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Apadaz
Apadaz is a combination medication containing benzhydrocodone and acetaminophen. It is prescribed for the short-term treatment of acute pain severe enough to require an opioid and when other pain medications are not sufficient. Benzhydrocodone is an opioid prodrug that converts to hydrocodone in the body, while acetaminophen is a non-opioid pain reliever and fever reducer. Together, these ingredients work to relieve moderate to severe pain. Apadaz is generally used in situations where fast pain relief is required but for short durations.
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Frequently Asked Questions
How quickly does Apadaz start working?
Apadaz typically starts to relieve pain within 30 to 60 minutes after taking a dose. The pain-relieving effects usually last about 4 to 6 hours.
Can I take Apadaz if I am pregnant?
Apadaz is not recommended during pregnancy due to the risk of neonatal opioid withdrawal syndrome and other potential risks to the fetus. Always consult your healthcare provider before taking any medication during pregnancy.
What should I do if I miss a dose of Apadaz?
If you miss a dose of Apadaz, take it as soon as you remember. If it is close to the time of your next dose, skip the missed dose—do not double the dose to catch up.
Can I take Apadaz with over-the-counter pain medications?
You should avoid taking additional acetaminophen-containing medications while using Apadaz, as it can increase the risk of liver damage. Consult your doctor before combining it with other pain medications.
Is Apadaz addictive?
Yes, Apadaz contains an opioid (benzhydrocodone), which can be habit-forming. It should only be used under the guidance of a healthcare provider for short-term pain management.
Comprehensive Drug Guide
How Does Apadaz Work?
Apadaz combines the actions of benzhydrocodone and acetaminophen. Benzhydrocodone is converted to hydrocodone in the body, where it binds to mu-opioid receptors in the brain and spinal cord to reduce the perception of pain. Acetaminophen works by inhibiting the production of prostaglandins in the brain, which helps to reduce pain and lower fever.
Common Dosages
- Tablets: Each tablet contains 6.12 mg of benzhydrocodone and 325 mg of acetaminophen.
Typical Dosing
- The usual dose is 1 or 2 tablets every 4 to 6 hours as needed for pain.
- Do not exceed 12 tablets in 24 hours due to the risk of acetaminophen toxicity.
Typical Dosing
FDA Approved Indications
- Acute pain that is severe enough to require an opioid, particularly in cases where non-opioid alternatives are inadequate
Who Shouldn't Take Apadaz?
- Severe respiratory depression
- Acute or severe bronchial asthma without resuscitative equipment
- Known hypersensitivity to hydrocodone, acetaminophen, or any component of the formulation
- Paralytic ileus
Advice From The Pharmacist
- Take Apadaz exactly as prescribed to minimize the risk of addiction, overdose, and respiratory depression.
- Avoid taking more than the recommended dose, as exceeding the acetaminophen limit can lead to liver damage.
- Do not drink alcohol while taking Apadaz, as it can increase the risk of liver damage and sedation.
- If you experience dizziness or drowsiness, avoid driving or operating heavy machinery.
- Store Apadaz in a secure place away from others, particularly children and individuals with a history of substance abuse.
Side Effects of Apadaz
Common Side Effects
- Drowsiness
- Dizziness
- Nausea
- Constipation
Uncommon/Severe Side Effects
- Respiratory depression (slow or shallow breathing)
- Severe liver damage (especially with acetaminophen overdose)
- Addiction or dependence
- Allergic reactions (swelling, rash, difficulty breathing)
Risks and Warnings of Apadaz
- Risk of addiction, abuse, and misuse: Apadaz contains an opioid and can be habit-forming. It should only be used for the prescribed duration, and under close medical supervision.
- Respiratory depression: High doses or combining Apadaz with other sedatives or alcohol can cause life-threatening respiratory depression.
- Liver toxicity: Exceeding the maximum daily dose of acetaminophen (4,000 mg) can cause severe liver damage, leading to liver failure or death.
- Withdrawal symptoms: Stopping Apadaz suddenly after prolonged use can lead to opioid withdrawal symptoms, such as restlessness, sweating, and nausea.
Interactions with Apadaz
Common Drug Interactions
- Benzodiazepines and other CNS depressants: Taking Apadaz with medications like benzodiazepines or alcohol can increase the risk of sedation, respiratory depression, and overdose.
- MAO inhibitors: Using Apadaz with MAO inhibitors (or within 14 days of stopping them) can cause dangerous drug interactions.
- Anticholinergic drugs: Combining Apadaz with anticholinergic drugs can increase the risk of urinary retention and constipation.
Alternatives to Apadaz
- Oxycodone/acetaminophen (Percocet): Another combination opioid and non-opioid medication for acute pain.
- Hydrocodone/acetaminophen (Norco, Vicodin): Similar to Apadaz but with hydrocodone in its active form.
- Ibuprofen: A non-opioid pain reliever that may be sufficient for mild to moderate pain in some cases.
- Tramadol: A weaker opioid that is sometimes used for moderate pain and has a lower risk of abuse.
