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Stiolto Respimat
Stiolto Respimat is the brand name for a combination inhalation medication containing tiotropium bromide and olodaterol. It is used for the long-term, once-daily maintenance treatment of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. Stiolto Respimat belongs to the class of long-acting muscarinic antagonists (LAMAs) and long-acting beta2-adrenergic agonists (LABAs). Together, these components help relax the muscles in the airways, improving airflow and reducing COPD symptoms such as shortness of breath.
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Frequently Asked Questions
How soon will Stiolto Respimat start to improve my breathing?
Stiolto Respimat is a long-acting medication, and it may take several days to feel the full benefits. Most patients notice improvement within the first week of regular use.
Can I use Stiolto Respimat as a rescue inhaler?
No, Stiolto Respimat is not meant for acute relief of breathing problems. Always have a rescue inhaler, like albuterol, on hand for sudden symptoms.
How do I clean my Stiolto Respimat inhaler?
Clean the mouthpiece with a damp cloth or tissue at least once a week to prevent medication buildup. Do not immerse the inhaler in water.
What happens if I miss a dose of Stiolto Respimat?
If you miss a dose, take it as soon as you remember, but do not double the dose if it is close to the next scheduled dose. Simply resume your normal dosing schedule.
Is Stiolto Respimat safe to use with other COPD medications?
Your healthcare provider will guide whether Stiolto Respimat can be safely combined with other COPD medications. Avoid combining it with other LAMAs or LABAs without medical advice, as this may increase the risk of side effects.
Comprehensive Drug Guide
How Does Stiolto Respimat Work?
- Tiotropium is a LAMA, which blocks muscarinic receptors in the airway muscles, preventing the constriction of airways and improving airflow.
- Olodaterol is a LABA, which stimulates beta2 receptors, leading to relaxation of the airway muscles. This helps open the airways, making breathing easier.
Together, these components work to keep the airways open, reduce COPD symptoms, and improve lung function.
Common Dosages
- Inhaler: Each inhalation delivers 2.5 mcg of tiotropium and 2.5 mcg of olodaterol, for a total of 5 mcg per dose.
Typical Dosing
- The recommended dose is two inhalations once daily, taken at the same time each day. It is important not to exceed the prescribed dose, as higher doses may not provide additional benefit and may increase the risk of side effects.
Typical Dosing
FDA Approved Indications
- Chronic Obstructive Pulmonary Disease (COPD), including chronic bronchitis and emphysema
It is not indicated for the treatment of asthma or for relief of acute bronchospasm.
Who Shouldn't Take Stiolto Respimat?
- Severe hypersensitivity to tiotropium, olodaterol, or any components of the inhaler.
- Asthma: It is not indicated for asthma treatment.
- Acute bronchospasm: It is not meant for use as a rescue inhaler for sudden breathing difficulties.
Advice From The Pharmacist
- Use Stiolto Respimat once a day at the same time to keep your COPD symptoms under control.
- Follow your doctor’s instructions for inhaler use. Ensure the inhaler is primed before the first use, and clean it once a week to ensure optimal function.
- Do not use Stiolto Respimat for sudden breathing problems—use a rescue inhaler (such as albuterol) for immediate relief.
- Store the inhaler at room temperature and keep it dry. Do not expose it to extreme heat or cold.
Side Effects of Stiolto Respimat
Common Side Effects
- Cough
- Upper respiratory tract infections
- Back pain
- Dry mouth
Uncommon/Severe Side Effects
- Paradoxical bronchospasm (worsening breathing problems)
- Rapid heart rate (tachycardia)
- Urinary retention
- Allergic reactions (such as hives, swelling, or difficulty breathing)
Risks and Warnings of Stiolto Respimat
- Paradoxical Bronchospasm: In rare cases, Stiolto Respimat can cause worsening breathing difficulties. If this occurs, discontinue use and seek immediate medical attention.
- Cardiovascular Risks: Olodaterol may increase the risk of cardiovascular side effects, such as increased heart rate or arrhythmias.
- Glaucoma and Urinary Retention: Tiotropium may worsen narrow-angle glaucoma or cause urinary retention in susceptible individuals. Patients with a history of these conditions should use Stiolto Respimat with caution.
Interactions with Stiolto Respimat
Common Drug Interactions
- Beta-blockers: These medications may reduce the effectiveness of olodaterol, as both drugs affect the beta-receptors in the body.
- Other anticholinergics: Combining Stiolto Respimat with other anticholinergic medications may increase the risk of side effects, such as dry mouth or urinary retention.
- Sympathomimetic drugs: The combination with other sympathomimetic drugs (e.g., albuterol) may increase cardiovascular side effects like increased heart rate or high blood pressure.
Alternatives to Stiolto Respimat
- Anoro Ellipta: Contains umeclidinium and vilanterol, another combination of LAMA and LABA for COPD treatment.
- Trelegy Ellipta: Contains fluticasone, umeclidinium, and vilanterol, offering an option for those needing triple therapy for COPD.
- Spiriva Respimat: Contains tiotropium, a LAMA, and is used for COPD maintenance treatment.
- Advair Diskus: Combines fluticasone and salmeterol, a corticosteroid and LABA combination used in COPD and asthma.
