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Avodart
Avodart (dutasteride) is a 5-alpha-reductase inhibitor used to treat benign prostatic hyperplasia (BPH), also known as an enlarged prostate, in men. It works by reducing the size of the prostate, improving urinary flow, and decreasing symptoms like difficulty urinating, frequent urination, and the sensation of incomplete bladder emptying. Avodart is often prescribed in combination with other medications, such as alpha-blockers, to provide comprehensive management of BPH symptoms.
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Frequently Asked Questions
How long does it take for Avodart to start working?
It may take 3 to 6 months of consistent use before you notice a significant reduction in prostate size and improvement in urinary symptoms.
Can Avodart cause sexual side effects?
Yes, some men may experience decreased libido, erectile dysfunction, or reduced semen volume. These side effects may persist even after stopping the medication in some cases.
Should I stop taking Avodart if my symptoms improve?
No, Avodart should be continued as prescribed, even if your symptoms improve. Stopping the medication may cause your symptoms to return or worsen over time.
Can women take Avodart?
No, Avodart is not indicated for use in women, particularly pregnant women, as it can cause harm to a male fetus.
Can I take Avodart with other BPH medications?
Yes, Avodart is often prescribed in combination with alpha-blockers like tamsulosin for enhanced symptom relief. However, always follow your healthcare provider's instructions regarding medication combinations.
Comprehensive Drug Guide
How Does Avodart Work?
Avodart works by inhibiting 5-alpha-reductase, an enzyme that converts testosterone into dihydrotestosterone (DHT), a hormone that contributes to prostate growth. By lowering DHT levels, Avodart helps shrink the prostate gland, relieving symptoms of BPH and reducing the need for surgery to treat the condition.
Common Dosages
- Capsules: 0.5 mg
Typical Dosing
- The recommended dose of Avodart for the treatment of BPH is 0.5 mg once daily, taken with or without food.
- It may take 3 to 6 months of regular use to see the full benefits of Avodart in reducing prostate size and improving urinary symptoms.
Typical Dosing
FDA Approved Indications
- Benign prostatic hyperplasia (BPH) in men with an enlarged prostate
- Reducing the risk of acute urinary retention and the need for BPH-related surgery
Who Shouldn't Take Avodart?
- Known hypersensitivity to dutasteride or any component of the formulation
- Pregnancy: Avodart is contraindicated for use in women, particularly during pregnancy, as it can cause harm to a male fetus.
- Children: Avodart is not indicated for use in pediatric patients.
Advice From The Pharmacist
- Avodart should be taken consistently at the same time each day for the best results. It may take several months to experience symptom relief, so continue taking the medication as prescribed.
- Pregnant women should not handle Avodart capsules, as the active ingredient can be absorbed through the skin and may harm a developing male fetus.
- Be aware that Avodart can lower prostate-specific antigen (PSA) levels, which may affect prostate cancer screening results. Inform your healthcare provider that you are taking Avodart before undergoing PSA tests.
Side Effects of Avodart
Common Side Effects
- Decreased libido
- Erectile dysfunction
- Decreased semen volume
- Breast tenderness or enlargement (gynecomastia)
Uncommon/Severe Side Effects
- Allergic reactions, such as rash, itching, or swelling
- Depression or mood changes
- Potential increased risk of high-grade prostate cancer
Risks and Warnings of Avodart
- Prostate cancer risk: While Avodart lowers the risk of developing prostate cancer overall, some studies suggest it may increase the risk of developing high-grade prostate cancer. Regular monitoring and screening are recommended.
- Sexual side effects: Avodart may cause decreased sexual desire, erectile dysfunction, and reduced semen production. These side effects may persist after stopping the medication in some cases.
- Blood donation: Men taking Avodart should not donate blood until at least 6 months after stopping the medication, as it could pose a risk to pregnant women who receive the blood.
Interactions with Avodart
Common Drug Interactions
- CYP3A4 inhibitors: Medications such as ketoconazole, ritonavir, or clarithromycin can increase the concentration of Avodart in the blood, potentially leading to an increased risk of side effects.
- Alpha-blockers: Avodart is often used in combination with alpha-blockers like tamsulosin for enhanced symptom relief, but this may increase the risk of low blood pressure and dizziness.
- Warfarin: Avodart may interact with blood thinners like warfarin, affecting blood clotting times. Regular monitoring is recommended if taken together.
Alternatives to Avodart
- Finasteride (Proscar): Another 5-alpha-reductase inhibitor used to treat BPH, but with a slightly different mechanism of action.
- Tamsulosin (Flomax): An alpha-blocker used to relax the muscles in the prostate and bladder neck, making it easier to urinate.
- Surgical options: For men with severe BPH symptoms, surgical interventions such as transurethral resection of the prostate (TURP) may be considered.
