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Aczone

Aczone (generic name: dapsone) is a topical gel used to treat acne vulgaris in patients 12 years and older. Dapsone is classified as a sulfonamide antibiotic but is applied topically to reduce inflammation and kill bacteria associated with acne breakouts. It helps clear existing pimples and prevents the formation of new ones by reducing bacterial growth and inflammation in the skin. Aczone is especially effective for treating inflammatory acne and is often prescribed when other treatments are not sufficient.



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Frequently Asked Questions

How long does it take for Aczone to work?
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It may take 8-12 weeks of consistent use to see significant improvements in acne. Continue using the gel as prescribed, even if results are not immediately visible.

Can I use Aczone with other acne treatments?
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Aczone can be used alongside certain other acne treatments, but avoid using it with benzoyl peroxide unless directed by your healthcare provider, as this can cause skin discoloration.

What should I do if I miss a dose of Aczone?
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If you forget to apply Aczone, apply it as soon as you remember. If it’s close to the time for your next application, skip the missed dose and resume your normal schedule. Do not double up on doses.

Is Aczone safe to use during pregnancy?
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Aczone is classified as a Pregnancy Category C medication, meaning there are no well-controlled studies in pregnant women. Consult your healthcare provider before using Aczone if you are pregnant or planning to become pregnant.

Can Aczone cause skin discoloration?
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When used with benzoyl peroxide, Aczone may cause temporary yellow or orange discoloration of the skin. Avoid using both products together unless directed by your healthcare provider.

Comprehensive Drug Guide

How Does Aczone Work?

Aczone works by combining its antibacterial and anti-inflammatory properties. The sulfone component (dapsone) reduces the number of acne-causing bacteria on the skin and reduces the inflammation associated with acne lesions. By controlling bacterial growth and calming the skin, it helps clear acne and prevent future breakouts.



Common Dosages

  • Topical gel: 5% and 7.5% strengths

Typical Dosing

  • For the 7.5% gel: Apply a pea-sized amount to the affected areas once daily.
  • For the 5% gel: Apply a thin layer to the affected areas twice daily, or as directed by your healthcare provider.
  • Always apply Aczone to clean, dry skin, and follow your healthcare provider’s instructions on how much and how often to use it.


Typical Dosing

FDA Approved Indications

  • The treatment of acne vulgaris in patients 12 years and older

Off-Label Uses

  • Off-label uses for Aczone may include treatment of other inflammatory skin conditions, though these uses should be discussed with a healthcare provider.



Who Shouldn't Take Aczone?

  • Known hypersensitivity to dapsone or any component of the formulation
  • Glucose-6-phosphate dehydrogenase (G6PD) deficiency, as it may increase the risk of hemolysis


Advice From The Pharmacist

  • Apply Aczone to clean, dry skin. Avoid getting the gel into your eyes, mouth, or mucous membranes.
  • You may notice some dryness, redness, or peeling of the skin during the first few weeks of treatment. These side effects are usually temporary.
  • If you have G6PD deficiency, discuss this with your healthcare provider, as Aczone may cause serious side effects in these patients.
  • Use sunscreen and avoid prolonged sun exposure, as Aczone may make your skin more sensitive to sunlight.
  • Do not use other acne medications containing benzoyl peroxide at the same time, as this can cause temporary skin discoloration.


Side Effects of Aczone

Common Side Effects

  • Skin dryness or peeling
  • Redness or irritation at the application site
  • Oiliness of the skin


Uncommon/Severe Side Effects

  • Hemolysis (especially in patients with G6PD deficiency)
  • Methemoglobinemia (a condition where oxygen delivery to tissues is reduced)


Risks and Warnings of Aczone

  • Hemolysis: Aczone can cause hemolytic anemia, especially in patients with G6PD deficiency. Healthcare providers should screen for G6PD deficiency before prescribing Aczone to ensure safety.
  • Methemoglobinemia: Rarely, Aczone can cause methemoglobinemia, which may reduce the oxygen supply to tissues and result in cyanosis (bluish discoloration of the skin).
  • Skin Sensitivity: Aczone can cause increased sensitivity to sunlight, so sunscreen and protective clothing are recommended when using this medication.


Interactions with Aczone

Common Drug Interactions

  • Benzoyl peroxide: Using benzoyl peroxide along with Aczone may cause the skin to temporarily turn yellow or orange. These products should not be used together unless advised by your healthcare provider.
  • Trimethoprim: Combining Aczone with this antibiotic may increase the risk of hemolytic anemia, particularly in those with G6PD deficiency.


Alternatives to Aczone

  • Benzoyl peroxide: A commonly used over-the-counter topical medication for acne that helps reduce bacteria and inflammation.
  • Retinoids such as Differin (adapalene) or Retin-A (tretinoin), which are topical treatments that promote skin cell turnover and reduce inflammation.
  • Clindamycin gel: A topical antibiotic used to treat mild to moderate acne by reducing the bacteria that cause acne.
  • Oral antibiotics such as doxycycline or minocycline, which may be prescribed for more severe cases of acne.