing
Who Shouldn't Take Bevespi Aerosphere?
- Hypersensitivity to glycopyrrolate, formoterol fumarate, or any other components of the product.
- Severe hypersensitivity to milk proteins, as the inhaler may contain lactose.
Advice From The Pharmacist
- Use the inhaler regularly, twice daily, even if they feel well, to maintain control of COPD symptoms.
- Not use Bevespi Aerosphere to treat acute bronchospasm or sudden breathing problems; a rescue inhaler (such as albuterol) should be used in those situations.
- Rinse their mouth with water after each use to prevent oral thrush, a potential side effect of inhaled corticosteroids.
- Monitor their breathing and report any worsening of symptoms or increased use of rescue inhalers to their healthcare provider.
- Follow proper inhaler technique to ensure effective delivery of the medication.
Side Effects of Bevespi Aerosphere
Common Side Effects
- Cough
- Dry mouth
- Sore throat
- Muscle spasms
- Increased blood pressure
- Urinary tract infection (UTI)
Uncommon/Severe Side Effects
- Paradoxical Bronchospasm: A rare but serious condition where breathing or wheezing worsens immediately after using the inhaler.
- Cardiovascular Effects: Including increased heart rate, palpitations, and hypertension, especially in patients with a history of cardiovascular disease.
- Hypokalemia and Hyperglycemia: Long-acting beta-agonists like formoterol can affect electrolyte levels and blood sugar, requiring monitoring in susceptible patients.
Risks and Warnings of Bevespi Aerosphere
- Asthma-Related Death: Long-acting beta-agonists (LABAs) like formoterol increase the risk of asthma-related death when used as monotherapy. Bevespi Aerosphere is not approved for the treatment of asthma and should not be used for this condition.
- Worsening of Narrow-Angle Glaucoma: Glycopyrrolate can increase intraocular pressure; patients with narrow-angle glaucoma should use this medication with caution.
- Worsening of Urinary Retention: Glycopyrrolate can exacerbate urinary retention; patients with bladder neck obstruction or prostatic hyperplasia should use with caution.
Interactions with Bevespi Aerosphere
Common Drug Interactions
- Beta-Blockers: May reduce the effectiveness of formoterol and can worsen bronchospasm.
- Diuretics: Especially non-potassium-sparing diuretics, can increase the risk of hypokalemia when used with formoterol.
- MAO Inhibitors or Tricyclic Antidepressants: May enhance the effects of formoterol on the cardiovascular system.
Patients should inform their healthcare provider of all medications they are taking to avoid potential interactions.
Alternatives to Bevespi Aerosphere
- Other Combination Inhalers: Such as Anoro Ellipta (umeclidinium and vilanterol) or Stiolto Respimat (tiotropium and olodaterol), which also provide dual bronchodilation.
- Inhaled Corticosteroids: Combined with LABAs, such as Advair (fluticasone/salmeterol) or Symbicort (budesonide/formoterol).
- Short-Acting Bronchodilators: Such as albuterol or ipratropium for rescue use.
- Pulmonary Rehabilitation: A comprehensive program that includes exercise, education, and support for people with COPD.
