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amLODIPine Besy-Benazepril HCl
amLODIPine Besy-Benazepril HCl is a combination medication used to treat high blood pressure (hypertension). It combines two active ingredients: amlodipine, a calcium channel blocker, and benazepril, an angiotensin-converting enzyme (ACE) inhibitor. Amlodipine works by relaxing the blood vessels, allowing blood to flow more easily, while benazepril reduces the production of a substance that tightens blood vessels, further lowering blood pressure. This combination is often prescribed when one medication alone is insufficient to control hypertension.
Drug Availability and Controlled Substance Status
amLODIPine Besy-Benazepril HCl is available in oral capsule form with various dosage combinations, including 2.5 mg/10 mg, 5 mg/10 mg, and 10 mg/20 mg (amlodipine/benazepril). It is not classified as a controlled substance, making it available with a prescription without the regulatory restrictions that apply to controlled drugs.
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Frequently Asked Questions
Can amLODIPine Besy-Benazepril HCl be taken with other blood pressure medications?
Yes, amLODIPine Besy-Benazepril HCl can be used in combination with other antihypertensive medications. However, careful monitoring of blood pressure and potassium levels is necessary, and dose adjustments may be required.
How should amLODIPine Besy-Benazepril HCl be stored?
Store amLODIPine Besy-Benazepril HCl at room temperature, away from moisture and light. Ensure that it is kept out of reach of children and pets.
Is amLODIPine Besy-Benazepril HCl safe during pregnancy?
No, amLODIPine Besy-Benazepril HCl is contraindicated during pregnancy due to the risk of fetal harm. Women of childbearing potential should use effective contraception while taking this medication.
What should I do if I miss a dose of amLODIPine Besy-Benazepril HCl?
If you miss a dose, take it as soon as you remember, unless it is close to the time for your next dose. Do not double up on doses to make up for a missed one.
Comprehensive Drug Guide
How Does amLODIPine Besy-Benazepril HCl Work?
amLODIPine Besy-Benazepril HCl works through two complementary mechanisms. Amlodipine, a calcium channel blocker, inhibits the influx of calcium ions into vascular smooth muscle and cardiac muscle, leading to relaxation and vasodilation, which reduces blood pressure. Benazepril, an ACE inhibitor, blocks the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, thus reducing blood vessel constriction and promoting blood flow. Together, these actions help to effectively lower blood pressure.
What is amLODIPine Besy-Benazepril HCl Used For?
Common Dosages
amLODIPine Besy-Benazepril HCl is commonly available in the following dosage combinations:
- 2.5 mg/10 mg capsules (amlodipine/benazepril)
- 5 mg/10 mg capsules (amlodipine/benazepril)
- 10 mg/20 mg capsules (amlodipine/benazepril)
Typical Dosing
The typical dosing for amLODIPine Besy-Benazepril HCl is:
- Adults: Start with 1 capsule (5 mg/10 mg) once daily. The dosage may be adjusted based on the patient’s response, with a maximum dose of 10 mg/40 mg per day.
Elderly: Dose adjustments may be required based on the patient's response and tolerance.
Typical Dosing
FDA Approved Indications
amLODIPine Besy-Benazepril HCl is FDA-approved for the treatment of:
- Hypertension (high blood pressure), to lower blood pressure and reduce the risk of cardiovascular events such as heart attack and stroke.
There are no widely recognized off-label uses for this combination medication.
Who Shouldn't Take amLODIPine Besy-Benazepril HCl?
amLODIPine Besy-Benazepril HCl should not be used in patients with:
- A history of angioedema related to previous ACE inhibitor use
- Severe renal impairment or dialysis
- Known hypersensitivity to amlodipine, benazepril, or any of the components of the drug
- Pregnancy (due to the risk of fetal harm)
Advice From The Pharmacist
Patients taking amLODIPine Besy-Benazepril HCl should:
- Take the medication as prescribed, typically once daily, with or without food.
- Monitor blood pressure regularly and report any significant changes to their healthcare provider.
- Avoid potassium supplements or potassium-rich foods (e.g., bananas, oranges) unless directed by a healthcare provider, as this may increase the risk of hyperkalemia.
- Be aware of signs of angioedema (e.g., swelling of the face, lips, tongue) and seek immediate medical attention if these symptoms occur.
Side Effects of amLODIPine Besy-Benazepril HCl
Common Side Effects
Common side effects of amLODIPine Besy-Benazepril HCl include:
- Dizziness
- Headache
- Cough (due to the ACE inhibitor component)
- Edema (swelling)
Uncommon/Severe Side Effects
Serious side effects may include:
- Hyperkalemia (elevated potassium levels)
- Angioedema (swelling of the deeper layers of the skin)
- Severe hypotension (low blood pressure)
- Kidney dysfunction
Risks and Warnings of amLODIPine Besy-Benazepril HCl
Major risks and warnings associated with amLODIPine Besy-Benazepril HCl include:
- Angioedema: ACE inhibitors like benazepril can cause angioedema, a potentially life-threatening condition characterized by swelling of the face, throat, and extremities. Patients with a history of angioedema should not use this medication.
- Hyperkalemia: The use of ACE inhibitors can lead to elevated potassium levels, which can be dangerous, especially in patients with renal impairment or those taking potassium-sparing diuretics.
- Fetal Toxicity: ACE inhibitors are contraindicated during pregnancy due to the risk of fetal harm. Women of childbearing potential should use effective contraception while taking this medication.
Interactions with amLODIPine Besy-Benazepril HCl
Common Drug Interactions
amLODIPine Besy-Benazepril HCl may interact with:
- Potassium supplements and potassium-sparing diuretics: Increased risk of hyperkalemia.
- NSAIDs: May reduce the antihypertensive effect and increase the risk of kidney damage.
- Lithium: Increased risk of lithium toxicity when taken with ACE inhibitors.
Patients should inform their healthcare provider of all medications, supplements, and herbal products they are taking to avoid potential drug interactions.
Alternatives to amLODIPine Besy-Benazepril HCl
Alternative medications to amLODIPine Besy-Benazepril HCl include:
- Lisinopril-hydrochlorothiazide: A combination of an ACE inhibitor and a thiazide diuretic for hypertension.
- Valsartan-amlodipine (Exforge): A combination of an angiotensin II receptor blocker (ARB) and a calcium channel blocker for hypertension.
- Losartan-hydrochlorothiazide: A combination of an ARB and a thiazide diuretic used for blood pressure management.
