Amphetamine Sulfate

The typical dosing for Amphetamine Sulfate varies based on the condition being treated:

• ADHD: Start with 5 mg once or twice daily. The dosage may be increased by 5 mg at weekly intervals, with a maximum dose of 40 mg per day.
• Narcolepsy: Start with 10 mg once daily, which may be increased by 10 mg at weekly intervals, with a typical maintenance dose ranging from 20 mg to 60 mg per day.

• Off-label uses: It's also used to help individuals with obesity lose weight.

Amphetamine Sulfate should not be used in patients with:

• Advanced arteriosclerosis
• Symptomatic cardiovascular disease
• Moderate to severe hypertension
• Hyperthyroidism
• Glaucoma
• Known hypersensitivity or idiosyncratic reactions to amphetamines
• A history of drug abuse
• Concurrent use of monoamine oxidase inhibitors (MAOIs) or within 14 days of discontinuing MAOIs

Patients taking Amphetamine Sulfate should:

• Take the medication exactly as prescribed, typically in the morning to avoid insomnia.
• Avoid alcohol, as it can increase the risk of side effects such as dizziness or impaired judgment.
• Be aware of the potential for abuse and dependence, and use the medication only as directed.
• Monitor blood pressure and heart rate regularly, especially if they have a history of cardiovascular disease.
• Inform their healthcare provider if they experience any significant mood changes, such as increased agitation, aggression, or depression.
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Common side effects of Amphetamine Sulfate include:

• Insomnia
• Decreased appetite
• Dry mouth
• Anxiety
• Increased heart rate (tachycardia)

Serious side effects may include:

• Hypertension (high blood pressure)
• Cardiovascular events (e.g., heart attack, stroke)
• Psychiatric symptoms (e.g., psychosis, mania)
• Growth suppression in children with long-term use
• Dependence and withdrawal symptoms

• Amphetamine can lead to an increased heart rate and blood pressure, making it unsuitable for people with heart conditions.
• People with a history of drug addiction should also avoid it due to the high risk of dependency.
• If you're going through pregnancy or planning to become pregnant, consult your doctor since the effects of amphetamine on the unborn baby aren't known.
• Use caution if you have seizures or epilepsy, as amphetamine can induce seizures in some people.
• If you have an overactive thyroid glaucoma or an overexcited state, amphetamine use may not be suitable.
• Finally, individuals who have taken MAOIs within the last two weeks should not use amphetamine due to the risk of severe, life-threatening side effects.

Amphetamine Sulfate may interact with:

• Monoamine Oxidase Inhibitors (MAOIs): Increased risk of hypertensive crisis. Do not use concurrently or within 14 days of MAOI therapy.
• Antihypertensive Medications: May reduce the effectiveness of blood pressure-lowering drugs.
• Acidifying Agents: May decrease the effectiveness of Amphetamine Sulfate by increasing urinary excretion.
• Alkalinizing Agents: May increase the effectiveness of Amphetamine Sulfate by decreasing urinary excretion.

Patients should inform their healthcare provider of all medications, supplements, and herbal products they are taking to avoid potential drug interactions.

Alternative medications to Amphetamine Sulfate include:

• Methylphenidate (Ritalin): Another CNS stimulant used to treat ADHD and narcolepsy.
• Lisdexamfetamine (Vyvanse): A prodrug of dextroamphetamine used for ADHD and binge eating disorder.
• Atomoxetine (Strattera): A non-stimulant medication for ADHD that works by inhibiting norepinephrine reuptake.