You're not logged in. Please log in to earn stock or Bitcoin rewards on your prescription purchase.
Activella
Activella (generic name: estradiol/norethindrone) is a hormone replacement therapy (HRT) medication used to treat symptoms of menopause, such as hot flashes, vaginal dryness, and osteoporosis prevention in women who are at risk of bone loss. It combines two hormones: estradiol, a form of estrogen, and norethindrone, a form of progestin. This combination helps reduce menopausal symptoms by replacing the estrogen that the body no longer produces naturally, while the progestin component helps protect against the overgrowth of the uterine lining, reducing the risk of endometrial cancer in women with an intact uterus.
Rx. Enter your prescription
How would you like to get your prescription? Select an option
Pharmacy pickup
Select from 35,000 pharmacies
Free two-day delivery
Coming soon!
Find a pharmacy near you. Enter your ZIP code
Are you a member? Sign up or log in.
Members have saved
$NaN
using our savings card for instant savings.
Don't pay full retail price and miss out on potential savings. Try it now—you have nothing to lose!
NaNM
worth of Satoshi has been rewarded to our members.
Everyone who signs up enjoys the benefits of earning FREE Bitcoin with every purchase.
How much Bitcoin can you earn with Activella ?
The potential for Bitcoin rewards to increase and appreciate in value is a possibility to consider, which may occur over time.
See the value of your savings today
Today's Value
1 Bitcoin = $NaN
Bitcoin (BTC)
...
USD
$NaN
Adjust Bitcoin's potential value to see how much it could be worth
Potential Value
1 Bitcoin =
Bitcoin (BTC)
...
USD
$NaN
Frequently Asked Questions
How long can I take Activella?
Hormone replacement therapy is generally recommended for the shortest possible duration to relieve symptoms. Long-term use may increase the risk of serious side effects, so it is important to have regular checkups with your healthcare provider.
Can Activella help with bone health?
Yes, Activella is approved to help prevent osteoporosis in postmenopausal women by maintaining bone density. However, it should only be used in women at high risk for osteoporosis who cannot use non-estrogen treatments.
Is it safe to take Activella if I have high blood pressure?
Women with controlled high blood pressure can take Activella, but blood pressure should be monitored regularly as hormone therapy can increase blood pressure in some patients.
What should I do if I miss a dose of Activella?
If you miss a dose, take it as soon as you remember unless it is close to your next scheduled dose. Do not take two doses at once to make up for a missed dose.
Can Activella cause weight gain?
Some women may experience weight changes, including weight gain, when using Activella, though this varies from person to person. Maintaining a healthy diet and exercise routine can help mitigate this effect.
Comprehensive Drug Guide
How Does Activella Work?
Activella works by replacing the estrogen that the body stops producing during menopause. Estrogen helps regulate many bodily functions, including maintaining bone density and managing the body’s temperature control mechanisms. The addition of norethindrone, a synthetic progestin, helps prevent the uterine lining from thickening, which can reduce the risk of endometrial hyperplasia and cancer in women who still have their uterus.
Common Dosages
- Tablets: 1 mg estradiol/0.5 mg norethindrone and 0.5 mg estradiol/0.1 mg norethindrone
Typical Dosing
- The usual dose for managing menopause symptoms is one tablet taken once daily. The dosage strength depends on the severity of symptoms and the patient’s response to treatment.
- For osteoporosis prevention, the lower dose of 0.5 mg estradiol/0.1 mg norethindrone is commonly prescribed.
Typical Dosing
FDA Approved Indications
- Treatment of moderate to severe vasomotor symptoms (such as hot flashes) due to menopause
- Prevention of postmenopausal osteoporosis in women at high risk
- Treatment of vulvar and vaginal atrophy associated with menopause
Who Shouldn't Take Activella?
- Undiagnosed abnormal vaginal bleeding
- Active or past history of breast cancer
- Known or suspected pregnancy
- Active blood clots or a history of thromboembolic disease
- Severe liver disease
Advice From The Pharmacist
- Take Activella at the same time each day, with or without food.
- Women using Activella should have regular medical checkups, including breast exams and mammograms, to monitor for signs of breast cancer or other hormone-related issues.
- Avoid smoking while taking Activella, as it increases the risk of blood clots, especially in women over 35.
- Use this medication for the shortest duration necessary to manage symptoms, as long-term use of hormone replacement therapy can increase the risk of breast cancer, heart disease, and stroke.
Side Effects of Activella
Common Side Effects
- Nausea
- Breast tenderness
- Headache
- Bloating
- Irregular vaginal bleeding
Uncommon/Severe Side Effects
- Increased risk of blood clots
- Stroke or heart attack
- Increased risk of breast or endometrial cancer
- Vision changes or sudden onset of migraines
Risks and Warnings of Activella
- Cardiovascular Risk: Activella can increase the risk of heart attack, stroke, and blood clots, particularly in older women or those with other risk factors such as smoking.
- Cancer Risk: Long-term use of estrogen, especially without progestin in women with a uterus, can increase the risk of uterine and breast cancer.
- Liver Function: Women with a history of liver disease should use Activella with caution, as estrogen and progestin can affect liver function.
Interactions with Activella
Common Drug Interactions
- Blood thinners (such as warfarin): Activella may decrease the effectiveness of blood thinners, increasing the risk of blood clots.
- Thyroid medications: Hormone replacement therapy can affect thyroid hormone levels, requiring adjustments in dosing.
- Certain antibiotics and antifungals can affect the metabolism of estradiol and norethindrone, altering their effectiveness.
Alternatives to Activella
- Prempro: Another combination hormone replacement therapy containing conjugated estrogens and medroxyprogesterone.
- Femhrt: A similar combination of low-dose estrogen and progestin.
- Estradiol alone: For women who have had a hysterectomy and do not need progestin.
- Non-hormonal alternatives: Medications like gabapentin or SSRIs (such as paroxetine) can help alleviate hot flashes without using hormones.
