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aMILoride-hydroCHLOROthiazide
aMILoride-hydroCHLOROthiazide is a combination medication used primarily for the treatment of hypertension (high blood pressure) and to manage edema (fluid retention) associated with heart failure or other conditions. It combines two active ingredients: amiloride, a potassium-sparing diuretic, and hydrochlorothiazide, a thiazide diuretic. Amiloride helps the body retain potassium, while hydrochlorothiazide promotes the excretion of excess salt and water. Together, these medications work to lower blood pressure and reduce fluid buildup while minimizing the risk of hypokalemia (low potassium levels).
Drug Availability and Controlled Substance Status
aMILoride-hydroCHLOROthiazide is available in oral tablet form with various dosage combinations, including 5 mg/50 mg (amiloride/hydrochlorothiazide). It is not classified as a controlled substance, making it available with a prescription without the regulatory restrictions that apply to controlled drugs.
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Frequently Asked Questions
Can aMILoride-hydroCHLOROthiazide be taken with other blood pressure medications?
Yes, aMILoride-hydroCHLOROthiazide can be used in combination with other antihypertensive medications. However, careful monitoring of blood pressure and potassium levels is necessary, and dose adjustments may be required.
How should aMILoride-hydroCHLOROthiazide be stored?
Store aMILoride-hydroCHLOROthiazide at room temperature, away from moisture and light. Ensure that it is kept out of reach of children and pets.
Is aMILoride-hydroCHLOROthiazide safe during pregnancy?
There is limited data on the use of aMILoride-hydroCHLOROthiazide during pregnancy. It should only be used if the potential benefits outweigh the risks. Consult your healthcare provider for advice.
What should I do if I miss a dose of aMILoride-hydroCHLOROthiazide?
If you miss a dose, take it as soon as you remember, unless it is close to the time for your next dose. Do not double up on doses to make up for a missed one.
Comprehensive Drug Guide
How Does aMILoride-hydroCHLOROthiazide Work?
aMILoride-hydroCHLOROthiazide works through a dual mechanism of action. Amiloride blocks sodium channels in the distal tubules of the kidneys, preventing sodium reabsorption and promoting the excretion of sodium and water, while conserving potassium. Hydrochlorothiazide inhibits sodium reabsorption in the distal convoluted tubule, increasing the excretion of sodium, chloride, and water. Together, these actions help to reduce blood pressure and manage fluid retention while preventing potassium loss.
Common Dosages
aMILoride-hydroCHLOROthiazide is commonly available in the following dosage combinations:
- 5 mg/50 mg tablets (amiloride/hydrochlorothiazide)
Typical Dosing
The typical dosing for aMILoride-hydroCHLOROthiazide is:
- Adults: Start with 1 tablet (5 mg/50 mg) once daily. The dosage may be adjusted based on the patient’s response and clinical needs.
- Elderly: Dose adjustments may be required based on renal function.
Typical Dosing
FDA Approved Indications
aMILoride-hydroCHLOROthiazide is FDA-approved for the treatment of:
- Hypertension (high blood pressure)
- Edema (fluid retention) associated with heart failure, cirrhosis of the liver, or nephrotic syndrome
There are no widely recognized off-label uses for this combination medication.
Who Shouldn't Take aMILoride-hydroCHLOROthiazide?
aMILoride-hydroCHLOROthiazide should not be used in patients with:
- Anuria (inability to urinate)
- Hyperkalemia (elevated potassium levels)
- Severe renal impairment or end-stage renal disease (ESRD)
- Known hypersensitivity to amiloride, hydrochlorothiazide, or any of the components of the drug
- Addison’s disease (adrenal insufficiency)
Advice From The Pharmacist
Patients taking aMILoride-hydroCHLOROthiazide should:
- Take the medication as prescribed, usually once daily, with or without food.
- Monitor blood pressure regularly and report any significant changes to their healthcare provider.
- Avoid potassium supplements or potassium-rich foods (e.g., bananas, oranges) unless directed by a healthcare provider, as this may increase the risk of hyperkalemia.
- Be aware of symptoms of electrolyte imbalances (e.g., muscle cramps, weakness, irregular heartbeat) and report them to a healthcare provider.
Side Effects of aMILoride-hydroCHLOROthiazide
Common Side Effects
Common side effects of aMILoride-hydroCHLOROthiazide include:
- Dizziness
- Headache
- Nausea
- Fatigue
Uncommon/Severe Side Effects
Serious side effects may include:
- Hyperkalemia (elevated potassium levels)
- Hyponatremia (low sodium levels)
- Electrolyte imbalances
- Severe allergic reactions (e.g., rash, itching, swelling)
Risks and Warnings of aMILoride-hydroCHLOROthiazide
Major risks and warnings associated with aMILoride-hydroCHLOROthiazide include:
- Hyperkalemia: Amiloride may cause dangerously high potassium levels, particularly in patients with kidney disease or those taking other potassium-sparing medications. Regular monitoring of potassium levels is essential.
- Electrolyte Imbalances: Hydrochlorothiazide can cause imbalances in electrolytes, such as sodium, magnesium, and chloride. Regular blood tests may be necessary to monitor electrolyte levels.
Renal Function: Both amiloride and hydrochlorothiazide can affect kidney function. Patients with impaired renal function should be monitored closely, and dosage adjustments may be needed.
Interactions with aMILoride-hydroCHLOROthiazide
Common Drug Interactions
aMILoride-hydroCHLOROthiazide may interact with:
- ACE Inhibitors/ARBs: Increased risk of hyperkalemia when used together.
- NSAIDs: May reduce the effectiveness of the diuretic and antihypertensive effects of the medication.
- Lithium: Increased risk of lithium toxicity due to reduced renal clearance.
Patients should discuss all medications, supplements, and herbal products they are taking with their healthcare provider to avoid potential drug interactions.
Alternatives to aMILoride-hydroCHLOROthiazide
Alternative medications to aMILoride-hydroCHLOROthiazide include:
- Spironolactone-hydrochlorothiazide: Another combination of a potassium-sparing diuretic and a thiazide diuretic used for hypertension and edema.
- Triamterene-hydrochlorothiazide: A similar combination used to manage blood pressure and fluid retention.
- Furosemide: A loop diuretic often used for more severe fluid retention.
