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amLODIPine-Olmesartan
amLODIPine-Olmesartan is a combination medication used to treat high blood pressure (hypertension). It contains two active ingredients: amlodipine, a calcium channel blocker, and olmesartan, an angiotensin II receptor blocker (ARB). Amlodipine helps relax blood vessels, allowing blood to flow more easily, while olmesartan blocks the action of angiotensin II, a hormone that narrows blood vessels. This combination effectively lowers blood pressure and reduces the risk of cardiovascular events such as heart attacks and strokes.
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Frequently Asked Questions
Can amLODIPine-Olmesartan be taken with other blood pressure medications?
Yes, amLODIPine-Olmesartan can be used in combination with other antihypertensive medications. However, careful monitoring of blood pressure and potassium levels is necessary, and dose adjustments may
How should amLODIPine-Olmesartan be stored?
Store amLODIPine-Olmesartan at room temperature, away from moisture and light. Ensure that it is kept out of reach of children and pets.
Is amLODIPine-Olmesartan safe during pregnancy?
No, amLODIPine-Olmesartan is contraindicated during pregnancy due to the risk of fetal harm. Women of childbearing potential should use effective contraception while taking this medication.
What should I do if I miss a dose of amLODIPine-Olmesartan?
If you miss a dose, take it as soon as you remember, unless it is close to the time for your next dose. Do not double up on doses to make up for a missed one.
Comprehensive Drug Guide
How Does amLODIPine-Olmesartan Work?
amLODIPine-Olmesartan works through two complementary mechanisms. Amlodipine, a calcium channel blocker, inhibits the influx of calcium ions into vascular smooth muscle and cardiac muscle, leading to vasodilation and reduced blood pressure. Olmesartan, an ARB, blocks the binding of angiotensin II to its receptors, preventing vasoconstriction and reducing the secretion of aldosterone, which decreases blood volume. Together, these actions help lower blood pressure effectively.
Common Dosages
amLODIPine-Olmesartan is commonly available in the following dosage combinations:
- 5 mg/20 mg tablets (amlodipine/olmesartan)
- 5 mg/40 mg tablets (amlodipine/olmesartan)
- 10 mg/40 mg tablets (amlodipine/olmesartan)
Typical Dosing
The typical dosing for amLODIPine-Olmesartan is:
- Adults: Start with 1 tablet (e.g., 5 mg/20 mg) once daily. The dosage may be adjusted based on the patient’s response, with a maximum dose of 10 mg/40 mg per day.
Elderly: Dose adjustments may be required based on the patient's response and tolerance.
Typical Dosing
FDA Approved Indications
amLODIPine-Olmesartan is FDA-approved for the treatment of:
- Hypertension (high blood pressure) in patients who require treatment with both a calcium channel blocker and an ARB.
Off-Label Uses
There are no widely recognized off-label uses for this combination medication.
Who Shouldn't Take amLODIPine-Olmesartan?
amLODIPine-Olmesartan should not be used in patients with:
- Severe renal impairment or dialysis
- Known hypersensitivity to amlodipine, olmesartan, or any of the components of the drug
- Pregnancy (due to the risk of fetal harm)
- Severe hypotension (low blood pressure)
Advice From The Pharmacist
Patients taking amLODIPine-Olmesartan should:
- Take the medication as prescribed, typically once daily, with or without food.
- Monitor blood pressure regularly and report any significant changes to their healthcare provider.
- Avoid potassium supplements or potassium-rich foods (e.g., bananas, oranges) unless directed by a healthcare provider, as this may increase the risk of hyperkalemia.
- Be aware of signs of angioedema (e.g., swelling of the face, lips, tongue) and seek immediate medical attention if these symptoms occur.
Side Effects of amLODIPine-Olmesartan
Common Side Effects
Common side effects of amLODIPine-Olmesartan include:
- Dizziness
- Headache
- Fatigue
- Edema (swelling)
Uncommon/Severe Side Effects
Serious side effects may include:
- Hyperkalemia (elevated potassium levels)
- Angioedema (swelling of the deeper layers of the skin)
- Severe hypotension (low blood pressure)
- Kidney dysfunction
Risks and Warnings of amLODIPine-Olmesartan
Major risks and warnings associated with amLODIPine-Olmesartan include:
- Angioedema: ARBs like olmesartan can cause angioedema, a potentially life-threatening condition characterized by swelling of the face, throat, and extremities. Patients with a history of angioedema should not use this medication.
- Hyperkalemia: The use of ARBs can lead to elevated potassium levels, which can be dangerous, especially in patients with renal impairment or those taking potassium-sparing diuretics.
- Fetal Toxicity: ARBs are contraindicated during pregnancy due to the risk of fetal harm. Women of childbearing potential should use effective contraception while taking this medication.
- Hypotension: This medication can cause a significant drop in blood pressure, particularly in patients who are volume-depleted or taking other antihypertensive medications.
Interactions with amLODIPine-Olmesartan
Common Drug Interactions
amLODIPine-Olmesartan may interact with:
- Potassium supplements and potassium-sparing diuretics: Increased risk of hyperkalemia.
- NSAIDs: May reduce the antihypertensive effect and increase the risk of kidney damage.
- Lithium: Increased risk of lithium toxicity when taken with ARBs.
Patients should inform their healthcare provider of all medications, supplements, and herbal products they are taking to avoid potential drug interactions.
Alternatives to amLODIPine-Olmesartan
Alternative medications to amLODIPine-Olmesartan include:
- Lisinopril-hydrochlorothiazide: A combination of an ACE inhibitor and a thiazide diuretic for hypertension.
- Losartan-hydrochlorothiazide: A combination of an ARB and a thiazide diuretic used for blood pressure management.
- Valsartan-amlodipine (Exforge): Another combination of an ARB and a calcium channel blocker used for hypertension.
