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Azilect
Azilect (rasagiline) is a monoamine oxidase-B (MAO-B) inhibitor used to treat Parkinson’s disease. It is often prescribed to help improve symptoms such as tremors, stiffness, and difficulty with movement by increasing the levels of dopamine in the brain. Azilect can be used as monotherapy in early-stage Parkinson's disease or in combination with levodopa in more advanced stages to enhance its effectiveness and reduce motor fluctuations.
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Frequently Asked Questions
How long does it take for Azilect to start working?
Azilect typically begins to improve symptoms within a few weeks of starting treatment, but it may take longer to experience full benefits.
Can I take Azilect with other Parkinson’s medications?
Yes, Azilect is often used in combination with other Parkinson’s medications like levodopa or dopamine agonists. However, your healthcare provider may adjust the dosage of these medications to avoid side effects like dyskinesia.
Are there any dietary restrictions while taking Azilect?
Yes, you should avoid foods high in tyramine, such as aged cheeses, cured meats, and certain wines, as they can interact with Azilect and cause a dangerous increase in blood pressure (hypertensive crisis).
Can Azilect cause weight gain?
Weight gain is not a common side effect of Azilect. However, other Parkinson’s medications or changes in physical activity may contribute to weight changes.
Can I drink alcohol while taking Azilect?
Moderate alcohol consumption may be allowed, but you should avoid tyramine-rich alcoholic beverages like beer on tap or aged wines, as they can increase the risk of hypertensive crisis. Always consult your healthcare provider regarding alcohol use while on Azilect.
Comprehensive Drug Guide
How Does Azilect Work?
Azilect works by inhibiting monoamine oxidase-B (MAO-B), an enzyme that breaks down dopamine in the brain. By blocking this enzyme, Azilect increases the availability of dopamine, which helps improve motor control and reduce symptoms of Parkinson’s disease, such as tremors and muscle stiffness.
Common Dosages
- Tablets: 0.5 mg and 1 mg
Typical Dosing
- The typical starting dose for monotherapy in early-stage Parkinson’s disease is 1 mg once daily.
- When used in combination with levodopa, the dose may be 0.5 mg to 1 mg once daily, depending on the patient’s response and side effects.
Typical Dosing
FDA Approved Indications
- Parkinson’s disease as monotherapy in early stages or in combination with levodopa in more advanced stages.
Who Shouldn't Take Azilect?
- Severe liver impairment
- Concurrent use of certain medications, including meperidine, tramadol, methadone, or other MAO inhibitors
- Known hypersensitivity to rasagiline or any component of the formulation
Advice From The Pharmacist
- Take Azilect once daily, with or without food, at the same time each day.
- Avoid foods high in tyramine, such as aged cheeses, cured meats, and fermented products, as they may interact with Azilect and increase the risk of hypertensive crisis.
- Azilect can be used alone or with other Parkinson’s medications like levodopa, but it may require dose adjustments to avoid side effects.
- Inform your healthcare provider about all medications, as Azilect can interact with several drugs, including antidepressants and opioid pain relievers.
Side Effects of Azilect
Common Side Effects
- Headache
- Dizziness
- Joint pain
- Indigestion
- Depression
Uncommon/Severe Side Effects
- Hypertension (high blood pressure)
- Hallucinations
- Serotonin syndrome when taken with other serotonergic drugs
- Orthostatic hypotension (low blood pressure when standing)
Risks and Warnings of Azilect
- Hypertensive crisis: Consuming high-tyramine foods while taking Azilect can lead to a dangerous increase in blood pressure. Avoid aged cheeses, smoked meats, and certain alcoholic beverages.
- Serotonin syndrome: Combining Azilect with other medications that affect serotonin (such as SSRIs, SNRIs, or tramadol) can lead to serotonin syndrome, a potentially life-threatening condition characterized by symptoms such as agitation, confusion, rapid heart rate, and high blood pressure.
- Dyskinesia: When used with levodopa, Azilect may increase the risk of dyskinesias (involuntary movements), which may require levodopa dose adjustments.
Interactions with Azilect
Common Drug Interactions
- Antidepressants: Use of Azilect with SSRIs, SNRIs, or tricyclic antidepressants increases the risk of serotonin syndrome. Close monitoring is required.
- Opioids: Azilect should not be used with certain opioids like meperidine, tramadol, or methadone, as it can result in severe reactions, including serotonin syndrome or hypertensive crisis.
- Ciprofloxacin: This antibiotic may increase rasagiline levels in the blood, potentially leading to an increased risk of side effects. Dosage adjustments may be necessary.
Alternatives to Azilect
- Selegiline: Another MAO-B inhibitor used for Parkinson’s disease, available in both oral and transdermal patch forms.
- Levodopa/carbidopa: The gold-standard treatment for Parkinson’s disease, often used in combination with MAO-B inhibitors like Azilect for better symptom control.
- Dopamine agonists (e.g., pramipexole, ropinirole): These medications mimic the effects of dopamine in the brain and are used to treat Parkinson’s disease.