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amLODIPine Besylate-Valsartan
amLODIPine Besylate-Valsartan is a combination medication used to treat high blood pressure (hypertension). It combines two active ingredients: amlodipine, a calcium channel blocker, and valsartan, an angiotensin II receptor blocker (ARB). Amlodipine works by relaxing blood vessels, allowing blood to flow more easily, while valsartan blocks the action of angiotensin II, a substance in the body that narrows blood vessels. This combination helps to effectively lower blood pressure and reduce the risk of cardiovascular events, such as heart attacks and strokes.
Drug Availability and Controlled Substance Status
amLODIPine Besylate-Valsartan is available in oral tablet form with various dosage combinations, including 5 mg/160 mg, 10 mg/160 mg, and 5 mg/320 mg (amlodipine/valsartan). It is not classified as a controlled substance, making it available with a prescription without the regulatory restrictions that apply to controlled drugs.
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Frequently Asked Questions
Can amLODIPine Besylate-Valsartan be taken with other blood pressure medications?
Yes, amLODIPine Besylate-Valsartan can be used in combination with other antihypertensive medications. However, careful monitoring of blood pressure and potassium levels is necessary, and dose adjustments may be required.
How should amLODIPine Besylate-Valsartan be stored?
Store amLODIPine Besylate-Valsartan at room temperature, away from moisture and light. Ensure that it is kept out of reach of children and pets.
Is amLODIPine Besylate-Valsartan safe during pregnancy?
No, amLODIPine Besylate-Valsartan is contraindicated during pregnancy due to the risk of fetal harm. Women of childbearing potential should use effective contraception while taking this medication.
What should I do if I miss a dose of amLODIPine Besylate-Valsartan?
If you miss a dose, take it as soon as you remember, unless it is close to the time for your next dose. Do not double up on doses to make up for a missed one.
Comprehensive Drug Guide
How Does amLODIPine Besylate-Valsartan Work?
amLODIPine Besylate-Valsartan works through two complementary mechanisms. Amlodipine, a calcium channel blocker, inhibits the influx of calcium ions into vascular smooth muscle and cardiac muscle, leading to vasodilation and reduced blood pressure. Valsartan, an ARB, blocks the binding of angiotensin II to its receptors, preventing vasoconstriction and reducing the secretion of aldosterone, which decreases blood volume. Together, these actions help to lower blood pressure effectively.
What is amLODIPine Besylate-Valsartan Used For?
Common Dosages
amLODIPine Besylate-Valsartan is commonly available in the following dosage combinations:
- 5 mg/160 mg tablets (amlodipine/valsartan)
- 10 mg/160 mg tablets (amlodipine/valsartan)
- 5 mg/320 mg tablets (amlodipine/valsartan)
- 10 mg/320 mg tablets (amlodipine/valsartan)
Typical Dosing
The typical dosing for amLODIPine Besylate-Valsartan is:
- Adults: Start with 1 tablet (e.g., 5 mg/160 mg) once daily. The dosage may be adjusted based on the patient’s response, with a maximum dose of 10 mg/320 mg per day.
- Elderly: Dose adjustments may be required based on the patient's response and tolerance.
Typical Dosing
FDA Approved Indications
amLODIPine Besylate-Valsartan is FDA-approved for the treatment of:
- Hypertension (high blood pressure) in patients whose blood pressure is not adequately controlled with monotherapy or who require multiple antihypertensive agents.
There are no widely recognized off-label uses for this combination medication.
Who Shouldn't Take amLODIPine Besylate-Valsartan?
amLODIPine Besylate-Valsartan should not be used in patients with:
- Severe renal impairment or dialysis
- Known hypersensitivity to amlodipine, valsartan, or any of the components of the drug
- Pregnancy (due to the risk of fetal harm)
- Severe hypotension (low blood pressure)
Advice From The Pharmacist
Patients taking amLODIPine Besylate-Valsartan should:
- Take the medication as prescribed, typically once daily, with or without food.
- Monitor blood pressure regularly and report any significant changes to their healthcare provider.
- Avoid potassium supplements or potassium-rich foods (e.g., bananas, oranges) unless directed by a healthcare provider, as this may increase the risk of hyperkalemia.
- Be aware of signs of angioedema (e.g., swelling of the face, lips, tongue) and seek immediate medical attention if these symptoms occur.
Side Effects of amLODIPine Besylate-Valsartan
Common Side Effects
Common side effects of amLODIPine Besylate-Valsartan include:
- Dizziness
- Headache
- Fatigue
- Edema (swelling)
Uncommon/Severe Side Effects
Serious side effects may include:
- Hyperkalemia (elevated potassium levels)
- Angioedema (swelling of the deeper layers of the skin)
- Severe hypotension (low blood pressure)
- Kidney dysfunction
Risks and Warnings of amLODIPine Besylate-Valsartan
Major risks and warnings associated with amLODIPine Besylate-Valsartan include:
- Angioedema: ARBs like valsartan can cause angioedema, a potentially life-threatening condition characterized by swelling of the face, throat, and extremities. Patients with a history of angioedema should not use this medication.
- Hyperkalemia: The use of ARBs can lead to elevated potassium levels, which can be dangerous, especially in patients with renal impairment or those taking potassium-sparing diuretics.
- Fetal Toxicity: ARBs are contraindicated during pregnancy due to the risk of fetal harm. Women of childbearing potential should use effective contraception while taking this medication.
- Hypotension: This medication can cause a significant drop in blood pressure, particularly in patients who are volume-depleted or taking other antihypertensive medications.
Interactions with amLODIPine Besylate-Valsartan
Common Drug Interactions
amLODIPine Besylate-Valsartan may interact with:
- Potassium supplements and potassium-sparing diuretics: Increased risk of hyperkalemia.
- NSAIDs: May reduce the antihypertensive effect and increase the risk of kidney damage.
- Lithium: Increased risk of lithium toxicity when taken with ARBs.
Patients should inform their healthcare provider of all medications, supplements, and herbal products they are taking to avoid potential drug interactions.
Alternatives to amLODIPine Besylate-Valsartan
Alternative medications to amLODIPine Besylate-Valsartan include:
- Lisinopril-hydrochlorothiazide: A combination of an ACE inhibitor and a thiazide diuretic for hypertension.
- Losartan-hydrochlorothiazide: A combination of an ARB and a thiazide diuretic used for blood pressure management.
- Olmesartan-amlodipine (Azor): Another combination of an ARB and a calcium channel blocker used for hypertension.
